Swiss Transplant Cohort Study
Networks
-
Datasets
-
Variables
-
The main objectives of this study are to:
* Record all solid organ transplants (SOTs) within one unique database system in order to have a complete assessment of all patient-, transplant-, and center-specific activities in Switzerland.
* Prospectively collect high quality longitudinal clinical and laboratory data of transplant recipients at the Swiss national level, to evaluate the quality, effectiveness and efficiency of SOT in order to support patients, health care professionals and policy makers with informed decision-making.
* Implement a bio-bank sampling scheme to integrate biological and clinical information.
* Reflect the complexity of the post-transplant patient care in an appropriate data model and integrate this complexity into research hypothesis and methodology.
* Collect selected psychosocial and behavioral data at time of listing and during follow-up.
* Systematically capture relevant infectious diseases episodes.
* Record and periodically update specific risk profiles to reflect changes in disease- and treatment status.
* Assess determinants of poor short- or long-term outcome and allow studying alternative pathways that contribute to the understanding of patient – and allograft survival.
- Start Year
- 2008
- Supplementary Information
-
STCS is an internationally recognized research platform. STCS research data and samples are open to researchers. More than 200 projects are using STCS data.
van Delden C, Stampf S, Hirsch HH, e al. Burden and Timeline of Infectious Diseases in the First Year After Solid Organ Transplantation in the Swiss Transplant Cohort Study. Clinical Infectious Disease. 2020;71(7):e159-e169. PMID: 31915816
Visit STCS
| Investigators | Contacts |
|---|---|
|
|
Design
- Study design
- Cohort
- Follow Up
- Follow-up assessments took place at 6 and 12 months and yearly thereafter. In the case of a second or re-transplantation, three extra assessments were performed of the new case at baseline, 6, and 12 months and the patient data in regard to the new case was updated.
Marker Paper
Stampf S, Mueller NJ, van Delden C, et al. Cohort profile: The Swiss Transplant Cohort Study (STCS): A nationwide longitudinal cohort study of all solid organ recipients in Switzerland. BMJ Open 2021;11:e051176.
PUBMED 34911712
Recruitment
- Recruitment Target
-
- Individuals
Number of Participants
- Number of Participants
- 6,311
- Number of Participants with Biological Samples
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Timeline
STCS population
The population is composed of solid organ transplant recipients (including first, second of re-transplant cases) transplanted in Switzerland.
Selection Criteria
- Newborns
- Twins
- Countries
-
- Switzerland
- Ethnic Origin
-
- Health Status
-
- Patients with grafts (solid organ) implanted since May 2008.
- Supplementary Information about selection criteria
- Participants were recruited at all six Swiss transplant centers involved in the study.
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Tissue transplantations are not considered.
Number of Participants
- Number of Participants
- 6,311
- Number of Participants with Biological Samples
- Supplementary Information about selection criteria
-
Renal transplant recipients: 3598 participants
Liver transplant recipients: 1386 participants
Lung transplant recipients: 564 participants
Heart transplant recipients: 469 participants
Kidney-pancreas transplant recipients: 133 participants
Kidney-liver transplant recipients: 55 participants
Islets transplant recipients: 40 participants
Kidney-islets transplant recipients: 23 participants
Kidney-heart transplant recipients: 14 participants
Pancreas transplant recipients: 13 participants
Other rare transplant scenarios: 16 participants
Pediatric transplant recipients: 326 participants
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
STCS - Baseline
|
Psychosocial assessments were performed through the psychosocial questionnaire (PSQ) that were sent out to patients at time of wait listing. Information about infectious disease, cancer, causes of ... | 2008-05 | |
| 1 |
STCS - Follow-up 1
|
Psychosocial assessments were performed through the psychosocial questionnaire (PSQ). Information about infectious disease, cancer, causes of death, organ function, immunologic events and causes ... | 2008-11 | |
| 2 |
STCS - Follow-up 2
|
Psychosocial assessments were performed through the psychosocial questionnaire (PSQ). Information about infectious disease, cancer, causes of death, organ function, immunologic events and causes ... | 2009-05 | |
| 3 |
STCS - Follow-up 3
|
Psychosocial assessments were performed through the psychosocial questionnaire (PSQ). Information about infectious disease, cancer, causes of death, organ function, immunologic events and causes ... | 2010-05 | |
| 4 |
STCS - Follow-up 4
|
Psychosocial assessments were performed through the psychosocial questionnaire (PSQ). Information about infectious disease, cancer, causes of death, organ function, immunologic events and causes ... | 2011-05 | |
| 5 |
STCS - Follow-up 5
|
Psychosocial assessments were performed through the psychosocial questionnaire (PSQ). Information about infectious disease, cancer, causes of death, organ function, immunologic events and causes ... | 2012-05 | |
| 6 |
STCS - Follow-up 6
|
Psychosocial assessments were performed through the psychosocial questionnaire (PSQ). Information about infectious disease, cancer, causes of death, organ function, immunologic events and causes ... | 2013-05 | |
