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CoLaus|PsyCoLaus

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Start Year
2003
Supplementary Information
**Probands** Population-based cohort: Participants were randomly selected among the residents of the city of Lausanne according to the civil register between 2003 and 2006. The objectives were to study cardio-vascular risk factors and mental disorders as well as their associations in the general population. The baseline investigation also included genetic and environmental factors that could predispose to the development of cardiovascular diseases, such as ischemic myocardial diseases or stroke and psychiatric and cognitive disorders. Physical and psychiatric information on these probands is available from 6733 and 5144 participants, respectively.

Data on participants aged 65 years and older of this study have been used to build The Swiss Ageing Citizen Reference (SACR)

**Metabolic Probands** Metabolic cohort: Given the relative rareness of severe mental disorders in the general population, a cohort of psychiatric patients with schizophrenia, bipolar disorder or major depressive disorder originally enrolled in a study on metabolic complications under psychotropic drug treatment was recruited during the first follow-up of the population-based cohort. These patients were in the age range of the original cohort, fulfilled the same inclusion and exclusion criteria, had the same physical and psychiatric assessment as the original cohort and were followed-up in parallel. **Relatives of the Probands** The objectives of the recruitment of offspring younger than 18 years and spouses from 2007 to 2012 were to prospectively study the associations of parental disorders and environmental factors with the risk of onset of mental disorders during adolescence and young adulthood. The objectives of the recruitment of adult first-degree relatives and spouses from 2007 and 2012 were to determine the patterns of familial aggregation of mental disorders, to assess spouse similarity and assortative mating and to explore the mechanisms underlying the associations between mental disorders and cardiovascular risk factors through the investigation of patterns of aggregation and cross-aggregation of these disorders. The objectives of the recruitment of adult offspring from 2019 to 2023 were to assess mental disorders and obesity markers in young adulthood as well as their associations, to identify factors involved in these associations and to determine the genetic, familial and environmental determinants of the parent-offspring transmission of mental disorders and obesity markers. **Relatives of the Metabolic Probands (only psychiatric evaluations)** The objectives of the recruitment of offspring younger than 18 years and spouses from 2010 to 2014 were to prospectively study the associations of severe parental disorders and environmental factors with the risk of onset of mental disorders during adolescence and young adulthood.
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Investigators Contacts
  • Prof. Peter Vollenweider
    Lausanne University Hospital – CHUV and University of Lausanne
  • Prof. Martin Preisig
    Lausanne University Hospital – CHUV and University of Lausanne
  • Prof. Julien Vaucher
    Lausanne University Hospital – CHUV and University of Lausanne/University Teaching and Research Hospital and University of Fribourg
  • Prof. Armin von Gunten
    Centre hospitalier universitaire vaudois
  • Prof. Carole Clair
    Unisanté
  • Dr. Aurélie Lasserre
    Centre hospitalier universitaire vaudois
  • Prof. Peter Vollenweider
    Lausanne University Hospital – CHUV and University of Lausanne
  • Prof. Martin Preisig
    Lausanne University Hospital – CHUV and University of Lausanne
  • Prof. Julien Vaucher
    Lausanne University Hospital – CHUV and University of Lausanne/University Teaching and Research Hospital and University of Fribourg
  • Prof. Armin von Gunten
    Centre hospitalier universitaire vaudois
  • Prof. Carole Clair
    Unisanté
  • Dr. Aurélie Lasserre
    Centre hospitalier universitaire vaudois

Design

Study design
Cohort
Follow Up
**Probands** Recruitment went from 2003 to 2006. The physical baseline evaluation went from May 2003 to June 2006, and the psychiatric baseline evaluation went from January 2004 to May 2009. Participants were followed up for the physical evaluations between April 2009 and September 2012, May 2014 and April 2017, April 2018 and March 2021, and have been followed since January 2022 for the fourth follow-up. Participants were followed up for the psychiatric evaluations between January 2004 and May 2009, April 2010 and January 2014, November 2014 and July 2018, and April 2018 and September 2021, and have been followed up for the fourth wave since October 2021. Participants could participate in physical, psychiatric, or both evaluations. **Metabolic Probands** Recruitment for physical and psychiatric baseline evaluations went from 2010 to 2014. Participants were followed up for physical evaluations between May 2014 and April 2017, April 2018 and March 2021, and have been followed since January 2022. Participants were followed up for psychiatric evaluations between November 2014 and July 2018, April 2018 and September 2021, and have been followed since October 2021. **Relatives (of the probands)**

Offspring younger than 18 years and spouses of the probands of this cohort were recruited between 2007 and 2012 for the psychiatric baseline evaluation and were thereafter followed up every 3 years. Adult first-degree relatives were recruited between 2007 and 2012 for psychiatric and physical evaluations and were thereafter followed up every 3 years. Offspring aged 18 to 35 were recruited from 2019 to 2023 for physical and psychiatric evaluations and have been followed up every 3 years since 2019. **Relatives (of the metabolic probands)** Offspring and spouses of the probands were recruited between 2010 and 2014 for the baseline psychiatric evaluation and have since been followed up every 3 years. Starting in 2014, spouses and adult offspring have also undergone physical evaluations every 3 years.

