Prenatal Determinants of Inflammation - mediated Conditions Transdisciplinary Research
- Start Year
- 2010
- Supplementary Information
Visit PreDICTR
| Investigators | Contacts |
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Design
- Study design
- Cohort
- Follow Up
-
Phase 1: The mothers of the Pre-Conception cohort were followed-up within four weeks of conception, and in trimesters two and three.
The mothers of the Conception cohort were followed-up at each trimester.
The mothers of the High Risk Birth cohort were followed-up in their last trimester.
The children were followed-up at 6, 12 and 18 months of age.Phase 2: Phase 2 (2017) is designed to develop a panel of clinical and biomarker attributes that can predict and detect intra-uterine inflammation. Phase 2 will enroll only women in their first trimester and are deeded to have a pregnancy at high risk for inflammation (history of previous spontaneous abortions or premature deliveries, hypertension, obesity, associated inflammatory and/or autoimmune disease). Mothers will be assessed at enrollment and at labor and the offspring assessed at birth and at age 6 months.
- Supplementary Information
- Pregnant women and the offspring of the current pregnancy were recruited in the study.
Recruitment
- Recruitment Target
-
- Families
Number of Participants
- Number of Participants
- 70
- Number of Participants with Biological Samples
- 70
- Supplementary Information
-
Mothers(4 sub-groups): 35 participants
Children: 35 participants
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Availability of access information
By contacting the study representative
Timeline
Populations
Selection Criteria
- Sex
-
Women
- Newborns
- Twins
- Countries
-
- Canada
- Territory
- Saskatoon Health Region
- Ethnic Origin
-
- Health Status
-
- Other Criteria
- Women who intended to become pregnant within one year and became pregnant, had not used IVF (In-Vitro Fertilization treatment) and had not had a multiple-conceptus pregnancy.
Recruitment
- Sources of recruitment
-
- General population
- Specific population
- General Population
-
- Volunteer enrolment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Prospective participants were made aware of the study by their primary care physician or obstetrician or through publicly-accessible notices (such as prenatal classes and media announcements).
Number of Participants
- Number of Participants
- 15
- Number of Participants with Biological Samples
- 15
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
PreDICTR - Mothers - Pre-Conception - Before conception
|
Before conception, women answered questionnaires about demographic profile, social and physical environment (demographic characteristics of parents, family structure and composition, social ... |
2010 | 2013 |
| 1 |
PreDICTR - Mothers - Pre-Conception - First trimester of pregnancy
|
At first trimester of pregnancy, women answered questionnaires about demographic profile, social and physical environment (demographic characteristics of parents, family structure and ... |
2010 | 2013 |
| 2 |
PreDICTR - Mothers - Pre-Conception - Second trimester of pregnancy
|
At second trimester of pregnancy, women answered questionnaires about social and physical environment (demographic characteristics of parents, family structure and composition, social policy, ... |
2010 | 2013 |
| 3 |
PreDICTR - Mothers - Pre-Conception - Third trimester of pregnancy/birth
|
At third trimester of pregnancy and birth, women answered questionnaires about social and physical environment (demographic characteristics of parents, family structure and composition, social ... |
2010 | 2013 |
Selection Criteria
- Sex
-
Women
- Pregnant Women
-
- Third trimester
- Newborns
- Twins
- Countries
-
- Canada
- Territory
- Saskatoon Health Region
- Ethnic Origin
-
- Health Status
-
- Other Criteria
- Women who had a high risk pregnancy, had to not have used IVF (In-Vitro Fertilization treatment) and had not had a multiple-conceptus pregnancy.
Recruitment
- Sources of recruitment
-
- General population
- Specific population
- General Population
-
- Volunteer enrolment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Prospective participants were made aware of the study by their primary care physician or obstetrician or through publicly-accessible notices (such as pre-natal classes and media announcements).
Number of Participants
- Number of Participants
- 6
- Number of Participants with Biological Samples
- 6
Data Collection Event
At third trimester and birth, women answered questionnaires about demographic profile, social and physical environment (demographic characteristics of parents, family structure and composition, socio-economic status, neighbourhood characteristics, social support, non-parental child care, parental behaviour and lifestyle). They were assessed about medication history, birth history (gestation, labor, delivery and route), neonatal history, and their high risk condition (diabetes, obesity, high blood pressure, history of infections, history of premature labor/delivery or indication of premature labor/delivery or underlying medical conditions).
