A Multifaceted Community-Family-Mother-Child Intervention Study for the Prevention of Childhood Obesity: The Life Tree Study
- Start Year
- 2019
- End Year
- 2028
- Supplementary Information
- More information on the HeLTI consortium is available at https://helti.org/
Visit SCHeLTI-LIFE TREE
| Investigators | Contacts |
|---|---|
|
|
Design
- Study design
- Clinical trial
- Follow Up
- Women can be recruited either starting at preconception or in the first trimester. After the baseline preconception collection, women who were not pregnant at the time of recruitment are followed up at most three times within one year of enrollment or until conception. Then mothers are followed up twice during pregnancy (15 to 28 weeks and 29 to 36 weeks), once at delivery, and seven times postpartum (at 3, 6, 12, 24, 36, 48, and 60 months). After the baseline preconception collection, fathers are followed up once at pregnancy (29 to 36 weeks). After delivery, children are followed up six times postpartum (at 3, 6, 12, 24, 36, 48, and 60 months).
Marker Paper
Wu Y, Marc I, Bouchard L, et al. Study protocol for the Sino-Canadian Healthy Life Trajectories Initiative (SCHeLTI): a multicentre, cluster-randomised, parallel-group, superiority trial of a multifaceted community-family-mother-child intervention to prevent childhood overweight and obesity. BMJ Open. 2021;11(4):e045192.
PUBMED 33795307
Recruitment
- Recruitment Target
-
- Families
Number of Participants
- Number of Participants
- 13,500
- Number of Participants with Biological Samples
- 13,500
- Supplementary Information
-
Mothers: 4500 participants
Fathers: 4500 participants
Children: 4500 participants
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Timeline
Populations
Selection Criteria
- Sex
-
Women
- Minimum age
-
20
- Maximum age
-
42
- Pregnant Women
-
- First trimester
- Newborns
- Twins
- Countries
-
- China
- Territory
- Shanghai
- Ethnic Origin
-
- Health Status
-
- Women are excluded from the study if they have HIV, Hepatitis B, Hepatitis C, major heart conditions, thalassemia major, cystic fibrosis, pre-existing type 1 diabetes mellitus, type 2 diabetes mellitus, or chronic medication-dependant hypertension.
- Other Criteria
- Participating women must be Mandarin speakers and less than 14 weeks pregnant. Women are excluded if they plan to move out participating Shanghai districts chosen for the study within five years, abuse drugs, or have multiple pregnancies.
- Supplementary Information about selection criteria
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Participants are recruited from one of the 42 maternal child health units located within the four designated Shanghai districts.
Number of Participants
- Number of Participants
- 2,250
- Number of Participants with Biological Samples
- 2,250
- Supplementary Information about selection criteria
-
Nonpregnant women: 900 participants
Pregnant women (< 14 weeks): 1350 participants50% of 900 nonpregnant participants are expected to achieve a viable pregnancy within 1 year of enrolment and continue prenatal follow-up with the study.