Marker Paper

Firmann M, Mayor V, Vidal PM, et al. The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome. BMC Cardiovascular Disorder, 2008; Mar 17;8:6.

PUBMED 18366642

Recruitment

Recruitment Target
  • Individuals

Number of Participants

Number of Participants
10,312
Number of Participants with Biological Samples
7,769
Supplementary Information

Probands (population-based cohort): 6734 participants

Metabolic Probands : 90 participants

Relatives of the probands of the population-based cohort, recruited from 2007 to 2012 (psychiatric investigations only):

Parents: 219 participants

Siblings: 416 participants

Offspring (aged 18-years and older): 573 participants

Spouses: 388 participants

Minor offspring (younger than 18 years): 521 participants

Relatives of the probands of the population-based cohort recruited from 2019 to 2023 (physical and psychiatric investigations):

Offspring aged 18 to 35 years: 1350 participants 

Relatives of the probands of the metabolic cohort:

Offspring: 14 participants

Spouses: 7 participants

Access

Availability of data and biosamples

Possible Access to Data
Possible Access to Biosamples
Other
  • Possible Access to MRI data, acquired using a harmonized protocol in (SACR)
  • Possible Access to EPIC v2.0 DNA methylation data, measured from prospective blood samples for the study participants with complete MRI data in (SACR)
  • Possible Access to geocoded residential address
Yes
No
Not applicable
Don't know

Timeline

Populations

Selection Criteria
Minimum age
35
Maximum age
75
Newborns
Twins
Countries
  • Switzerland
Territory
City of Lausanne
Ethnic Origin
Health Status
Other Criteria
Supplementary Information about selection criteria

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample
Supplementary Information
A random sampling procedure based on a complete list of the inhabitants of Lausanne aged 35 to 75 years, according to the civil register of the city, was used. Subjects who agreed to participate were contacted by phone within 14 days. Subjects who did not answer the first invitation were sent a second invitation letter. If no answer was obtained, participants were contacted by phone. After completion of the physical evaluation, participants were contacted by the psychiatric team by letters and phone calls to elicit consent for the psychiatric part.

Number of Participants

Number of Participants
6,734
Number of Participants with Biological Samples
6,733
Supplementary Information about selection criteria

