The PREVENT-COVID in Seniors Study: PRospEctiVe EvaluatioN of immuniTy after COVID-19 vaccines in Seniors
Networks
-
Datasets
-
Variables
-
The objective of this study is to characterize and compare both short- and long-term immune responses to the different COVID-19 vaccines, including among older adults and seniors.
The specific objectives are to:
* Describe the antibody levels and function of antibodies made after vaccination with each of the four COVID-19 vaccines and compared to a younger population;
* Compare antibody quantity and function after 1 or 2 doses of different COVID-19 vaccines, particularly in priority groups;
* Define the specificity and quality of T cell responses after 1 or 2 doses of different COVID-19 vaccines;
* Understand how previous coronavirus infection (with SARS-CoV-2 and hCoVs) impacts the antibody response made to COVID-19 vaccines; and
* Determine how protective the COVID-19 vaccines are, by detecting antibodies specific for SARS-CoV-2 Nucleocapsid protein after vaccination and by linking antibody response data to SARS-CoV-2 infection status throughout the study period.
- Start Year
- 2020
- Supplementary Information
-
Li FF, Liu A, Gibbs E, Tanunliong G, et al. A novel multiplex electrochemiluminescent immunoassay for detection and quantification of anti-SARS-CoV-2 IgG and anti-seasonal endemic human coronavirus IgG. Journal of Clinical Virology. 2022;146:105050. doi: 10.1016/j.jcv.2021.105050. PMID: 34883405
https://www.medrxiv.org/content/10.1101/2021.07.29.21261156v1
Visit PREVENT-COVID19
| Investigators | Contacts |
|---|---|
|
|
Design
- Study design
- Cohort
- Follow Up
- Participants are followed-up to 9 times at regular intervals.
Recruitment
- Recruitment Target
-
- Individuals
Number of Participants
- Number of Participants
- 1,000
- Number of Participants with Biological Samples
- 1,000
- Supplementary Information
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Timeline
Populations
The population is composed of 19 years old and older individuals residing in British Columbia and who are or will be receiving the first or the second dose of BNT162b2 COVID-19 vaccine.
Selection Criteria
- Minimum age
-
19
- Newborns
- Twins
- Countries
-
- Canada
- Territory
- Ethnic Origin
-
- Health Status
-
- Other Criteria
Recruitment
- Sources of recruitment
-
- General population
- General Population
-
- Volunteer enrolment
- Supplementary Information
-
Participants are recruited through the study website.
Number of Participants
- Number of Participants
- Number of Participants with Biological Samples
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
PREVENT-COVID19 - BNT162b2 - Baseline
|
Information about basic demographics and health were collected through a short online questionnaire before vaccination or before the second dose. Blood samples were collected by a dried blood ... | 2020-12 | |
| 2 |
PREVENT-COVID19 - BNT162b2 - Follow-up 1
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2021-02 | |
| 3 |
PREVENT-COVID19 - BNT162b2 - Follow-up 2
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2021-04 | |
| 4 |
PREVENT-COVID19 - BNT162b2 - Follow-up 3
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2021-06 | |
| 5 |
PREVENT-COVID19 - BNT162b2 - Follow-up 4
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2021-09 | |
| 6 |
PREVENT-COVID19 - BNT162b2 - Follow-up 5
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2021-11 | |
| 7 |
PREVENT-COVID19 - BNT162b2 - Follow-up 6
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2022-01 | |
| 8 |
PREVENT-COVID19 - BNT162b2 - Follow-up 7
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2022-03 | |
| 8 |
PREVENT-COVID19 - BNT162b2 - Follow-up 8
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2022-05 | |
| 9 |
PREVENT-COVID19 - BNT162b2 - Follow-up 9
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2022-07 |
The population is composed of 19 years old and older individuals residing in British Columbia and who are or will be receiving the first or the second dose of mRNA-1273 COVID-19 vaccine.
