Respiratory Health in Northern Europe
Networks
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Datasets
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Variables
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The primary objective of this investigation was to study change in adults over a 20-year period in the prevalence of respiratory symptoms and disorders and its association to year of birth, lifestyle and sleep related variables. Secondary objectives included:
- to assess the incidence and remission rate of asthma and allergic rhinitis and to determine risk factors in a representative Nordic population sample;
- to assess the influence of occupational and home related environmental exposure on the development of asthma and allergic rhinitis in Northern Europe;
- to investigate the association between the menstrual cycle and asthmatic symptoms in women;
- to assess the incidence and remission of sleep disturbances and determine risk factors including atopy and asthma.
- Start Year
- 1990
- End Year
- 2012
- Supplementary Information
Visit RHINE
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Design
- Study design
- Cohort
- Follow Up
- Participants were followed-up twice over the span of 20 years.
- Supplementary Information
- Respiratory Health In Northern Europe study (RHINE) is a 10 year follow-up of participants in the European Community Respiratory Health Survey (ECRHS) from the Nordic countries, a total of 21802 subject born between 1945 and 1973 from Reykjavik(Iceland); Bergen(Norway); Aarhus(Denmark); Gothenburg, Uppsala, Umea (Sweden) and Tartu (Estonia). 11269 (6085 women and 5184 men) have participated in all three collection events. RHINE II 1999-2001 is a follow-up study of the participants from ECRHS stage 1 from seven Northern European centers: Reykjavik(Iceland); Bergen(Norway); Aarhus(Denmark); Gothenburg, Uppsala, Umea (Sweden) and Tartu (Estonia) and RHINE III 2010-2012, is a second follow-up performed in the same centers.
Marker Paper
Janson C, Johannessen A, Franklin K, et al. Change in the prevalence asthma, rhinitis and respiratory symptom over a 20 year period: associations to year of birth, life style and sleep related symptoms. BMC Pulm Med. 2018;18(1):152.
PUBMED 30208969
Recruitment
- Recruitment Target
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- Individuals
Number of Participants
- Number of Participants
- 21,802
- Number of Participants with Biological Samples
- Supplementary Information
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Register data available, but only for the Swedish part of the population. Air pollution data available for all centers based on geocoding.
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Supplementary Information
Timeline
RHINE population
The target population for the RHINE study were all subjects that participated in Stage 1 of the European Community Respiratory Health Survey (ECRHS).
Selection Criteria
- Minimum age
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20
- Maximum age
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44
- Newborns
- Twins
- Countries
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- Iceland
- Norway
- Denmark
- Sweden
- Estonia
- Territory
- Reykajvik(Iceland), Bergen(Norway), Aarhus(Denmark), Gothenburg(Sweden), Uppsala(Sweden), Tartu(Estonia)
- Ethnic Origin
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- Health Status
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Recruitment
- Sources of recruitment
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- General population
- Participants from existing studies
- General Population
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- Volunteer enrolment
- Supplementary Information
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Between the years 1990 and 1994, a postal questionnaire was sent to 3000–4000 subjects at each center. Adults 20–44 years of age were randomly selected from seven centers in Northern Europe.
- Participants from Existing Studies
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- European Community Respiratory Health Survey, ECRHS
Number of Participants
- Number of Participants
- 21,802
- Number of Participants with Biological Samples
- Supplementary Information about selection criteria
Data Collection Events
| # | Name | Description | Start | End |
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| 0 |
RHINE - Baseline
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Questionnaires collected information about airways symptoms, smoking habits, indoor and outdoor environment, marital status, work, childhood and family, diseases, and general health. For the ... | 1990 | 1994 |
| 1 |
RHINE - Follow-up 1
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Questionnaires collected information about airways symptoms, smoking habits, indoor and outdoor environment, marital status, work, childhood and family, diseases, sleep related information and ... | 1999 | 2001 |
| 2 |
RHINE - Follow-up 2
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Questionnaires collected information about airways symptoms, smoking habits, indoor and outdoor environment, marital status, work, childhood and family, diseases, sleep related information and ... | 2010 | 2012 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
Socio-demographic and economic characteristics
Age/birthdate
Sex/gender
Marital/partner status
Family and household structure
Education
Residence
Labour force and retirement
Lifestyle and behaviours
Tobacco
Nutrition
Physical activity
Personal hygiene
Sleep
Other and unspecified lifestyle information
Birth, pregnancy and reproductive health history
Puberty, menstruation, menopause and andropause
Contraception
Pregnancy, delivery and birth
Diseases
Neoplasms (C00-D48)
Endocrine, nutritional and metabolic diseases (E00-E90)
Diseases of the nervous system (G00-G99)
Diseases of the ear and mastoid process (H60-H95)
Diseases of the circulatory system (I00-I99)
Diseases of the respiratory system (J00-J99)
Diseases of the digestive system (K00-K93)
Diseases of the skin and subcutaneous tissue (L00-L99)
Diseases without precise specification or falling into multiple categories
Symptoms and signs
Symptoms and signs involving the circulatory and respiratory systems (R00-R09)
Symptoms and signs involving the digestive system and abdomen (R10-R19)
General symptoms and signs (R50-R69)
Medication and supplements
Medication and supplement intake
Non-pharmacological interventions
Surgical interventions
Other and unspecified non-pharmacological interventions
Health and community care services utilization
Hospitalizations
Physical measures and assessments
Physical characteristics
Anthropometry
Physical environment
Housing characteristics
Chemical exposure
Biological exposure
Other physical environment characteristics
Administrative information
Identifiers
Date and time-related information
Data and sample collection center-related information