Total cohort at Baseline: 6734 participants

Physical evaluation Baseline: 6733 participants

Psychiatric evaluation Baseline: 3720 participants

Physical evaluation Follow-up 1: 5064 participants

Psychiatric evaluation Follow-up 1: 4007 participants

Physical evaluation Follow-up 2: 4881 participants

Psychiatric evaluation Follow-up 2: 3667 participants

Physical evaluation Follow-up 3: 3972 participants

Psychiatric evaluation Follow-up 3: 3018 participants

The cohort is composed of 52.6% of women and 91% European descent. The cohort did not significantly differ from the population of Lausanne with respect to the sex distribution, but the two youngest and the two oldest age bands were underrepresented.
Data Collection Events
# Name Description Start End
0 CoLaus|PsyCoLaus - Probands - Physical evaluation baseline Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake, sleep, diet, and physical activity), personal history of diseases (diabetes, stroke, myocardial ... 2003-05 2006-06
1 CoLaus|PsyCoLaus - Probands - Psychiatric evaluation baseline Information collected is an assessment of personality, temperament, family functioning, social support, and quality of life. Diagnostic information was collected using the Diagnostic Interview ... 2004-01 2009-05
2 CoLaus|PsyCoLaus - Probands - Physical evaluation follow-up 1 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake), personal history of diseases (diabetes, stroke, myocardial infarction, and coronary procedures ... 2009-04 2012-09
3 CoLaus|PsyCoLaus - Probands - Psychiatric evaluation follow-up 1 A semi-structured diagnostic interview and a number of self-rating instruments evaluating personality traits, attitudes, and functioning were assessed. Diagnostic information was collected using ... 2010-04 2014-01
4 CoLaus|PsyCoLaus - Probands - Physical evaluation follow-up 2 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol), health service utilization, personal history of diseases (diabetes, stroke, myocardial infarction, ... 2014-05 2017-04
5 CoLaus|PsyCoLaus - Probands - Psychiatric evaluation follow-up 2 Personality traits, attitudes, and functioning were assessed through a semi-structured diagnostic interview and a number of self-rating instruments. Diagnostic information was collected using the ... 2014-11 2018-07
6 CoLaus|PsyCoLaus - Probands - Physical evaluation follow-up 3 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake), health service utilization, personal history of diseases (diabetes, stroke, myocardial ... 2018-04 2021-03
7 CoLaus|PsyCoLaus - Probands - Psychiatric evaluation follow-up 3 Personality traits, attitudes, and functioning were assessed through a semi-structured diagnostic interview and a number of self-rating instruments. Diagnostic information was collected using the ... 2018-04 2021-09
8 CoLaus|PsyCoLaus - Probands - Psychiatric evaluation follow-up 4 Personality traits, temperament, attitudes, individual and family functioning, coping, and sleep patterns were assessed through a semi-structured diagnostic interview and a number of self-rating ... 2021-10
9 CoLaus|PsyCoLaus - Probands - Physical evaluation follow-up 4 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake), health service utilization, personal history of diseases (diabetes, stroke, myocardial ... 2022-10
Selection Criteria
Minimum age
18
Newborns
Twins
Territory
Ethnic Origin
Health Status
Other Criteria

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample
Supplementary Information
During the psychiatric evaluations between 2007 and 2012, all participants (probands) from the original cohort (probands) were systematically asked, whether they would allow the study to contact their first-degree relatives. If they agreed, written consent was requested for each relative in order to give the study permission to contact this person and to complete a brief self-report pedigree including the addresses and phone numbers of their relatives. These relatives were then invited by letter to participate. Those who agreed were contacted by a psychologist by phone, who provided further information on the study and sent them the detailed information letter and consent forms.

Number of Participants

Number of Participants
635
Number of Participants with Biological Samples
Supplementary Information about selection criteria

Parents: 219 participants

Siblings: 416 participants

Data Collection Events
# Name Description Start End
0 CoLaus|PsyCoLaus - First-degree Relatives - Psychiatric evaluation Information collected on personality, temperament, family functioning, social support, and quality of life was assessed using self-rating questionnaires. Diagnostic information was obtained ... 2007 2012
1 CoLaus|PsyCoLaus - First-degree Relatives - Physical evaluation baseline Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake, sleep, diet, and physical activity), personal history of diseases (diabetes, stroke, myocardial ... 2007 2012
2 CoLaus|PsyCoLaus - First-degree Relatives - Psychiatric evaluation follow-up 1 Diagnostic information was collected using the Diagnostic Interview for Genetic Studies (DIGS). Additional data was collected based on interview techniques, including headache symptoms ... 2010 2015
3 CoLaus|PsyCoLaus - First-degree Relatives - Physical evaluation follow-up 1 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake), personal history of diseases (diabetes, stroke, myocardial infarction, and coronary procedures ... 2010 2015
4 CoLaus|PsyCoLaus - First-degree Relatives - Psychiatric evaluation follow-up 2 Personality traits, attitudes, and functioning were assessed through a semi-structured diagnostic interview and a number of self-rating instruments. Diagnostic information was collected using the ... 2013 2017
5 CoLaus|PsyCoLaus - First-degree Relatives - Physical evaluation follow-up 2 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol), health service utilization, personal history of diseases (diabetes, stroke, myocardial infarction, ... 2013 2017
6 CoLaus|PsyCoLaus - First-degree Relatives - Psychiatric evaluation follow-up 3 Personality traits, attitudes, and functioning were assessed through a semi-structured diagnostic interview and a number of self-rating instruments. Diagnostic information was collected using the ... 2016 2020
7 CoLaus|PsyCoLaus - First-degree Relatives - Physical evaluation follow-up 3 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake), health service utilization, personal history of diseases (diabetes, stroke, myocardial ... 2016 2020
Selection Criteria
Minimum age
18
Newborns
Twins
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample
Supplementary Information
During the psychiatric evaluations between 2007 and 2012 all participants (probands) of the original cohort were systematically asked whether they would allow the study to contact their first-degree relatives. If they agreed, written consent was also requested to contact their spouse. The spouse was then invited by letter to participate. Those who agreed were contacted by a psychologist by phone, who provided further information on the study and sent them the detailed information letter and consent forms.

