Signature Biobank - Banks of biological, psychosocial and clinical data on people suffering from mental health problems
Networks
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Datasets
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Variables
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The objectives of the study are:
* To advance mental health research.
* To assess the physical and mental health of volunteers admitted to the Montreal Mental Health University Institute.
* To enable clinicians to tailor treatment based on meaningful psychosocial and medical indicators.
It aims to collect, on the one hand, medical and psychosocial data and, on the other hand, human biological material from users consenting to participate in the project and from the brief intervention programs (emergency), the psychotic disorders program and the mood disorders program of the Montreal Mental Health University Institute.
- Start Year
- 2012
- End Year
- 2021
- Supplementary Information
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**Papers of Interest**
L. Dion-Albert, A. Cadoret, E. Doney, et al. Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue. Nat. Com. 13, 64 (2022)
V. Laliberté, C.-É. Giguère, S. Potvin, A. Lesage. Berkson's bias in biobank sampling in a specialized mental health care setting: a comparative cross-sectional study. BMJ Open 10(7):35088 July 2020
S. Potvin, L. Mahrouche, R. Assaf, et al. Furtos, R.Godbout on behalf of the Signature Consortium. Peripheral Endogenous Cannabinoid Levels Are Increased in Schizophrenia Patients Evaluated in a Psychiatric Emergency Setting. Front. Psychiatry, 30 June 2020
T. Lecomte, C.-É. Giguère, B. Cloutier, S. et al.Comorbidity Profiles of Psychotic Patients in Emergency Psychiatry. Journal of Dual Diagnosis, 2020 Jan Vol.16 (issue2) 260:270
M.-F. Marin, S. Geoffrion, C.-É. Giguère, et al.The Moderating Role of Age in the Relationship Between Early Life Adversity and Hair Cortisol Concentrations in Adults Admitted to a Psychiatric Emergency Service. Biological Psychiatry, 2019 May 85(10): S146-S147
Visit SIGNATURE
| Investigators | Contacts |
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Design
- Study design
- Cohort
- Follow Up
- **Mental Health Patients** Participants are followed-up at 4 different points in their clinical journey, ie. when entering the emergency room, during treatment in an inpatient unit and during recovery in an outpatient clinic. **Controls** After first recruitment, a sub-group of participants are followed up for a second time within a month and at between 2016 and 2021.
- Supplementary Information
- Study designs: Cohort and case-control
Marker Paper
S.J. Lupien, M. Sasseville, N. Francois, et al. Lesage and Signature Consortium. Stress 20, 2-18 (2017)
PUBMED 28124571
Recruitment
- Recruitment Target
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- Individuals
Number of Participants
- Number of Participants
- 2,322
- Number of Participants with Biological Samples
- 2,135
- Supplementary Information
- * Mental health patients: 2173 participants * Mental health patients with biosamples: 1986 participants * Controls: 149 partipants * Controls with biosamples: 149 participants
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Availability of access information
On the study website : https://criusmm.ciusss-estmtl.gouv.qc.ca/fr/pro...
By contacting the study representative
Sector of research
| Possible Access to Data | Possible Access to Biosamples | |
|---|---|---|
| Investigators from the public sector | ||
| Investigators from the private sector | ||
| Investigators from not-for-profit organization |
Researchers from the private sector needs to be a collaborator of one of the Signature consortium members.
Transfer
| Possible Access to Data | Possible Access to Biosamples | |
|---|---|---|
| Can leave the study facility | ||
| Can leave the country |
Cost
| Possible Access to Data | Fixed Cost |
| Possible Access to Biosamples | Fixed Cost |
Biological sample prices range from $20 to $40 per sample.
Cost reduction for co-analyses
| Possible Access to Data | |
| Possible Access to Biosamples |
Members of the Alliance santé mentale au Québec benefit from a reduction.
Supplementary Information
To access the data, a duly completed request form, REB approval, a study protocol, and approval from the Signature Access Committee are required.
Timeline
Populations
The population is composed of patients admitted to the emergency room of the Hôpital Louis Lafontaine (Montreal, Canada).
Selection Criteria
- Minimum age
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18
- Maximum age
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81
- Newborns
- Twins
- Countries
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- Canada
- Territory
- Montreal
- Ethnic Origin
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- Health Status
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- Participants are patients who had a mental crisis.
- Other Criteria
- Participants admitted to one of two programs targeted by the project: the anxiety and mood disorder (AMD) program or the first psychotic episode (FPE) program are elligibale for the second (T2), third (T3) and fourth (T4) follow up. Pregnant women are excluded.
Recruitment
- Sources of recruitment
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- Specific population
- Specific Population
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- Clinic patients
- Supplementary Information
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Patients were recruited from the psychiatric emergency of the Hôpital Louis Lafontaine emergency room.
