Maelstrom Research Staging

Pre-Eclampsia New Emerging Team

Networks -

Datasets -

Variables -

Start Year: 2003
End Year: 2010

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Investigators	Contacts
Dr. Graeme N. Smith Queen's University Graeme N. Smith Title Dr. Name Graeme N. Smith Email gns@queensu.ca Phone 613-548-2405 Institution Queen's University Department Obstetrics and Gynaecology Address Victory 4 Kingston Canada Dr. Mark Walker Ottawa Hospital Research Institute / University of Ottawa Mark Walker Title Dr. Name Mark Walker Email mwalke6@uottawa.ca Phone +1 613 562 5800 X 7800 Institution Ottawa Hospital Research Institute / University of Ottawa Address 75 Laurier Ave. E Ottawa Canada Dr. Aizhong Liu Central South University Aizhong Liu Title Dr. Name Aizhong Liu Institution Central South University Department Department of Epidemiology and Biostatistics Address Changsha China Dr. Shi Wu Wen Ottawa Hospital Research Institute / University of Ottawa Shi Wu Wen Title Dr. Name Shi Wu Wen Email swwen@ohri.ca Phone (613)737-8899 ext.73912 Institution Ottawa Hospital Research Institute / University of Ottawa Department Department of Obstetrics and Gynecology Address 501 Smyth Road, Box 241 Ottawa Canada Dr. Michelle Hladunewich University of Toronto, Sunnybrook Health Sciences Centre Michelle Hladunewich Title Dr. Name Michelle Hladunewich Phone +1 416 480 5590 Institution University of Toronto, Sunnybrook Health Sciences Centre Department Department of Nephrology Address Toronto Canada	Dr. Graeme N. Smith Queen's University Graeme N. Smith Title Dr. Name Graeme N. Smith Email gns@queensu.ca Phone 613-548-2405 Institution Queen's University Department Obstetrics and Gynaecology Address Victory 4 Kingston Canada

Investigators

Contacts

Dr. Graeme N. Smith
Queen's University

Graeme N. Smith

Title

Dr.

Name

Graeme N. Smith

Email

gns@queensu.ca

Phone

613-548-2405

Institution

Queen's University

Department

Obstetrics and Gynaecology

Address

Victory 4 Kingston Canada
Dr. Mark Walker
Ottawa Hospital Research Institute / University of Ottawa

Mark Walker

Title

Dr.

Name

Mark Walker

Email

mwalke6@uottawa.ca

Phone

+1 613 562 5800 X 7800

Institution

Ottawa Hospital Research Institute / University of Ottawa

Address

75 Laurier Ave. E Ottawa Canada
Dr. Aizhong Liu
Central South University

Aizhong Liu

Title

Dr.

Name

Aizhong Liu

Institution

Central South University

Department

Department of Epidemiology and Biostatistics

Address

Changsha China
Dr. Shi Wu Wen
Ottawa Hospital Research Institute / University of Ottawa

Shi Wu Wen

Title

Dr.

Name

Shi Wu Wen

Email

swwen@ohri.ca

Phone

(613)737-8899 ext.73912

Institution

Ottawa Hospital Research Institute / University of Ottawa

Department

Department of Obstetrics and Gynecology

Address

501 Smyth Road, Box 241 Ottawa Canada
Dr. Michelle Hladunewich
University of Toronto, Sunnybrook Health Sciences Centre

Michelle Hladunewich

Title

Dr.

Name

Michelle Hladunewich

Phone

+1 416 480 5590

Institution

University of Toronto, Sunnybrook Health Sciences Centre

Department

Department of Nephrology

Address

Toronto Canada

Dr. Graeme N. Smith
Queen's University

Graeme N. Smith

Title

Dr.

Name

Graeme N. Smith

Email

gns@queensu.ca

Phone

613-548-2405

Institution

Queen's University

Department

Obstetrics and Gynaecology

Address

Victory 4 Kingston Canada

Design

Study design: Cohort
Follow Up: Participants were followed up for 5 years. Children were followed yearly until age 5 and mothers were followed up 1, 3 and 5 years postpartum.
Supplementary Information

Marker Paper

Smith G.N., Walker M.C, Liu A., Wen S.W., Swansburg M., Ramshaw H., White R.R., Roddy M., Hladunewich M.; Pre-Eclampsia New Emerging Team (PE-NET).2008. A history of preeclampsia identifies women who have underlying cardiovascular risk factors.American Journal of Obstetrics & Gynecology;200(1):58.