Number of Participants

Number of Participants
388
Number of Participants with Biological Samples
Data Collection Events
# Name Description Start End
0 CoLaus|PsyCoLaus - Spouses - Psychiatric evaluation baseline Information collected is an assessment of personality, temperament, family functioning, social support, and quality of life through self-rating questionnaires. Diagnostic information was ... 2007 2012
1 CoLaus|PsyCoLaus - Spouses - Physical evaluation baseline Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake, sleep, diet, and physical activity), personal history of diseases (diabetes, stroke, myocardial ... 2007 2012
2 CoLaus|PsyCoLaus - Spouses - Psychiatric evaluation follow-up 1 A semi-structured diagnostic interview and a number of self-rating instruments evaluating personality traits, attitudes, and functioning were assessed. Diagnostic information was collected using ... 2010 2015
3 CoLaus|PsyCoLaus - Spouses - Physical evaluation follow-up 1 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake), personal history of diseases (diabetes, stroke, myocardial infarction, and coronary procedures ... 2010 2015
4 CoLaus|PsyCoLaus - Spouses - Psychiatric evaluation follow-up 2 Personality traits, attitudes, and functioning were assessed through a semi-structured diagnostic interview and a number of self-rating instruments. Diagnostic information was collected using the ... 2013 2017
5 CoLaus|PsyCoLaus - Spouses - Physical evaluation follow-up 2 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol), health service utilization, personal history of diseases (diabetes, stroke, myocardial infarction, ... 2013 2017
6 CoLaus|PsyCoLaus - Spouses - Psychiatric evaluation follow-up 3 Personality traits, attitudes, and functioning were assessed through a semi-structured diagnostic interview and a number of self-rating instruments. Diagnostic information was collected using the ... 2016 2020
7 CoLaus|PsyCoLaus - Spouses - Physical evaluation follow-up 3 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake), health service utilization, personal history of diseases (diabetes, stroke, myocardial ... 2016 2020
Selection Criteria
Minimum age
4
Maximum age
17
Newborns
Twins
Ethnic Origin
Health Status
Other Criteria

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample
Supplementary Information
During the psychiatric evaluations between 2007 and 2012 all participants (probands) of the original cohort were systematically asked whether they would allow the study to contact their minor offspring aged 4 to 17 years. If they agreed, written consent was requested for each minor child to give the study permission to contact this child. These children were then invited by letter to participate. Those who agreed were contacted by a psychologist by phone, who provided further information on the study and sent them the detailed information letter and consent forms. Consent was requested from both parents and children.

Number of Participants

Number of Participants
521
Number of Participants with Biological Samples
Data Collection Events
# Name Description Start End
0 CoLaus|PsyCoLaus - Minor Offspring - Psychiatric evaluation baseline Information collected is an assessment of personality, temperament, family functioning, social support, and quality of life through self-rating questionnaires. Diagnostic information was ... 2007 2012
1 CoLaus|PsyCoLaus - Minor Offspring - Psychiatric evaluation follow-up 1 Personality traits, attitudes, and functioning were assessed through a semi-structured diagnostic interview and a number of self-rating instruments. Diagnostic information was collected using the ... 2010 2015
2 CoLaus|PsyCoLaus - Minor Offspring - Psychiatric evaluation follow-up 2 Personality traits, attitudes, and functioning were assessed through a semi-structured diagnostic interview and a number of self-rating instruments. Diagnostic information was collected using the ... 2013 2018
3 CoLaus|PsyCoLaus - Minor Offspring - Psychiatric evaluation follow-up 3 Personality traits, attitudes, and functioning were assessed through a semi-structured diagnostic interview and a number of self-rating instruments. Diagnostic information was collected using the ... 2016 2021
Selection Criteria
Minimum age
18
Maximum age
35
Newborns
Twins
Countries
  • Switzerland
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample
Supplementary Information
During the third and the fourth physical and psychiatric follow-up evaluation, all participants (probands) of the original cohort were systematically asked whether they would allow the study to contact their offspring in the age range between 18 and 35 years. If they agreed, written consent was requested for each offspring to give the study permission to contact this person. These offspring were then invited by letter to participate. Those who agreed were contacted by a psychologist or study nurse by phone, who provided further information on the study and sent them the detailed information letter and consent forms. Those who completed first the psychiatric evaluation, were contacted by the somatic team in a second step and vice versa.