Selection Criteria
- Minimum age
-
19
- Newborns
- Twins
- Countries
-
- Canada
- Territory
- Ethnic Origin
-
- Health Status
-
- Other Criteria
Recruitment
- Sources of recruitment
-
- General population
- General Population
-
- Volunteer enrolment
- Supplementary Information
-
Participants are recruited through the study website.
Number of Participants
- Number of Participants
- Number of Participants with Biological Samples
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
PREVENT-COVID19 - mRNA-1273 - Baseline
|
Information about basic demographics and health were collected through a short online questionnaire before vaccination or before the second dose. Blood samples were collected by a dried blood ... | 2020-12 | |
| 1 |
PREVENT-COVID19 - mRNA-1273 - Follow-up 1
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2021-02 | |
| 2 |
PREVENT-COVID19 - mRNA-1273 - Follow-up 2
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2021-04 | |
| 3 |
PREVENT-COVID19 - mRNA-1273 - Follow-up 3
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2021-06 | |
| 4 |
PREVENT-COVID19 - mRNA-1273 - Follow-up 4
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2021-09 | |
| 5 |
PREVENT-COVID19 - mRNA-1273 - Follow-up 5
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2021-11 | |
| 6 |
PREVENT-COVID19 - mRNA-1273 - Follow-up 6
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2022-01 | |
| 7 |
PREVENT-COVID19 - mRNA-1273 - Follow-up 7
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2022-03 | |
| 8 |
PREVENT-COVID19 - mRNA-1273 - Follow-up 8
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2022-05 | |
| 9 |
PREVENT-COVID19 - mRNA-1273 - Follow-up 9
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2022-07 |
The population is composed of 19 years old and older individuals residing in British Columbia and who are or will be receiving the first or the second dose of ChAdOx1-S COVID-19 vaccine.
Selection Criteria
- Minimum age
-
19
- Newborns
- Twins
- Countries
-
- Canada
- Territory
- Ethnic Origin
-
- Health Status
-
- Other Criteria
Recruitment
- Sources of recruitment
-
- General population
- General Population
-
- Volunteer enrolment
- Supplementary Information
-
Participants are recruited through the study website.
Number of Participants
- Number of Participants
- Number of Participants with Biological Samples
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
PREVENT-COVID19 - ChAdOx1-S - Baseline
|
Information about basic demographics and health were collected through a short online questionnaire before vaccination or before the second dose. Blood samples were collected by a dried blood ... | 2020-12 | |
| 1 |
PREVENT-COVID19 - ChAdOx1-S - Follow-up 1
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2021-02 | |
| 2 |
PREVENT-COVID19 - ChAdOx1-S - Follow-up 2
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2021-04 | |
| 3 |
PREVENT-COVID19 - ChAdOx1-S - Follow-up 3
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2021-06 | |
| 4 |
PREVENT-COVID19 - ChAdOx1-S - Follow-up 4
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2021-09 | |
| 5 |
PREVENT-COVID19 - ChAdOx1-S - Follow-up 5
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2021-11 | |
| 6 |
PREVENT-COVID19 - ChAdOx1-S - Follow-up 6
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2022-01 | |
| 7 |
PREVENT-COVID19 - ChAdOx1-S - Follow-up 7
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2022-03 | |
| 8 |
PREVENT-COVID19 - ChAdOx1-S - Follow-up 8
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2022-05 | |
| 9 |
PREVENT-COVID19 - ChAdOx1-S - Follow-up 9
|
Blood samples were collected by a dried blood spot test or venipuncture. | 2022-07 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
Socio-demographic and economic characteristics
Age/birthdate
Sex/gender
Ethnicity, race and religion
Perception of health, quality of life, development and functional limitations
Perception of health
Diseases
Certain infectious and parasitic diseases (A00-B99)
Diseases of the respiratory system (J00-J99)
Diseases without precise specification or falling into multiple categories
Medication and supplements
Medication and supplement intake
Physical measures and assessments
Anthropometry
Laboratory measures
Virology
Administrative information
Identifiers
Date and time-related information
Questionnaire and interview-related information
Physical and cognitive measure and biosample-related information
Data and sample collection center-related information
Other administrative information