| 7 |
STCS - Follow-up 7
|
Psychosocial assessments were performed through the psychosocial questionnaire (PSQ). Information about infectious disease, cancer, causes of death, organ function, immunologic events and causes ... | 2014-05 | |
| 8 |
STCS - Follow-up 8
|
Psychosocial assessments were performed through the psychosocial questionnaire (PSQ). Information about infectious disease, cancer, causes of death, organ function, immunologic events and causes ... | 2015-05 | |
| 9 |
STCS - Follow-up 9
|
Psychosocial assessments were performed through the psychosocial questionnaire (PSQ). Information about infectious disease, cancer, causes of death, organ function, immunologic events and causes ... | 2016-05 | |
| 10 |
STCS - Follow-up 10
|
Psychosocial assessments were performed through the psychosocial questionnaire (PSQ). Information about infectious disease, cancer, causes of death, organ function, immunologic events and causes ... | 2017-05 | |
| 11 |
STCS - Follow-up 11
|
Psychosocial assessments were performed through the psychosocial questionnaire (PSQ). Information about infectious disease, cancer, causes of death, organ function, immunologic events and causes ... | 2018-05 | |
| 12 |
STCS - Follow-up 12
|
Psychosocial assessments were performed through the psychosocial questionnaire (PSQ). Information about infectious disease, cancer, causes of death, organ function, immunologic events and causes ... | 2019-05 | |
| 13 |
STCS - Follow-up 13
|
Psychosocial assessments were performed through the psychosocial questionnaire (PSQ). Information about infectious disease, cancer, causes of death, organ function, immunologic events and causes ... | 2020-05 | |
| 14 |
STCS - Follow-up 14
|
Psychosocial assessments were performed through the psychosocial questionnaire (PSQ). Information about infectious disease, cancer, causes of death, organ function, immunologic events and causes ... | 2021-05 | |
| 15 |
STCS - Follow-up 15
|
Psychosocial assessments were performed through the psychosocial questionnaire (PSQ). Information about infectious disease, cancer, causes of death, organ function, immunologic events and causes ... | 2022-05 | |
| 16 |
STCS - Follow-up 16
|
Psychosocial assessments were performed through the psychosocial questionnaire (PSQ). Information about infectious disease, cancer, causes of death, organ function, immunologic events and causes ... | 2023-05 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
- Cognitive functioning
- Personality
- Psychological distress and emotions
- Other psychological measures and assessments
- Perception of health
- Quality of life
- Life course development
- Functional limitations
- Other perception of health, quality of life and functional limitation-related information
Socio-demographic and economic characteristics
Age/birthdate
Sex/gender
Marital/partner status
Family and household structure
Education
Ethnicity, race and religion
Labour force and retirement
Income, possessions, and benefits
Other socio-demographic and economic characteristics
Lifestyle and behaviours
Tobacco
Alcohol
Drugs
Physical activity
Sleep
Other and unspecified lifestyle information
Birth, pregnancy and reproductive health history
Pregnancy, delivery and birth
Perception of health, quality of life, development and functional limitations
Perception of health
Quality of life
Use of assistive devices
Diseases
Certain infectious and parasitic diseases (A00-B99)
Neoplasms (C00-D48)
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
Endocrine, nutritional and metabolic diseases (E00-E90)
Diseases of the nervous system (G00-G99)
Diseases of the circulatory system (I00-I99)
Diseases of the respiratory system (J00-J99)
Diseases of the digestive system (K00-K93)
Diseases of the musculoskeletal system and connective tissue (M00-M99)
Injury, poisoning and certain other consequences of external causes (S00-T98)
Diseases without precise specification or falling into multiple categories
Symptoms and signs
Symptoms and signs involving the digestive system and abdomen (R10-R19)
Symptoms and signs involving the urinary system (R30-R39)
Symptoms related to multiple categories
Medication and supplements
Medication and supplement intake
Posology and protocol of administration
Other and unspecified pharmacological interventions
Non-pharmacological interventions
Surgical interventions
Radiological interventions
Laboratory diagnosis interventions
Other and unspecified non-pharmacological interventions
Health and community care services utilization
Visits to health professionals
Hospitalizations
Other health and community care
Death
Vital status
Cause of death
Other end of life or death-related information
Physical measures and assessments
Anthropometry
Circulation and respiration
Muscles, skeleton and mobility
Digestion
Other physical measures and assessments
Laboratory measures
Biochemistry
Microbiology
Virology
Immunology
Histology
Other laboratory measures
Cognition, personality and psychological measures and assessments
Psychological distress and emotions
Life events, life plans, beliefs and values
Beliefs and values
Physical environment
Radiation exposure
Administrative information
Identifiers
Date and time-related information
Questionnaire and interview-related information
Physical and cognitive measure and biosample-related information
Data and sample collection center-related information
Other administrative information
Psychological distress and emotions
Hospital Anxiety and Depression Scale
Quality of life
EuroQol Five Dimensions Questionnaire