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
SCHeLTI-LIFE TREE - Mothers Intervention - Preconception Baseline
|
Information is collected about sociodemographic characteristics (age, birthplace, marital status, household structure, employment, annual household income, and education), medical history and ... | 2019 | 2022 |
| 1 |
SCHeLTI-LIFE TREE - Mothers Intervention - Preconception 3 months after enrolment
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, annual household income, and education), medical history and medication use, ... | 2019 | 2022 |
| 2 |
SCHeLTI-LIFE TREE - Mothers Intervention - Preconception 6 months after enrolment
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, annual household income, and education), medical history and medication use, ... | 2019 | 2022 |
| 3 |
SCHeLTI-LIFE TREE - Mothers Intervention - Preconception 9 months after enrolment
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, annual household income, and education), medical history and medication use, ... | 2019 | 2022 |
| 4 |
SCHeLTI-LIFE TREE - Mothers Intervention - Preconception 12 months after enrolment
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, annual household income, and education), medical history and medication use, ... | 2020 | 2023 |
| 5 |
SCHeLTI-LIFE TREE - Mothers Intervention - Pregnancy under 14 weeks
|
Information is collected about sociodemographic characteristics (age, birthplace, marital status, household structure, employment, annual household income, and education), medical history and ... | 2019 | 2022 |
| 6 |
SCHeLTI-LIFE TREE - Mothers Intervention - Pregnancy 15 to 28 weeks
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, and annual household income), medical history and medication use, hospitalization, ... | 2019 | 2023 |
| 7 |
SCHeLTI-LIFE TREE - Mothers Intervention - Pregnancy 29 to 36 weeks
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, and annual household income), medical history and medication use, hospitalization, ... | 2019 | 2023 |
| 8 |
SCHeLTI-LIFE TREE - Mothers Intervention - Delivery 0 to 7 days
|
Information about delivery details and any delivery complications such as ICU admissions, birth trauma, infections, and pre-eclampsia is collected. Information is also collected about medication ... | 2019 | 2023 |
| 9 |
SCHeLTI-LIFE TREE - Mothers Intervention - 6 weeks postpartum
|
Information is collected about COVID-19 (symptoms, diagnosis, employment status), breastfeeding (Breastfeeding Self-Efficacy Scale), and hospitalization. Weight and blood pressure measurements ... | 2019 | 2023 |
| 10 |
SCHeLTI-LIFE TREE - Mothers Intervention - 3 months postpartum
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, annual household income, and childcare), medical history and medication use, ... | 2020 | 2024 |
| 11 |
SCHeLTI-LIFE TREE - Mothers Intervention - 6 months postpartum
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, annual household income, and childcare), medical history and medication use, ... | 2020 | 2024 |
| 12 |
SCHeLTI-LIFE TREE - Mothers Intervention - 12 months postpartum
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, annual household income, and childcare), medical history and medication use, ... | 2020 | 2024 |
| 13 |
SCHeLTI-LIFE TREE - Mothers Intervention - 24 months postpartum
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, annual household income, and childcare), medical history and medication use, ... | 2021 | 2025 |
| 14 |
SCHeLTI-LIFE TREE - Mothers Intervention - 36 months postpartum
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, annual household income, and childcare), medical history and medication use, ... | 2022 | 2026 |
| 15 |
SCHeLTI-LIFE TREE - Mothers Intervention - 48 months postpartum
|
Weight and blood pressure measurements are collected. | 2023 | 2027 |
| 16 |
SCHeLTI-LIFE TREE - Mothers Intervention - 60 months postpartum
|
Information is collected about sociodemographic characteristics (age, birthplace, marital status, household structure, employment, annual household income, and education), medical history and ... | 2024 | 2028 |
| 17 |
SCHeLTI-LIFE TREE - Mothers Intervention - Additional data collections as needed
|
Information is collected about depression (Patient Health Questionnaire 9, Edinburgh Postnatal Depression Scale), anxiety (Generalized Anxiety Disorder-7), medication, COVID-19 infections (impact ... | 2019 | 2028 |
Selection Criteria
- Sex
-
Women
- Minimum age
-
20
- Maximum age
-
42
- Pregnant Women
-
- First trimester
- Newborns
- Twins
- Countries
-
- China
- Territory
- Shanghai
- Ethnic Origin
-
- Health Status
-
- Women are excluded from the study if they have HIV, Hepatitis B, Hepatitis C, major heart conditions, thalassemia major, cystic fibrosis, pre-existing type 1 diabetes mellitus, type 2 diabetes mellitus, or chronic medication-dependant hypertension.
- Other Criteria
- Participating women must be Mandarin speakers and less than 14 weeks pregnant. Women are excluded if they plan to move out participating Shanghai districts chosen for the study within five years, abuse drugs, or have multiple pregnancies.
- Supplementary Information about selection criteria
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Participants are recruited from one of the 42 maternal child health units located within the four designated Shanghai districts.
Number of Participants
- Number of Participants
- 2,250
- Number of Participants with Biological Samples
- 2,250
- Supplementary Information about selection criteria
-
Nonpregnant women: 900 participants
Pregnant women (< 14 weeks): 1350 participants50% of 900 nonpregnant participants are expected to achieve a viable pregnancy within 1 year of enrolment and continue prenatal follow-up with the study.
