Study of Asthma, Genes and the Environment
- to collect information about the home environment of children in Manitoba;
- to confirm the rate of asthma in Manitoban children and validate the tools used to diagnose asthma;
- to understand the differences in children's immune system that either predisposes or protects them from getting asthma;
- to explore genes that may play a role in children developing asthma; and
- to understand the relationship between genes and the environment in the development of asthma.
- Start Year
- 2002
Visit SAGE
| Investigators | Contacts |
|---|---|
|
|
Design
- Study design
- Case-control
- Follow Up
- After the baseline questionnaire, a subset of participants were recruited in a nested case-control study.
- Supplementary Information
Marker Paper
Kozyrskyj AL, HayGlass KT, Sandford AJ, Paré PD, Chan-Yeug M, Becker AB. 2009. A novel study design to investigate the early-life origins of asthma in children (SAGE study). Allergy; 64: 1185-1193.
PUBMED 19416140
Recruitment
- Recruitment Target
-
- Individuals
Number of Participants
- Number of Participants
- 723
- Number of Participants with Biological Samples
- 723
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Availability of access information
By contacting the study representative
Sector of research
| Possible Access to Data | Possible Access to Biosamples | |
|---|---|---|
| Investigators from the public sector | ||
| Investigators from the private sector | ||
| Investigators from not-for-profit organization |
Transfer
| Possible Access to Data | Possible Access to Biosamples | |
|---|---|---|
| Can leave the study facility | ||
| Can leave the country |
Cost
| Possible Access to Data | Variable Cost |
| Possible Access to Biosamples | Variable Cost |
Cost reduction for co-analyses
| Possible Access to Data | |
| Possible Access to Biosamples |
Timeline
Populations
Selection Criteria
- Minimum age
-
7
- Maximum age
-
8
- Newborns
- Twins
- Countries
-
- Canada
- Territory
- Manitoba
- Ethnic Origin
-
- Health Status
-
- Diagnosed asthma
Recruitment
- Sources of recruitment
-
- General population
- General Population
-
- Selected sample
- Supplementary Information
-
Children born in 1995 were identified from the provincial healthcare registry.
Number of Participants
- Number of Participants
- 246
- Number of Participants with Biological Samples
- 246
- Supplementary Information about selection criteria
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
SAGE - Baseline questionnaire
|
A one page survey was sent to the household of the cohort children to inquire about their health and home environment exposures. The survey collected information about the presence of asthma, ... |
2002 | 2002 |
| 1 |
SAGE - Nested case-control study
|
Following confirmation of asthma status by a pediatric allergist, different assessments were conducted in children included in the study. A detailed survey was administered to parents ... |
2002 | 2005 |
Selection Criteria
- Minimum age
-
7
- Maximum age
-
8
- Newborns
- Twins
- Countries
-
- Canada
- Territory
- Manitoba
- Ethnic Origin
-
- Health Status
-
- Healthy children or children with allergies but no asthma
Recruitment
- Sources of recruitment
-
- General population
- General Population
-
- Selected sample
- Supplementary Information
-
Children born in 1995 were identified from the provincial healthcare registry.
Number of Participants
- Number of Participants
- 477
- Number of Participants with Biological Samples
- 477
- Supplementary Information about selection criteria
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
SAGE - Baseline questionnaire
|
A one page survey was sent to the household of the cohort children to inquire about their health and home environment exposures. The survey collected information about the presence of asthma, ... |
2002 | 2002 |
| 1 |
SAGE - Nested case-control study
|
Following confirmation of asthma status by a pediatric allergist, different assessments were conducted in children included in the study. A detailed survey was administered to parents ... |
2002 | 2005 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
- Cognitive functioning
- Personality
- Psychological distress and emotions
- Other psychological measures and assessments
Socio-demographic and economic characteristics
Lifestyle and behaviours
Birth, pregnancy and reproductive health history
Perception of health, quality of life, development and functional limitations
Diseases
Symptoms and signs
Medication and supplements
Non-pharmacological interventions
Health and community care services utilization
Physical measures and assessments
Laboratory measures
Cognition, personality and psychological measures and assessments
Life events, life plans, beliefs and values
Preschool, school and work life
Social environment and relationships
Physical environment
Administrative information
Psychological distress and emotions