Number of Participants

Number of Participants
1,923
Number of Participants with Biological Samples
998
Data Collection Events
# Name Description Start End
0 CoLaus|PsyCoLaus - Adult Offsping - Psychiatric evaluation baseline Personality traits, attitudes, and functioning were assessed through a semi-structured diagnostic interview and a number of self-rating instruments. Diagnostic information was collected using the ... 2019 2023
1 CoLaus|PsyCoLaus - Adult Offsping - Physical evaluation baseline Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake), health service utilization, personal history of diseases (diabetes, stroke, myocardial ... 2019 2023
2 CoLaus|PsyCoLaus - Adult Offsping - Psychiatric evaluation follow-up 1 Personality traits, attitudes, and functioning were assessed through a semi-structured diagnostic interview and a number of self-rating instruments. Diagnostic information was collected using the ... 2022 2026
3 CoLaus|PsyCoLaus - Adult Offsping - Physical evaluation follow-up 1 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake), health service utilization, personal history of diseases (diabetes, stroke, myocardial ... 2022 2026
4 CoLaus|PsyCoLaus - Adult Offsping - Psychiatric evaluation follow-up 2 Personality traits, attitudes, and functioning were assessed through a semi-structured diagnostic interview and a number of self-rating instruments. Diagnostic information was collected using the ... 2025 2029
5 CoLaus|PsyCoLaus - Adult Offsping - Physical evaluation follow-up 2 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake), health service utilization, personal history of diseases (diabetes, stroke, myocardial ... 2025 2029
6 CoLaus|PsyCoLaus - Adult Offsping - Psychiatric evaluation follow-up 3 Personality traits, attitudes, and functioning were assessed through a semi-structured diagnostic interview and a number of self-rating instruments. Diagnostic information was collected using the ... 2028 2032
7 CoLaus|PsyCoLaus - Adult Offsping - Physical evaluation follow-up 3 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake), health service utilization, personal history of diseases (diabetes, stroke, myocardial ... 2028 2032
Selection Criteria
Minimum age
35
Maximum age
75
Newborns
Twins
Countries
  • Switzerland
Territory
City of Lausanne
Ethnic Origin
Health Status
  • Psychiatric patients with schizophrenia, bipolar disorder or major depressive disorder.
Other Criteria

Recruitment

Sources of recruitment
  • Participants from existing studies
Supplementary Information
In parallel to the first follow-up of the original cohort (probands), psychiatric patients with schizophrenia, bipolar disorder or major depressive disorder, enrolled in a study on metabolic complications under psychotropic drug treatment and in the age range of the original cohort (probands), were systematically contacted by letter and phone to ask whether they would be willing to participate. After completion of the psychiatric evaluation, participants were contacted by the somatic team by letters and phone calls to elicit consent also for the physical part.
Participants from Existing Studies
  • From a study on metabolic complications under psychotropic drug treatment

Number of Participants

Number of Participants
90
Number of Participants with Biological Samples
38
Supplementary Information about selection criteria

Parents of the original cohort participants: 1 participant

Siblings of the original cohort participants: 1 participant

Data Collection Events
# Name Description Start End
0 CoLaus|PsyCoLaus - Metabolic Probands - Psychiatric evaluation baseline A semi-structured diagnostic interview and a number of self-rating instruments evaluating personality traits, attitudes, and functioning were assessed. Diagnostic information was collected using ... 2010-01 2014-01
1 CoLaus|PsyCoLaus - Metabolic Probands - Physical evaluation baseline Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake, sleep, diet, and physical activity), personal history of diseases (diabetes, stroke, myocardial ... 2010-01 2014-01
2 CoLaus|PsyCoLaus - Metabolic Probands - Physical evaluation follow-up 1 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol), health service utilization, personal history of diseases (diabetes, stroke, myocardial infarction, ... 2014-05 2017-04
3 CoLaus|PsyCoLaus - Metabolic Probands - Psychiatric evaluation follow-up 1 Personality traits, attitudes, and functioning were assessed through a semi-structured diagnostic interview and a number of self-rating instruments. Diagnostic information was collected using the ... 2014-11 2018-07
4 CoLaus|PsyCoLaus - Metabolic Probands - Physical evaluation follow-up 2 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake), health service utilization, personal history of diseases (diabetes, stroke, myocardial ... 2018-04 2021-03
5 CoLaus|PsyCoLaus - Metabolic Probands - Psychiatric evaluation follow-up 2 Personality traits, attitudes, and functioning were assessed through a semi-structured diagnostic interview and a number of self-rating instruments. Diagnostic information was collected using the ... 2018-04 2021-09
6 CoLaus|PsyCoLaus - Metabolic Probands - Psychiatric evaluation follow-up 3

This information is through diagnostic interviews and self-rating questionnaires

Personality traits, temperament, attitudes, individual and family functioning, coping, and ...		 2021-10
7 CoLaus|PsyCoLaus - Metabolic Probands - Physical evaluation follow-up 3 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake), health service utilization, personal history of diseases (diabetes, stroke, myocardial ... 2022-10
Selection Criteria
Minimum age
35
Maximum age
75
Newborns
Twins
Countries
  • Switzerland
Territory
City of Lausanne
Ethnic Origin
Health Status
  • Psychiatric patients with schizophrenia, bipolar disorder or major depressive disorder.

