Individual Study / SMSC

The Swiss Multiple Sclerosis Cohort-Study
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The Swiss Multiple Sclerosis Cohort-Study

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Datasets -
Variables -
Start Year
2010
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Investigators Contacts
  • Dr. Jens Kuhle
    University of Basel
  • Dr. Jens Kuhle
    University of Basel
  • Dr. Pascal Benkert
    University of Basel

Design

Study design
Cohort
Follow Up

Every participant is followed-up every 6 or 12 months +/-45 days as judged by the treating physician.

Marker Paper

Disanto G, Benkert P, Lorscheider J, et al. The Swiss Multiple Sclerosis Cohort-Study (SMSC): A Prospective Swiss Wide Investigation of Key Phases in Disease Evolution and New Treatment Options. PLoS One. 2016 31;11(3):e0152347.

PUBMED 27032105

Recruitment

Recruitment Target
  • Individuals

Number of Participants

Number of Participants
No Limit
Number of Participants with Biological Samples
No Limit
Supplementary Information

As of 6 January 2022, there are 1554 participants enrolled in the study.

Access

Availability of data and biosamples

Possible Access to Data
Possible Access to Biosamples
Other
Yes
No
Not applicable
Don't know

Timeline

SMSC population

Selection Criteria
Newborns
Twins
Countries
  • Switzerland
Territory
Aarau, Basel, Berne, Geneva, Lausanne, Lugano, St. Gallen, Zurich
Ethnic Origin
Health Status

  • Patients must be diagnosed with relapsing-remitting, primary progressive, or secondary progressive MS according to the 2010 revised McDonald criteria or previously established criteria (McDonald or Poser). Patients diagnosed with a clinically isolated syndrome, radiologically isolated syndrome, or neuromyelitis optica can also be included.

Other Criteria

Patients who do not receive immunomodulatory (DMD) treatment, who need to begin or switch a DMD as judged by the treating physician, who start or switch a DMD, or who are already treated with natalizumab or fingolimod are included.

Recruitment

Sources of recruitment
  • Specific population
Specific Population
  • Clinic patients
Supplementary Information
Participants are recruited from any of the eight study centres: the Cantonal Hospital of Aarau, the University Hospitals of Basel, Berne, Geneva, Lausanne and Zurich, the Regional Hospital of Lugano, and the Cantonal Hospital of St. Gallen.