PUBMED 18691690

Recruitment

Recruitment Target

Families

Number of Participants

Number of Participants: 470
Number of Participants with Biological Samples: 470
Supplementary Information: Mothers: 235 participants
Children: 235 participants

Access

Availability of data and biosamples

Possible Access to Data
Possible Access to Biosamples
Other

Availability of access information

By contacting the study representative

Sector of research

	Possible Access to Data	Possible Access to Biosamples
Investigators from the public sector
Investigators from the private sector
Investigators from not-for-profit organization

Transfer

	Possible Access to Data	Possible Access to Biosamples
Can leave the study facility
Can leave the country

All data to be anonymized and encrypted. All samples to be anonymized. All conditions and restrictions are dependent on each given projects ethics board approval.

Cost

Possible Access to Data	Not yet defined
Possible Access to Biosamples	Not yet defined

Cost reduction for co-analyses

Possible Access to Data
Possible Access to Biosamples

Cost reductions to be considered on a case-by-case basis at the discretion of the primary investigators.

Yes

Not applicable

Don't know

Timeline

Populations

Selection Criteria

Sex

Women

Pregnant Women

Second trimester
Third trimester

Newborns

Twins

Countries

Canada

Territory

Ethnic Origin

Health Status

Other Criteria

Women with a history of hypertension, diabetes (including development of gestational diabetes in any pregnancy), renal disease, or cardiovascular disease and if they lived beyond a 50 km radius from either the Kingston or Ottawa General Hospitals were excluded.

Supplementary Information about selection criteria

Recruitment

Sources of recruitment

Specific population

Specific Population

Clinic patients

Supplementary Information

All women diagnosed with pre-eclampsia at the time of presentation to clinic or admission/transfer to either the Kingston or Ottawa General Hospitals were approached to participate.

Number of Participants

Number of Participants: 95
Number of Participants with Biological Samples: 95
Supplementary Information about selection criteria: Baseline: 95 participants
1 year postpartum: 66 participants
3 year postpartum: 43 participants
5 year postpartum: 17 participants

Data Collection Events

#	Name	Description	Start	End
0	PE-NET - Pre-eclampsia Mothers - Baseline PE-NET - Pre-eclampsia Mothers - Baseline Start Date 2003-09 End Date 2009-10 Data sources Questionnaires Physical measures Files No files could be found.	Demographic information was collected such as age, race, education, household income, parity, family medical history, previous pregnancies with pre-eclampsia, and index pregnancy complicated ...	2003-09	2009-10
1	PE-NET - Pre-eclampsia Mothers - Birth PE-NET - Pre-eclampsia Mothers - Birth Start Date 2004-01 End Date 2010-01 Data sources Questionnaires Biosamples Data sources - Biosamples Blood Tissues : Placenta Files No files could be found.	Information was collected about pregnancy complications, mode of delivery, severe maternal morbidity and maternal mental health. Maternal blood and placenta were collected as well.	2004-01	2010-01
2	PE-NET - Pre-eclampsia Mothers - 1 year postpartum PE-NET - Pre-eclampsia Mothers - 1 year postpartum Start Date 2005-01 End Date 2010-01 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Urine Saliva Files No files could be found.	Information about race,education level, household income, use of antihypertensive medication and smoking was collected. Anthropometric measurements were taken and calculated for each ...	2005-01	2010-01
3	PE-NET - Pre-eclampsia Mothers - 3 years postpartum PE-NET - Pre-eclampsia Mothers - 3 years postpartum Start Date 2007-01 End Date 2010-01 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	Information about race,education level, household income, use of antihypertensive medication and smoking was collected. BMI, systolic and diastolic blood pressure were measured. ...	2007-01	2010-01
4	PE-NET - Pre-eclampsia Mothers - 5 years postpartum PE-NET - Pre-eclampsia Mothers - 5 years postpartum Start Date 2009-01 End Date 2010-01 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	Information about race,education level, household income, use of antihypertensive medication and smoking was collected. BMI, systolic and diastolic blood pressure were measured. ...	2009-01	2010-01

Selection Criteria

Sex

Women

Pregnant Women

Second trimester
Third trimester

Newborns

Twins

Countries

Canada

Territory

Ethnic Origin

Health Status

Other Criteria

Supplementary Information about selection criteria

Recruitment

Sources of recruitment

Specific population

Specific Population

Clinic patients

Supplementary Information

After each pre-eclampsia subject was recruited, the next normotensive women who matched by parity, maternal age, and race identified in the antenatal clinics or on labor and delivery were approached to participate.

