Origin of Variances in the Oldest-Old: Octogenarian Twins
The study aimed to investigate the etiology of individual differences among twin-pairs age 80 and older, on a range of domains including health and functional capacity, cognitive functioning, psychological well-being, personality and personal control.
- Start Year
- 1991
- End Year
- 2002
Visit OCTO-Twin
| Investigators | Contacts |
|---|---|
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Design
- Study design
- Cohort
- Follow Up
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Participants were assessed up to 5 times at 2-year intervals providing up to 8 years of follow-up
- Supplementary Information
Marker Paper
[McClearn, G. E., Johansson, B., Berg, S., Pedersen, N. L., Ahern, F., Petrill, S. A., et al. (1997). Substantial genetic influence on cognitive abilities in twins 80 or more years old. Science, 276, 1560-1563.]
PUBMED 9171059
Recruitment
- Recruitment Target
-
- Families
Number of Participants
- Number of Participants
- 702
- Number of Participants with Biological Samples
- 552
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Timeline
OCTO-Twin - Population
Twin pairs were drawn from the Swedish population-based Twin Registry. At the first wave the twins had to be born 1913 or earlier and both partners in the pair had to accept participation. At the first wave 351 twin pairs (149 MZ and 202 like-sex DZ pairs) were investigated (average age 83.57 years; 67% of the sample were female). The two-year longitudinal follow-ups were conducted on all twins alive who agreed to participate, irrespective of twin status. The participation in the 2nd Wave was 235 pairs (568 individuals), in the 3rd wave 144 pairs (430 individuals), in the 4th wave 4 86 pairs (315 individuals), and at the last occasion (wave 5) 43 pairs (222 individuals participated. The initial OCTO-Twin sample was found to be similar to a representative sample of non-twins aged 80 and older (Simmons et al., 1997). Linkages are continuously performed to the Twin Registry/Census register and to the death register for vital status.
Selection Criteria
- Minimum age
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79
- Maximum age
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98
- Newborns
- Twins
- Countries
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- Sweden
- Territory
- Ethnic Origin
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- Health Status
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- Other Criteria
- Supplementary Information about selection criteria
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
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- Other specific population : The Swedish population-based Twin Registry
Number of Participants
- Number of Participants
- 702
- Number of Participants with Biological Samples
- 552
- Supplementary Information about selection criteria
-
351 twin pairs, including 149 identical or monozygotic (MZ) pairs, and 202 same-sex fraternal or dizygotic (DZ) twin pairs
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
OCTO-Twin - wave 1
|
Baseline |
1991-02 | 1994-03 |
| 1 |
OCTO-Twin - wave 2
|
First follow-up of participant. The number of tested individuals and pairs were 568 and 235 respectively. |
1993-05 | 1996-05 |
| 2 |
OCTO-Twin - wave 3
|
Second follow-up of participant. The number of tested individuals and pairs were 430 and 144 respectively. |
1995-04 | 1998-05 |
| 3 |
OCTO-Twin - wave 4
|
Third follow-up of participant. The number of tested individuals and pairs were 315 and 86 respectively. |
1997-04 | 2000-05 |
| 4 |
OCTO-Twin - wave 5
|
Fourth follow-up of participant. The number of tested individuals and pairs were 222 and 43 respectively. |
1999-12 | 2002-03 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
- Cognitive functioning
- Personality
- Psychological distress and emotions
- Other psychological measures and assessments
- Life events
- Beliefs and values
- Perception of health
- Quality of life
- Life course development
- Functional limitations
- Other perception of health, quality of life and functional limitation-related information
Socio-demographic and economic characteristics
Lifestyle and behaviours
Birth, pregnancy and reproductive health history
Perception of health, quality of life, development and functional limitations
Diseases
Symptoms and signs
Medication and supplements
Non-pharmacological interventions
Health and community care services utilization
Death
Physical measures and assessments
Cognition, personality and psychological measures and assessments
Life events, life plans, beliefs and values
Social environment and relationships
Administrative information
Cognitive functioning
Personality
Psychological distress and emotions
Beliefs and values
Quality of life
Functional limitations