Number of Participants

Number of Participants
No Limit
Number of Participants with Biological Samples
No Limit
Supplementary Information about selection criteria
Data Collection Events
# Name Description Start End
0 SMSC - Baseline Information is collected about sociodemographic characteristics (sex, date of birth, ethnicity), pregnancy history, family history of MS, date of first MS symptom, date of the second relapse, ... 2012-06
1 SMSC - Follow-up 6 months Information is collected about sociodemographic characteristics (sex, date of birth, ethnicity), pregnancy history, family history of MS, date of first MS symptom, date of the second relapse, ... 2012-12
2 SMSC - Follow-up 12 months Information is collected about sociodemographic characteristics (sex, date of birth, ethnicity), pregnancy history, family history of MS, date of first MS symptom, date of the second relapse, ... 2013-06
3 SMSC - Follow-up 18 months Information is collected about sociodemographic characteristics (sex, date of birth, ethnicity), pregnancy history, family history of MS, date of first MS symptom, date of the second relapse, ... 2013-12
4 SMSC - Follow-up 24 months Information is collected about sociodemographic characteristics (sex, date of birth, ethnicity), pregnancy history, family history of MS, date of first MS symptom, date of the second relapse, ... 2014-06
5 SMSC - Follow-up 30 months Information is collected about sociodemographic characteristics (sex, date of birth, ethnicity), pregnancy history, family history of MS, date of first MS symptom, date of the second relapse, ... 2014-12
6 SMSC - Follow-up 36 months Information is collected about sociodemographic characteristics (sex, date of birth, ethnicity), pregnancy history, family history of MS, date of first MS symptom, date of the second relapse, ... 2015-06
7 SMSC - Follow-up 42 months Information is collected about sociodemographic characteristics (sex, date of birth, ethnicity), pregnancy history, family history of MS, date of first MS symptom, date of the second relapse, ... 2015-12
8 SMSC - Follow-up 48 months Information is collected about sociodemographic characteristics (sex, date of birth, ethnicity), pregnancy history, family history of MS, date of first MS symptom, date of the second relapse, ... 2016-06
9 SMSC - Follow-up 54 months Information is collected about sociodemographic characteristics (sex, date of birth, ethnicity), pregnancy history, family history of MS, date of first MS symptom, date of the second relapse, ... 2016-12
10 SMSC - Follow-up 60 months Information is collected about sociodemographic characteristics (sex, date of birth, ethnicity), pregnancy history, family history of MS, date of first MS symptom, date of the second relapse, ... 2017-06
11 SMSC - Follow-up 66 months Information is collected about sociodemographic characteristics (sex, date of birth, ethnicity), pregnancy history, family history of MS, date of first MS symptom, date of the second relapse, ... 2017-12
12 SMSC - Follow-up 72 months Information is collected about sociodemographic characteristics (sex, date of birth, ethnicity), pregnancy history, family history of MS, date of first MS symptom, date of the second relapse, ... 2018-06
13 SMSC - Follow-up 78 months Information is collected about sociodemographic characteristics (sex, date of birth, ethnicity), pregnancy history, family history of MS, date of first MS symptom, date of the second relapse, ... 2018-12
14 SMSC - Follow-up 84 months Information is collected about sociodemographic characteristics (sex, date of birth, ethnicity), pregnancy history, family history of MS, date of first MS symptom, date of the second relapse, ... 2019-06
15 SMSC - Follow-up 90 months Information is collected about sociodemographic characteristics (sex, date of birth, ethnicity), pregnancy history, family history of MS, date of first MS symptom, date of the second relapse, ... 2019-12
16 SMSC - Follow-up 96 months Information is collected about sociodemographic characteristics (sex, date of birth, ethnicity), pregnancy history, family history of MS, date of first MS symptom, date of the second relapse, ... 2020-06
17 SMSC - Follow-up 102 months Information is collected about sociodemographic characteristics (sex, date of birth, ethnicity), pregnancy history, family history of MS, date of first MS symptom, date of the second relapse, ... 2020-12
18 SMSC - Follow-up 108 months Information is collected about sociodemographic characteristics (sex, date of birth, ethnicity), pregnancy history, family history of MS, date of first MS symptom, date of the second relapse, ... 2021-06
19 SMSC - Follow-up 114 months Information is collected about sociodemographic characteristics (sex, date of birth, ethnicity), pregnancy history, family history of MS, date of first MS symptom, date of the second relapse, ... 2021-12
20 SMSC - Follow-up 120 months Information is collected about sociodemographic characteristics (sex, date of birth, ethnicity), pregnancy history, family history of MS, date of first MS symptom, date of the second relapse, ... 2022-06

Classifications

Socio-demographic and economic characteristics
Lifestyle and behaviours
Birth, pregnancy and reproductive health history
Perception of health, quality of life, development and functional limitations
Diseases
Symptoms and signs
Medication and supplements
Non-pharmacological interventions
Health and community care services utilization
Death
Physical measures and assessments
Laboratory measures
Cognition, personality and psychological measures and assessments
Life events, life plans, beliefs and values
Preschool, school and work life
Social environment and relationships
Physical environment
Administrative information
Perception of health
Quality of life
Life course development
Functional limitations
Other perception of health, quality of life and functional limitation-related information

Socio-demographic and economic characteristics

Age/birthdate
Sex/gender
Family and household structure
Residence
Ethnicity, race and religion

Birth, pregnancy and reproductive health history

Pregnancy, delivery and birth

Perception of health, quality of life, development and functional limitations

Functional limitations

Diseases

Diseases of the nervous system (G00-G99)
Pregnancy, childbirth and the puerperium (O00-O9A)
Diseases without precise specification or falling into multiple categories

Symptoms and signs

Symptoms related to multiple categories

Medication and supplements

Medication and supplement intake
Posology and protocol of administration

Non-pharmacological interventions

Other and unspecified non-pharmacological interventions

Death

Vital status
Cause of death

Physical measures and assessments

Physical characteristics
Anthropometry
Muscles, skeleton and mobility
Brain and nerves

Laboratory measures

Hematology
Biochemistry
Virology
Immunology

Administrative information

Identifiers
Date and time-related information
Questionnaire and interview-related information
Physical and cognitive measure and biosample-related information
Data and sample collection center-related information
Other administrative information

Functional limitations

Expanded Disability Status Scale