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
SCHeLTI-LIFE TREE - Mothers Control - Preconception Baseline
|
Information is collected about sociodemographic characteristics (age, birthplace, marital status, household structure, employment, annual household income, and education), medical history and ... | 2019 | 2022 |
| 1 |
SCHeLTI-LIFE TREE - Mothers Control - Preconception 3 months after enrolment
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, annual household income, and education), medical history and medication use, ... | 2019 | 2022 |
| 2 |
SCHeLTI-LIFE TREE - Mothers Control - Preconception 6 months after enrolment
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, annual household income, and education), medical history and medication use, ... | 2019 | 2022 |
| 3 |
SCHeLTI-LIFE TREE - Mothers Control - Preconception 9 months after enrolment
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, annual household income, and education), medical history and medication use, ... | 2019 | 2022 |
| 4 |
SCHeLTI-LIFE TREE - Mothers Control - Preconception 12 months after enrolment
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, annual household income, and education), medical history and medication use, ... | 2020 | 2023 |
| 5 |
SCHeLTI-LIFE TREE - Mothers Control - Pregnancy under 14 weeks
|
Information is collected about sociodemographic characteristics (age, birthplace, marital status, household structure, employment, annual household income, and education), medical history and ... | 2019 | 2022 |
| 6 |
SCHeLTI-LIFE TREE - Mothers Control - Pregnancy 15 to 28 weeks
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, and annual household income), medical history and medication use, hospitalization, ... | 2019 | 2023 |
| 7 |
SCHeLTI-LIFE TREE - Mothers Control - Pregnancy 29 to 36 weeks
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, and annual household income), medical history and medication use, hospitalization, ... | 2019 | 2023 |
| 8 |
SCHeLTI-LIFE TREE - Mothers Control - Delivery 0 to 7 days
|
Information about delivery details and any delivery complications such as ICU admissions, birth trauma, infections, and pre-eclampsia is collected. Information is also collected about medication ... | 2019 | 2023 |
| 9 |
SCHeLTI-LIFE TREE - Mothers Control - 6 weeks postpartum
|
Information is collected about COVID-19 (symptoms, diagnosis, employment status), breastfeeding (Breastfeeding Self-Efficacy Scale), and hospitalization. Weight and blood pressure measurements ... | 2019 | 2023 |
| 10 |
SCHeLTI-LIFE TREE - Mothers Control - 3 months postpartum
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, annual household income, and childcare), medical history and medication use, ... | 2020 | 2024 |
| 11 |
SCHeLTI-LIFE TREE - Mothers Control - 6 months postpartum
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, annual household income, and childcare), medical history and medication use, ... | 2020 | 2024 |
| 12 |
SCHeLTI-LIFE TREE - Mothers Control - 12 months postpartum
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, annual household income, and childcare), medical history and medication use, ... | 2020 | 2024 |
| 13 |
SCHeLTI-LIFE TREE - Mothers Control - 24 months postpartum
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, annual household income, and childcare), medical history and medication use, ... | 2021 | 2025 |
| 14 |
SCHeLTI-LIFE TREE - Mothers Control - 36 months postpartum
|
Information is collected about sociodemographic characteristics (marital status, household structure, employment, annual household income, and childcare), medical history and medication use, ... | 2022 | 2026 |
| 15 |
SCHeLTI-LIFE TREE - Mothers Control - 48 months postpartum
|
Weight and blood pressure measurements are collected. | 2023 | 2027 |
| 16 |
SCHeLTI-LIFE TREE - Mothers Control - 60 months postpartum
|
Information is collected about sociodemographic characteristics (age, birthplace, marital status, household structure, employment, annual household income, and education), medical history and ... | 2024 | 2028 |
| 17 |
SCHeLTI-LIFE TREE - Mothers Control - Additional data collections as needed
|
Information is collected about depression (Patient Health Questionnaire 9, Edinburgh Postnatal Depression Scale), anxiety (Generalized Anxiety Disorder-7), medication, COVID-19 infections (impact ... | 2019 | 2028 |
Selection Criteria
- Sex
-
Men
- Newborns
- Twins
- Countries
-
- China
- Territory
- Shanghai
- Ethnic Origin
-
- Health Status
-
- Other Criteria
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
-
- Other specific population : Fathers of participating children.