Number of Participants

Number of Participants: 140
Number of Participants with Biological Samples: 140
Supplementary Information about selection criteria: Baseline: 140 participants
1 year postpartum: 121 participants
3 year postpartum: 62 participants
5 year postpartum: 16 participants

Data Collection Events

#	Name	Description	Start	End
0	PE-NET - Normotensive Mothers - Baseline PE-NET - Normotensive Mothers - Baseline Start Date 2003-09 End Date 2009-10 Data sources Questionnaires Physical measures Files No files could be found.	Demographic information was collected such as age, race, education, household income, parity, family medical history, previous pregnancies with pre-eclampsia, and index pregnancy complicated ...	2003-09	2009-10
1	PE-NET - Normotensive Mothers - Birth PE-NET - Normotensive Mothers - Birth Start Date 2004-01 End Date 2010-01 Data sources Questionnaires Biosamples Data sources - Biosamples Blood Tissues : Placenta Files No files could be found.	Information was collected about pregnancy complications, mode of delivery, severe maternal morbidity and maternal mental health. Maternal blood and placenta were collected as well.	2004-01	2010-01
2	PE-NET - Normotensive Mothers - 1 year postpartum PE-NET - Normotensive Mothers - 1 year postpartum Start Date 2005-01 End Date 2010-01 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Urine Saliva Files No files could be found.	Information about race,education level, household income, use of antihypertensive medication and smoking was collected. Anthropometric measurements were taken and calculated for each ...	2005-01	2010-01
3	PE-NET - Normotensive Mothers - 3 years postpartum PE-NET - Normotensive Mothers - 3 years postpartum Start Date 2007-01 End Date 2010-01 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	Information about race,education level, household income, use of antihypertensive medication and smoking was collected. BMI, systolic and diastolic blood pressure were measured. ...	2007-01	2010-01
4	PE-NET - Normotensive Mothers - 5 years postpartum PE-NET - Normotensive Mothers - 5 years postpartum Start Date 2009-01 End Date 2010-01 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	Information about race,education level, household income, use of antihypertensive medication and smoking was collected. BMI, systolic and diastolic blood pressure were measured. ...	2009-01	2010-01

Selection Criteria

Newborns

Twins

Countries

Canada

Territory

Ethnic Origin

Health Status

Recruitment

Sources of recruitment

Specific population

Specific Population

Other specific population : Children of participating mothers

Number of Participants

Number of Participants: 95
Number of Participants with Biological Samples: 95
Supplementary Information about selection criteria: Baseline: 95 participants
1 year postpartum: 66 participants
3 year postpartum: 43 participants
5 year postpartum: 17 participants