Number of Participants
- Number of Participants
- 2,173
- Number of Participants with Biological Samples
- 1,986
- Supplementary Information about selection criteria
- **Mental Health Patients T1** * 2,173 participants * 1,986 biological samples **Mental Health Patients T2** * 885 participants * 885 biological samples **Mental Health Patients T3** * 793 participants * 779 biological samples **Mental Health Patients T4** * 473 participants * 473 biological samples
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
SIGNATURE - Mental Health Patients - T1
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Sociodemographic information including gender and sex identity, spiritual beliefs, social functioning, childhood experiences, and family background was collected. Information about family ... | 2012-11 | 2020-03 |
| 1 |
SIGNATURE - Mental Health Patients - T2
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Sociodemographic information including gender and sex identity, spiritual beliefs, social functioning, childhood experiences, and family background was also collected. Information about family ... | 2013-01 | 2020-03 |
| 2 |
SIGNATURE - Mental Health Patients - T3
|
Sociodemographic information including gender and sex identity, spiritual beliefs, social functioning, childhood experiences, and family background was also collected. Information about family ... | 2013-01 | 2020-10 |
| 3 |
SIGNATURE - Mental Health Patients - T4
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Sociodemographic information including gender and sex identity, spiritual beliefs, social functioning, childhood experiences, and family background was also collected. Information about family ... | 2014-02 | 2021-03 |
The population is composed of Canadian age-matched control participants recruited in the Montreal East area without any known mental disorder.
Selection Criteria
- Minimum age
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18
- Maximum age
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81
- Newborns
- Twins
- Countries
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- Canada
- Territory
- East part of the Montreal Island
- Ethnic Origin
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- Health Status
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- Other Criteria
- The control group was locally recruited to match age, sex and economic status of the patient cohort. Pregnant women are excluded.
- Supplementary Information about selection criteria
Recruitment
- Sources of recruitment
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- General population
- General Population
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- Volunteer enrolment
- Supplementary Information
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Participants are voluntary patients recruited within the communities of the eastern part of the Montreal Island.
Number of Participants
- Number of Participants
- 149
- Number of Participants with Biological Samples
- 149
- Supplementary Information about selection criteria
- A sub-group of 30 had a second follow-up T2 (within 1 month after first recruitment).
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
SIGNATURE - Controls - T1
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Sociodemographic information including gender and sex identity, spiritual beliefs, social functioning, childhood experiences, and family background was also collected. Information about family ... | 2016-09 | 2020-03 |
| 1 |
SIGNATURE - Controls - T2
|
Sociodemographic information including gender and sex identity, spiritual beliefs, social functioning, childhood experiences, and family background was also collected. Information about family ... | 2016-09 | 2020-03 |
| 2 |
SIGNATURE - Controls - T4
|
Sociodemographic information including gender and sex identity, spiritual beliefs, social functioning, childhood experiences, and family background was also collected. Information about family ... | 2016-02 | 2021-03 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
- Cognitive functioning
- Personality
- Psychological distress and emotions
- Other psychological measures and assessments
- Life events
- Beliefs and values
- Perception of health
- Quality of life
- Life course development
- Functional limitations
- Other perception of health, quality of life and functional limitation-related information
- Tobacco
- Alcohol
- Drugs
- Nutrition
- Breastfeeding
- Physical activity
- Sleep
- Sexual behaviours and orientation
- Technological devices
- Misbehaviour and criminality
- Other and unspecified lifestyle information
Socio-demographic and economic characteristics
Age/birthdate
Sex/gender
Twin
Marital/partner status
Family and household structure
Education
Residence
Citizenship and immigrant status
Ethnicity, race and religion
Language
Labour force and retirement
Income, possessions, and benefits
Other socio-demographic and economic characteristics
Lifestyle and behaviours
Tobacco
Alcohol
Drugs
Sleep
Sexual behaviours and orientation
Misbehaviour and criminality
Other and unspecified lifestyle information
Birth, pregnancy and reproductive health history
Puberty, menstruation, menopause and andropause
Perception of health, quality of life, development and functional limitations
Functional limitations
Diseases
Neoplasms (C00-D48)
Endocrine, nutritional and metabolic diseases (E00-E90)
Mental and behavioural disorders (F00-F99)
Diseases of the nervous system (G00-G99)
Diseases of the circulatory system (I00-I99)
Diseases of the respiratory system (J00-J99)
Diseases of the digestive system (K00-K93)
Diseases of the musculoskeletal system and connective tissue (M00-M99)
Injury, poisoning and certain other consequences of external causes (S00-T98)
External causes of morbidity and mortality (V01-Y98)
Diseases without precise specification or falling into multiple categories
Symptoms and signs
Symptoms and signs involving the urinary system (R30-R39)
Medication and supplements
Medication and supplement intake
Health and community care services utilization
Hospitalizations
Physical measures and assessments
Anthropometry
Circulation and respiration
Laboratory measures
Biochemistry
Cognition, personality and psychological measures and assessments
Personality
Psychological distress and emotions
Life events, life plans, beliefs and values
Life events
Beliefs and values
Administrative information
Identifiers
Physical and cognitive measure and biosample-related information
Other administrative information
Personality
Brown-Goodwin Lifetime History of Aggression Scale
Urgency, Premeditation, Perseverance, Sensation Seeking, Positive Urgency, Impulsive Behavior Scale
Psychological distress and emotions
Patient Health Questionnaire
Psychosis Screening Questionnaire
Psychotic Symptom Rating Scales
Suicide Behaviour Questionnaire
Spielberger State-Trait Anxiety Inventory
Life events
Childhood Experiences of Violence Questionnaire
Functional limitations
World Health Organization Disability Assessment Schedule
Alcohol
Alcohol Use Disorders Identification Test
Drugs
Alcohol, Smoking and Substance Involvement Screening Test
Cannabis Abuse Screening Test
Drug abuse screening test
Sleep
Sleep Habits Questionnaire