Weight, height, waist circumference and blood pressure were measured. A physical exam was performed. Body mass index was calculated.
Blood, hair, saliva, cord blood, umbilical cord and placenta were collected.
- Start Date
-
2010
- End Date
-
2013
- Data sources
-
- Questionnaires
- Physical measures
- Biosamples
- Data sources - Biosamples
-
- Blood
- Saliva
- Hair
- Cord blood
- Other : Umbilical cord and placenta.
Selection Criteria
- Sex
-
Women
- Pregnant Women
-
- First trimester
- Newborns
- Twins
- Countries
-
- Canada
- Territory
- Saskatoon Health Region
- Ethnic Origin
-
- Health Status
-
- Other Criteria
- Women had to be at first trimester of pregnancy, had to not have used IVF (In-Vitro Fertilization treatment) and had not had a multiple-conceptus pregnancy.
Recruitment
- Sources of recruitment
-
- General population
- Specific population
- General Population
-
- Volunteer enrolment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Prospective participants were made aware of the study by their primary care physician or obstetrician or through publicly-accessible notices (such as pre-natal classes and media announcements).
Number of Participants
- Number of Participants
- 14
- Number of Participants with Biological Samples
- 14
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
PreDICTR - Mothers - Conception - First trimester of pregnancy
|
At first trimester of pregnancy, women answered questionnaires about demographic profile, social and physical environment (demographic characteristics of parents, family structure and ... |
2010 | 2018 |
| 1 |
PreDICTR - Mothers - Conception - Second trimester of pregnancy
|
At second trimester of pregnancy, women answered questionnaires about social and physical environment (demographic characteristics of parents, family structure and composition, social policy, ... |
2010 | 2018 |
| 2 |
PreDICTR - Mothers - Conception - Third trimester of pregnancy/birth
|
At third trimester of pregnancy and birth, women answered questionnaires about social and physical environment (demographic characteristics of parents, family structure and composition, social ... |
2010 | 2018 |
Selection Criteria
- Newborns
- Twins
- Countries
-
- Canada
- Territory
- Saskatoon
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
-
- Other specific population : Children of the women (from the Pre-Conception, Conception and High Risk Birth cohorts) participating in the study.
Number of Participants
- Number of Participants
- 35
- Number of Participants with Biological Samples
- 35
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
PreDICTR - Children - Birth
|
At birth, the newborn status was established. A physical exam and APGAR test were performed. Meconium and urine were also collected. |
2010 | 2018 |
| 1 |
PreDICTR - Children - 6 months old
|
The mothers answered questionnaires about medical, family, social and environmental histories of their offspring as well as completed a medication and infection diary. Children were assessed ... |
2010 | 2018 |
| 2 |
PreDICTR - Children - 12 months old
|
The mothers answered questionnaires about medical, family, social and environmental histories of their offspring as well as completed a medication and infection diary. Children were assessed ... |
2011 | 2019 |
| 3 |
PreDICTR - Children - 18 months old
|
The mothers answered questionnaires about medical, family, social and environmental histories of their offspring as well as completed a medication and infection diary. Children were assessed ... |
2011 | 2019 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
- Cognitive functioning
- Personality
- Psychological distress and emotions
- Other psychological measures and assessments
- Life events
- Beliefs and values
- Perception of health
- Quality of life
- Life course development
- Functional limitations
- Other perception of health, quality of life and functional limitation-related information
- Tobacco
- Alcohol
- Drugs
- Nutrition
- Breastfeeding
- Physical activity
- Sleep
- Sexual behaviours and orientation
- Technological devices
- Misbehaviour and criminality
- Other and unspecified lifestyle information
Socio-demographic and economic characteristics
Lifestyle and behaviours
Birth, pregnancy and reproductive health history
Perception of health, quality of life, development and functional limitations
Diseases
Symptoms and signs
Medication and supplements
Non-pharmacological interventions
Health and community care services utilization
Physical measures and assessments
Laboratory measures
Cognition, personality and psychological measures and assessments
Life events, life plans, beliefs and values
Preschool, school and work life
Physical environment
Administrative information
Personality
Psychological distress and emotions
Life events
Quality of life
Life course development
Functional limitations
Nutrition