Data Collection Events

#	Name	Description	Start	End
0	PE-NET - Pre-eclampsia Children - Birth PE-NET - Pre-eclampsia Children - Birth Start Date 2004-01 End Date 2010-01 Data sources Questionnaires Physical measures Files No files could be found.	Information about the sex, gestational age at birth, placental weight, magnesium sulphate usage, APGAR score, admission information was collected.	2004-01	2010-01
1	PE-NET - Pre-eclampsia Children - 1 year postpartum PE-NET - Pre-eclampsia Children - 1 year postpartum Start Date 2005-01 End Date 2010-01 Data sources Questionnaires Cognitive measures Biosamples Data sources - Biosamples Saliva Files No files could be found.	Neurodevelopment was assessed via the Ages and Stages Questionnaire (ASQ). Information such as gross motor, fine motor, communication, personal social and problem-solving skills were measured. ...	2005-01	2010-01
2	PE-NET - Pre-eclampsia Children - 2 year postpartum PE-NET - Pre-eclampsia Children - 2 year postpartum Start Date 2006-01 End Date 2010-01 Data sources Questionnaires Files No files could be found.	Neurodevelopment was assessed via the Ages and Stages Questionnaire (ASQ) which was mailed out to the participant.	2006-01	2010-01
3	PE-NET - Pre-eclampsia Children - 3 year postpartum PE-NET - Pre-eclampsia Children - 3 year postpartum Start Date 2007-01 End Date 2010-01 Data sources Questionnaires Cognitive measures Biosamples Data sources - Biosamples Hair Files No files could be found.	Neurodevelopment was assessed via the Ages and Stages Questionnaire (ASQ). Information such as gross motor, fine motor, communication, personal social and problem-solving skills were measured. ...	2007-01	2010-01
4	PE-NET - Pre-eclampsia Children - 4 year postpartum PE-NET - Pre-eclampsia Children - 4 year postpartum Start Date 2008-01 End Date 2010-01 Data sources Questionnaires Files No files could be found.	Neurodevelopment was assessed via the Ages and Stages Questionnaire (ASQ) which was mailed out to the participant.	2008-01	2010-01
5	PE-NET - Pre-eclampsia Children - 5 year postpartum PE-NET - Pre-eclampsia Children - 5 year postpartum Start Date 2009-01 End Date 2010-01 Data sources Questionnaires Cognitive measures Biosamples Data sources - Biosamples Hair Files No files could be found.	Neurodevelopment was assessed via the Ages and Stages Questionnaire (ASQ). Information such as gross motor, fine motor, communication, personal social and problem-solving skills were ...	2009-01	2010-01

Selection Criteria

Newborns

Twins

Countries

Canada

Territory

Ethnic Origin

Health Status

Recruitment

Sources of recruitment

Specific population

Specific Population

Other specific population : Children of participating mothers

Number of Participants

Number of Participants: 140
Number of Participants with Biological Samples: 140
Supplementary Information about selection criteria: Baseline: 140 participants
1 year postpartum: 121 participants
3 year postpartum: 62 participants
5 year postpartum: 16 participants

Data Collection Events

#	Name	Description	Start	End
0	PE-NET - Normotensive Children - Birth PE-NET - Normotensive Children - Birth Start Date 2004-01 End Date 2010-01 Data sources Questionnaires Physical measures Files No files could be found.	Information about the sex, gestational age at birth, placental weight, magnesium sulphate usage, APGAR score, admission information was collected.	2004-01	2010-01
1	PE-NET - Normotensive Children - 1 year postpartum PE-NET - Normotensive Children - 1 year postpartum Start Date 2005-01 End Date 2010-01 Data sources Questionnaires Cognitive measures Biosamples Data sources - Biosamples Saliva Files No files could be found.	Neurodevelopment was assessed via the Ages and Stages Questionnaire (ASQ). Information such as gross motor, fine motor, communication, personal social and problem-solving skills were measured. ...	2005-01	2010-01
2	PE-NET - Normotensive Children - 2 year postpartum PE-NET - Normotensive Children - 2 year postpartum Start Date 2006-01 End Date 2010-01 Data sources Questionnaires Files No files could be found.	Neurodevelopment was assessed via the Ages and Stages Questionnaire (ASQ) which was mailed out to the participant.	2006-01	2010-01
3	PE-NET - Normotensive Children - 3 year postpartum PE-NET - Normotensive Children - 3 year postpartum Start Date 2007-01 End Date 2010-01 Data sources Questionnaires Cognitive measures Biosamples Data sources - Biosamples Hair Files No files could be found.	Neurodevelopment was assessed via the Ages and Stages Questionnaire (ASQ). Information such as gross motor, fine motor, communication, personal social and problem-solving skills were measured. ...	2007-01	2010-01
4	PE-NET - Normotensive Children - 4 year postpartum PE-NET - Normotensive Children - 4 year postpartum Start Date 2008-01 End Date 2010-01 Data sources Questionnaires Files No files could be found.	Neurodevelopment was assessed via the Ages and Stages Questionnaire (ASQ) which was mailed out to the participant.	2008-01	2010-01
5	PE-NET - Normotensive Children - 5 year postpartum PE-NET - Normotensive Children - 5 year postpartum Start Date 2009-01 End Date 2010-01 Data sources Questionnaires Cognitive measures Biosamples Data sources - Biosamples Hair Files No files could be found.	Neurodevelopment was assessed via the Ages and Stages Questionnaire (ASQ). Information such as gross motor, fine motor, communication, personal social and problem-solving skills were measured. ...	2009-01	2010-01