Recruitment

Sources of recruitment
  • Participants from existing studies
Supplementary Information
During the psychiatric baseline evaluation of the participants (probands) of the metabolic cohort 2010-2014, participants were systematically asked whether they would allow the study to contact their spouses. The spouse was then invited by letter to participate. Those who agreed were contacted by a psychologist by phone, who provided further information on the study and sent them the detailed information letter and consent forms. In parallel to the first follow-up of the original cohort (probands), psychiatric patients with schizophrenia, bipolar disorder or major depressive disorder, enrolled in a study on metabolic complications under psychotropic drug treatment and in the age range of the original cohort (probands), were systematically contacted by letter and phone to ask whether they would be willing to participate. After completion of the psychiatric evaluation, participants were contacted by the somatic team by letters and phone calls to elicit consent also for the physical part.
Participants from Existing Studies
  • From a study on metabolic complications under psychotropic drug treatment

Number of Participants

Number of Participants
7
Number of Participants with Biological Samples
Data Collection Events
# Name Description Start End
0 CoLaus|PsyCoLaus - Metabolic Spouses - Psychiatric evaluation baseline A semi-structured diagnostic interview and a number of self-rating instruments evaluating personality traits, attitudes, and functioning were assessed. Diagnostic information was collected using ... 2010 2014
1 CoLaus|PsyCoLaus - Metabolic Spouses - Psychiatric evaluation follow-up 1 Personality traits, temperament, attitudes, individual and family functioning, coping, and sleep patterns were assessed through a semi-structured diagnostic interview and a number of self-rating ... 2013 2017
2 CoLaus|PsyCoLaus - Metabolic Spouses - Physical evaluation baseline Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake), health service utilization, personal history of diseases (diabetes, stroke, myocardial ... 2014 2017
3 CoLaus|PsyCoLaus - Metabolic Spouses - Psychiatric evaluation follow-up 2 Personality traits, temperament, attitudes, individual and family functioning, coping, and sleep patterns were assessed through a semi-structured diagnostic interview and a number of self-rating ... 2016 2020
4 CoLaus|PsyCoLaus - Metabolic Spouses - Physical evaluation follow-up 1 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake), health service utilization, personal history of diseases (diabetes, stroke, myocardial ... 2017 2020
5 CoLaus|PsyCoLaus - Metabolic Spouses - Psychiatric evaluation follow-up 3 Personality traits, temperament, attitudes, individual and family functioning, coping, and sleep patterns were assessed through a semi-structured diagnostic interview and a number of self-rating ... 2019 2023
6 CoLaus|PsyCoLaus - Metabolic Spouses - Physical evaluation follow-up 2 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake), health service utilization, personal history of diseases (diabetes, stroke, myocardial ... 2020 2023
7 CoLaus|PsyCoLaus - Metabolic Spouses - Physical evaluation follow up 3 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake), health service utilization, personal history of diseases (diabetes, stroke, myocardial ... 2023
Selection Criteria
Minimum age
35
Maximum age
75
Newborns
Twins
Territory
City of Lausanne
Ethnic Origin
Health Status
  • Psychiatric patients with schizophrenia, bipolar disorder or major depressive disorder.

Recruitment

Sources of recruitment
  • Participants from existing studies
Supplementary Information
During the psychiatric baseline evaluation of the participants (probands) of the metabolic cohort 2010-2014, they were systematically asked whether they would allow the study to contact their offspring. Those who agreed were contacted by a psychologist by phone, who provided further information on the study and sent them the detailed information letter and consent forms. In parallel to the first follow-up of the original cohort (probands), psychiatric patients with schizophrenia, bipolar disorder or major depressive disorder, enrolled in a study on metabolic complications under psychotropic drug treatment and in the age range of the original cohort (probands), were systematically contacted by letter and phone to ask whether they would be willing to participate. After completion of the psychiatric evaluation, participants were contacted by the somatic team by letters and phone calls to elicit consent also for the physical part.
Participants from Existing Studies
  • From a study on metabolic complications under psychotropic drug treatment

