Collected Dataset / CoLaus_PsyCoLaus_Metabolic_offspring_Psychiatric_evaluation_baseline

The population is composed of the offspring of the probands who are psychiatric patients with schizophrenia, bipolar disorder or major depressive disorder, are predominantly from European descent, and are Lausanne inhabitants aged 35 to 75 years.

Personality traits, temperament, attitudes, individual and family functioning, coping, and sleep patterns were assessed through a semi-structured diagnostic interview and a number of self-rating instruments. Mood disorders and other psychiatric illnesses, migraine (often associated with psychiatric disorders), temperament, and cognitive diseases are assessed through an interview. Diagnostic information was collected using the Diagnostic Interview for Genetic Studies. Additional data was collected based on interview techniques, including headache symptoms (Diagnostic Interview for Headache Syndromes (DIHS)) and life events (F. Amiel-Lebigre interview). Complementary information on personality, temperamental features, family functioning, social support, quality of life, job stress, and depression were obtained using a self-report battery including the following instruments: the State-Trait Anxiety Inventory (STAI), the Hypomania Checklist-32 first revised version (HCL-32-R1), the Multidimensional Scale of Perceived Social Support (MSPSS), the Manchester Short Assessment of Quality of Life (MANSA), NEO Five-Factor Inventory (NEO-FFI-R) - revised, the Maastricht Vital Exhaustion Questionnaire (MVEQ), the Siegrist Job Stress Questionnaire, the Maslach Burnout Inventory (MBI), a Depression screening test (CES-D), the Rosenberg Self-Esteem scale (RES) and the Perceived socioeconomic status. Cognitive function was assessed using the Do 80 (Epreuve de dénomination orale d’images) Cognitive Complaint Questionnaire, the Grober and Buschke episodic memory test CERAD praxis items, the Lexical and semantic fluency tasks, the Stroop color test, and the Clinical Dementia Rating (CDR) for severity staging. Additional phenotypes included an MRI for brain morphology and noise measurements during sleep.