Number of Participants
- Number of Participants
- 2,250
- Number of Participants with Biological Samples
- 2,250
Data Collection Event
- Start Date
-
2019
- End Date
-
2028
- Data sources
-
- Questionnaires
- Physical measures
- Biosamples
- Data sources - Biosamples
-
- Blood
Selection Criteria
- Sex
-
Men
- Newborns
- Twins
- Countries
-
- China
- Territory
- Shanghai
- Ethnic Origin
-
- Health Status
-
- Other Criteria
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
-
- Other specific population : Fathers of participating children.
Number of Participants
- Number of Participants
- 2,250
- Number of Participants with Biological Samples
- 2,250
Data Collection Event
- Start Date
-
2019
- End Date
-
2028
- Data sources
-
- Questionnaires
- Physical measures
- Biosamples
- Data sources - Biosamples
-
- Blood
Selection Criteria
- Newborns
- Twins
- Countries
-
- China
- Territory
- Shanghai
- Ethnic Origin
-
- Health Status
-
- Children are excluded if they have any major malformations in utero.
- Other Criteria
- Children born as a result of a multiple pregnancy are excluded.
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
-
- Other specific population : Children of participating mothers
Number of Participants
- Number of Participants
- 2,250
- Number of Participants with Biological Samples
- 2,250
- Supplementary Information about selection criteria
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
SCHeLTI-LIFE TREE - Children Intervention - Delivery 0 to 7 days
|
Information is collected about the date of birth, sex, breastfeeding, NICU admission, vaccination, birth trauma, medication, and adverse events (death and diseases). Birth length, birth weight ... | 2019 | 2023 |
| 1 |
SCHeLTI-LIFE TREE - Children Intervention - 6 weeks postpartum
|
Information is collected about medical history and medication use, adverse events (death and diseases), secondhand smoke exposure, nutrition, and breastfeeding. Length, weight, head ... | 2019 | 2023 |
| 2 |
SCHeLTI-LIFE TREE - Children Intervention - 3 months postpartum
|
Information is collected about medical history and medication use, adverse events (death and diseases), secondhand smoke exposure, nutrition, breastfeeding, screentime, sleep (Brief Infant Sleep ... | 2020 | 2024 |
| 3 |
SCHeLTI-LIFE TREE - Children Intervention - 6 months postpartum
|
Information is collected about medical history and medication use, adverse events (death and diseases), secondhand smoke exposure, nutrition, breastfeeding, screentime, sleep (Brief Infant Sleep ... | 2020 | 2024 |
| 4 |
SCHeLTI-LIFE TREE - Children Intervention - 12 months postpartum
|
Information is collected about medical history and medication use, adverse events (death and diseases), secondhand smoke exposure, nutrition, breastfeeding, screentime, sleep (Brief Infant Sleep ... | 2020 | 2024 |
| 5 |
SCHeLTI-LIFE TREE - Children Intervention - 24 months postpartum
|
Information is collected about medical history and medication use, adverse events (death and diseases), secondhand smoke exposure, breastfeeding, screentime, physical activity, sleep (Brief Infant ... | 2021 | 2025 |
| 6 |
SCHeLTI-LIFE TREE - Children Intervention - 36 months postpartum
|
Information is collected about medical history and medication use, adverse events (death and diseases), secondhand smoke exposure, eating behaviour (Child Eating Behaviour Questionnaire), ... | 2022 | 2026 |
| 7 |
SCHeLTI-LIFE TREE - Children Intervention - 48 months postpartum
|
Information is collected about death and diseases. Height, weight, length, body composition, blood pressure, and waist and mid-upper arm circumference measurements are collected. | 2023 | 2027 |
| 8 |
SCHeLTI-LIFE TREE - Children Intervention - 60 months postpartum
|
Information is collected about medical history and medication use, adverse events (death and diseases), secondhand smoke exposure, nutrition, breastfeeding, screen time, physical activity, sleep ... | 2024 | 2028 |
| 9 |
SCHeLTI-LIFE TREE - Children Intervention - Additional data collections as needed
|
Information is collected about medication and adverse events. | 2019 | 2028 |
Selection Criteria
- Newborns
- Twins
- Countries
-
- China
- Territory
- Shanghai
- Ethnic Origin
-
- Health Status
-
- Children are excluded if they have any major malformations in utero.