Number of Participants

Number of Participants
7
Number of Participants with Biological Samples
Data Collection Events
# Name Description Start End
0 CoLaus|PsyCoLaus - Metabolic Offspring - Psychiatric evaluation baseline A semi-structured diagnostic interview and a number of self-rating instruments evaluating personality traits, attitudes, and functioning were assessed. Diagnostic information was collected using ... 2010 2014
1 CoLaus|PsyCoLaus - Metabolic Offspring - Psychiatric evaluation follow-up 1 Personality traits, temperament, attitudes, individual and family functioning, coping, and sleep patterns were assessed through a semi-structured diagnostic interview and a number of self-rating ... 2013 2017
2 CoLaus|PsyCoLaus - Metabolic Offspring - Physical evaluation baseline Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake), health service utilization, personal history of diseases (diabetes, stroke, myocardial ... 2014 2017
3 CoLaus|PsyCoLaus - Metabolic Offspring - Psychiatric evaluation follow-up 2 Personality traits, temperament, attitudes, individual and family functioning, coping, and sleep patterns were assessed through a semi-structured diagnostic interview and a number of self-rating ... 2016 2020
4 CoLaus|PsyCoLaus - Metabolic Offspring - Physical evaluation follow-up 1 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake), health service utilization, personal history of diseases (diabetes, stroke, myocardial ... 2017 2020
5 CoLaus|PsyCoLaus - Metabolic Offspring - Psychiatric evaluation follow-up 3 Personality traits, temperament, attitudes, individual and family functioning, coping, and sleep patterns were assessed through a semi-structured diagnostic interview and a number of self-rating ... 2019 2023
6 CoLaus|PsyCoLaus - Metabolic Offspring - Physical evaluation follow-up 2 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake), health service utilization, personal history of diseases (diabetes, stroke, myocardial ... 2020 2023
7 CoLaus|PsyCoLaus - Metabolic Offspring - Physical evaluation follow-up 3 Information on demographic data, socioeconomic status, lifestyle behaviors (smoking, alcohol intake), health service utilization, personal history of diseases (diabetes, stroke, myocardial ... 2023
Selection Criteria
Minimum age
4
Maximum age
17
Newborns
Twins
Countries
  • Switzerland
Territory
City of Lausanne
Ethnic Origin
Health Status
  • Psychiatric patients with schizophrenia, bipolar disorder or major depressive disorder.

Recruitment

Sources of recruitment
  • Participants from existing studies
Supplementary Information
During the psychiatric baseline evaluation of the participants (probands) of the metabolic cohort 2010-2014, they were systematically asked, whether they would allow the study to contact their minor offspring aged 4 to 17 years. If they agreed, written consent was requested for each minor child to give the study permission to contact this child. These children were then invited by letter to participate. Those who agreed were contacted by a psychologist by phone, who provided further information on the study and sent them the detailed information letter and consent forms. Consent was requested from both parents and children.
Participants from Existing Studies
  • From a study on metabolic complications under psychotropic drug treatment

Number of Participants

Number of Participants
7
Number of Participants with Biological Samples
Data Collection Events
# Name Description Start End
0 CoLaus|PsyCoLaus - Metabolic Minor Offspring - Psychiatric evaluation baseline Information collected is an assessment of personality, temperament, family functioning, social support, and quality of life through self-rating questionnaires. Diagnostic information was ... 2010 2014
1 CoLaus|PsyCoLaus - Metabolic Minor Offspring - Psychiatric evaluation follow-up 1 Personality traits, attitudes, and functioning were assessed through a semi-structured diagnostic interview and a number of self-rating instruments. Diagnostic information was collected using the ... 2013 2017
2 CoLaus|PsyCoLaus - Metabolic Minor Offspring - Psychiatric evaluation follow-up 2 Personality traits, attitudes, and functioning were assessed through a semi-structured diagnostic interview and a number of self-rating instruments. Diagnostic information was collected using the ... 2016 2020
3 CoLaus|PsyCoLaus - Metabolic Minor Offspring - Psychiatric evaluation follow-up 3 Personality traits, attitudes, and functioning were assessed through a semi-structured diagnostic interview and a number of self-rating instruments. Diagnostic information was collected using the ... 2019 2023

Classifications

Socio-demographic and economic characteristics
Lifestyle and behaviours
Birth, pregnancy and reproductive health history
Perception of health, quality of life, development and functional limitations
Diseases
Symptoms and signs
Medication and supplements
Non-pharmacological interventions
Health and community care services utilization
Death
Physical measures and assessments
Laboratory measures
Cognition, personality and psychological measures and assessments
Life events, life plans, beliefs and values
Preschool, school and work life
Social environment and relationships
Physical environment
Administrative information
Cognitive functioning
Personality
Psychological distress and emotions
Other psychological measures and assessments
Perception of health
Quality of life
Life course development
Functional limitations
Other perception of health, quality of life and functional limitation-related information
Tobacco
Alcohol
Drugs
Nutrition
Breastfeeding
Physical activity
Sleep
Sexual behaviours and orientation
Technological devices
Misbehaviour and criminality
Other and unspecified lifestyle information
Social network
Social participation
Social support
Parenting and familial environment
Other social environment characteristics