Classifications

Socio-demographic and economic characteristics
Lifestyle and behaviours
Birth, pregnancy and reproductive health history
Perception of health, quality of life, development and functional limitations
Diseases
Symptoms and signs
Medication and supplements
Non-pharmacological interventions
Health and community care services utilization
Death
Physical measures and assessments
Laboratory measures
Cognition, personality and psychological measures and assessments
Life events, life plans, beliefs and values
Preschool, school and work life
Social environment and relationships
Physical environment
Administrative information

Socio-demographic and economic characteristics

Age/birthdate

Sex/gender

Education

Residence

Ethnicity, race and religion

Income, possessions, and benefits

Lifestyle and behaviours

Tobacco

Nutrition

Breastfeeding

Birth, pregnancy and reproductive health history

Pregnancy, delivery and birth

Diseases

Endocrine, nutritional and metabolic diseases (E00-E90)

Diseases of the circulatory system (I00-I99)

Pregnancy, childbirth and the puerperium (O00-O9A)

Certain conditions originating in the perinatal period (P00-P96)

Diseases without precise specification or falling into multiple categories

Medication and supplements

Medication and supplement intake

Posology and protocol of administration

Non-pharmacological interventions

Surgical interventions

Radiological interventions

Laboratory diagnosis interventions

Other and unspecified non-pharmacological interventions

Health and community care services utilization

Hospitalizations

Physical measures and assessments

Anthropometry

Circulation and respiration

Skin and subcutaneous tissue

Other physical measures and assessments

Laboratory measures

Biochemistry

Histology

Other laboratory measures

Administrative information

Identifiers

Date and time-related information

Questionnaire and interview-related information

Physical and cognitive measure and biosample-related information

Data and sample collection center-related information

Other administrative information

Individual Study / PE-NET

Pre-Eclampsia New Emerging Team

Members

Design

Marker Paper

Recruitment

Number of Participants

Access

Timeline

Populations

Selection Criteria

Recruitment

Number of Participants

Files

Data Collection Events

Selection Criteria

Recruitment

Number of Participants

Files

Data Collection Events

Selection Criteria

Recruitment

Number of Participants

Files

Data Collection Events

Selection Criteria

Recruitment

Number of Participants

Files

Data Collection Events

Files

Classifications

Variables Classifications

Individual Study / PE-NET

Pre-Eclampsia New Emerging Team

Members

Graeme N. Smith

Mark Walker

Aizhong Liu

Shi Wu Wen

Michelle Hladunewich

Graeme N. Smith

Design

Marker Paper

Recruitment

Number of Participants

Access

Representative

Timeline

Populations

Selection Criteria

Recruitment

Number of Participants

Files

Data Collection Events

PE-NET - Pre-eclampsia Mothers - Baseline

PE-NET - Pre-eclampsia Mothers - Birth

PE-NET - Pre-eclampsia Mothers - 1 year postpartum

PE-NET - Pre-eclampsia Mothers - 3 years postpartum

PE-NET - Pre-eclampsia Mothers - 5 years postpartum

Selection Criteria

Recruitment

Number of Participants

Files

Data Collection Events

PE-NET - Normotensive Mothers - Baseline

PE-NET - Normotensive Mothers - Birth

PE-NET - Normotensive Mothers - 1 year postpartum

PE-NET - Normotensive Mothers - 3 years postpartum

PE-NET - Normotensive Mothers - 5 years postpartum

Selection Criteria

Recruitment

Number of Participants

Files

Data Collection Events

PE-NET - Pre-eclampsia Children - Birth

PE-NET - Pre-eclampsia Children - 1 year postpartum

PE-NET - Pre-eclampsia Children - 2 year postpartum

PE-NET - Pre-eclampsia Children - 3 year postpartum

PE-NET - Pre-eclampsia Children - 4 year postpartum

PE-NET - Pre-eclampsia Children - 5 year postpartum

Selection Criteria

Recruitment

Number of Participants

Files

Data Collection Events

PE-NET - Normotensive Children - Birth

PE-NET - Normotensive Children - 1 year postpartum

PE-NET - Normotensive Children - 2 year postpartum

PE-NET - Normotensive Children - 3 year postpartum

PE-NET - Normotensive Children - 4 year postpartum

PE-NET - Normotensive Children - 5 year postpartum

Files

Classifications

Variables Classifications