- Other Criteria
- Children born as a result of a multiple pregnancy are excluded.
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
-
- Other specific population : Children of participating mothers
Number of Participants
- Number of Participants
- 2,250
- Number of Participants with Biological Samples
- 2,250
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
SCHeLTI-LIFE TREE - Children Control - Delivery 0 to 7 days
|
Information is collected about the date of birth, sex, breastfeeding, NICU admission, vaccination, birth trauma, medication, and adverse events (death and diseases). Birth length, birth weight ... | 2019 | 2023 |
| 1 |
SCHeLTI-LIFE TREE - Children Control - 6 weeks postpartum
|
Information is collected about medical history and medication use, adverse events (death and diseases), secondhand smoke exposure, nutrition, and breastfeeding. Length, weight, head ... | 2019 | 2023 |
| 2 |
SCHeLTI-LIFE TREE - Children Control - 3 months postpartum
|
Information is collected about medical history and medication use, adverse events (death and diseases), secondhand smoke exposure, nutrition, breastfeeding, screentime, sleep (Brief Infant Sleep ... | 2020 | 2024 |
| 3 |
SCHeLTI-LIFE TREE - Children Control - 6 months postpartum
|
Information is collected about medical history and medication use, adverse events (death and diseases), secondhand smoke exposure, nutrition, breastfeeding, screentime, sleep (Brief Infant Sleep ... | 2020 | 2024 |
| 4 |
SCHeLTI-LIFE TREE - Children Control - 12 months postpartum
|
Information is collected about medical history and medication use, adverse events (death and diseases), secondhand smoke exposure, nutrition, breastfeeding, screentime, sleep (Brief Infant Sleep ... | 2020 | 2024 |
| 5 |
SCHeLTI-LIFE TREE - Children Control - 24 months postpartum
|
Information is collected about medical history and medication use, adverse events (death and diseases), secondhand smoke exposure, breastfeeding, screentime, physical activity, sleep (Brief Infant ... | 2021 | 2025 |
| 6 |
SCHeLTI-LIFE TREE - Children Control - 36 months postpartum
|
Information is collected about medical history and medication use, adverse events (death and diseases), secondhand smoke exposure, eating behaviour (Child Eating Behaviour Questionnaire), ... | 2022 | 2026 |
| 7 |
SCHeLTI-LIFE TREE - Children Control - 48 months postpartum
|
Information is collected about death and diseases. Height, weight, length, body composition, blood pressure, and waist and mid-upper arm circumference measurements are collected. | 2023 | 2027 |
| 8 |
SCHeLTI-LIFE TREE - Children Control - 60 months postpartum
|
Information is collected about medical history and medication use, adverse events (death and diseases), secondhand smoke exposure, nutrition, breastfeeding, screen time, physical activity, sleep ... | 2024 | 2028 |
| 9 |
SCHeLTI-LIFE TREE - Children Control - Additional data collections as needed
|
Information is collected about medication and adverse events. | 2019 | 2028 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
- Cognitive functioning
- Personality
- Psychological distress and emotions
- Other psychological measures and assessments
- Life events
- Beliefs and values
- Perception of health
- Quality of life
- Life course development
- Functional limitations
- Other perception of health, quality of life and functional limitation-related information
- Tobacco
- Alcohol
- Drugs
- Nutrition
- Breastfeeding
- Physical activity
- Sleep
- Sexual behaviours and orientation
- Technological devices
- Misbehaviour and criminality
- Other and unspecified lifestyle information
Socio-demographic and economic characteristics
Lifestyle and behaviours
Birth, pregnancy and reproductive health history
Perception of health, quality of life, development and functional limitations
Diseases
Symptoms and signs
Medication and supplements
Non-pharmacological interventions
Health and community care services utilization
Death
Physical measures and assessments
Laboratory measures
Cognition, personality and psychological measures and assessments
Life events, life plans, beliefs and values
Preschool, school and work life
Social environment and relationships
Physical environment
Administrative information
Cognitive functioning
Personality
Psychological distress and emotions
Life events
Life course development
Nutrition
Breastfeeding
Physical activity
Sleep