Socio-demographic and economic characteristics

Age/birthdate
Sex/gender
Marital/partner status
Family and household structure
Education
Residence
Birthplace
Citizenship and immigrant status
Ethnicity, race and religion
Labour force and retirement
Income, possessions, and benefits
Other socio-demographic and economic characteristics

Lifestyle and behaviours

Tobacco
Alcohol
Nutrition
Physical activity
Sleep
Technological devices

Birth, pregnancy and reproductive health history

Puberty, menstruation, menopause and andropause
Contraception
Pregnancy, delivery and birth

Perception of health, quality of life, development and functional limitations

Perception of health
Quality of life
Functional limitations
Use of assistive devices

Diseases

Certain infectious and parasitic diseases (A00-B99)
Neoplasms (C00-D48)
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
Endocrine, nutritional and metabolic diseases (E00-E90)
Mental and behavioural disorders (F00-F99)
Diseases of the nervous system (G00-G99)
Diseases of the circulatory system (I00-I99)
Diseases of the respiratory system (J00-J99)
Diseases of the digestive system (K00-K93)
Diseases of the skin and subcutaneous tissue (L00-L99)
Diseases of the musculoskeletal system and connective tissue (M00-M99)
Diseases of the genitourinary system (N00-N99)
Pregnancy, childbirth and the puerperium (O00-O9A)
Congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
Injury, poisoning and certain other consequences of external causes (S00-T98)
External causes of morbidity and mortality (V01-Y98)
Diseases without precise specification or falling into multiple categories

Symptoms and signs

Symptoms and signs involving the digestive system and abdomen (R10-R19)
General symptoms and signs (R50-R69)

Medication and supplements

Medication and supplement intake

Non-pharmacological interventions

Surgical interventions
Laboratory diagnosis interventions
Other and unspecified non-pharmacological interventions

Health and community care services utilization

Visits to health professionals
Hospitalizations
Community and social care

Death

Vital status
Cause of death

Physical measures and assessments

Physical characteristics
Anthropometry
Circulation and respiration
Muscles, skeleton and mobility
Brain and nerves
Skin and subcutaneous tissue
Other physical measures and assessments

Laboratory measures

Hematology
Biochemistry
Immunology
Genomics

Cognition, personality and psychological measures and assessments

Cognitive functioning
Personality
Psychological distress and emotions

Life events, life plans, beliefs and values

Life events

Preschool, school and work life

Work life

Social environment and relationships

Social support

Administrative information

Identifiers
Date and time-related information
Questionnaire and interview-related information
Physical and cognitive measure and biosample-related information
Data and sample collection center-related information
Other administrative information

Cognitive functioning

Clinical Dementia Rating Scale
CERAD Constructional Praxis Recall
Oral Denomination 80 Test
Free and Cued Selective Reminding Test
Letter Fluency Test
Mini-Mental State Examination
Subjective Cognitive Complaints
Stroop Color and Word Test
Verbal Fluency

Personality

Bortner Scale
Dimensions of Temperament Survey
Eysenck Personality Questionnaire
NEO Personality Inventory
Rosenberg Self-Esteem Scale
Retrospective Self Report Childhood Inhibition
Sensitivity to Punishment and Sensitivity to Reward Questionnaire
Type-D Scale

Psychological distress and emotions

Center for Epidemiological Studies Depression Scale
Hypomania Checklist
Maslach Burnout Inventory - General Survey
Maastricht Vital Exhaustion Questionnaire
Perceived Stress Scale
Symptom Checklist 90
Spielberger State-Trait Anxiety Inventory

Quality of life

Chalder Fatigue Scale
Fatigue Severity Scale
Manchester Short Assessment of Quality of Life

Nutrition

Food Frequency Questionnaire (different forms)

Physical activity

Physical Activity Frequency Questionnaire

Sleep

Berlin Questionnaire
Epworth Sleepiness Scale
Insomnia Severity Index
Morningness-Eveningness Questionnaire
Medical Outcomes Study Sleep Scale
Pittsburgh Sleep Quality Index

Social support

Dyadic Adjustment Scale
Family Adaptability and Cohesion Evaluation Scale
Family Attitude Scale
Multidimensional Scale of Perceived Social Support