Ottawa and Kingston Birth Cohort
- The purposes of the Ottawa and Kingston Birth Cohort were to:
- collect epidemiologic information and biological specimens prospectively to study exposures or risk factors and their association with adverse pregnancy outcomes;
- serve as a repository of maternal and infant genetic and epidemiologic information by creating the largest maternal and fetal/infant biobank in Canada for use by future investigators.
- Start Year
- 2002
- End Year
- 2009
- Supplementary Information
| Investigators | Contacts |
|---|---|
|
|
Design
- Study design
- Cohort
- Follow Up
- After recruitment, mothers were followed-up until birth.
- Supplementary Information
Marker Paper
Walker MC, Finkelstein S.A., Rennicks White R., Shachkins S., Smith G.N., Wen S.W., Rodger M. The Ottawa And Kingston (Oak) Birth Cohort: Development And Achievements. Journal of Obstetrics and gynaecology Canada 2011 Nov;33(11):1124-33.
PUBMED 22082786
Recruitment
- Recruitment Target
-
- Families
Number of Participants
- Number of Participants
- 10,260
- Number of Participants with Biological Samples
- 9,416
- Supplementary Information
-
Mothers: 8085 participants
Children: 2175 participants
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Availability of access information
By contacting the study representative
Sector of research
| Possible Access to Data | Possible Access to Biosamples | |
|---|---|---|
| Investigators from the public sector | ||
| Investigators from the private sector | ||
| Investigators from not-for-profit organization |
Restrictions on use of the data and samples, based upon existing REB approval and associated limitations. No genetic testing may be performed on the samples.
Transfer
| Possible Access to Data | Possible Access to Biosamples | |
|---|---|---|
| Can leave the study facility | ||
| Can leave the country |
Cost
| Possible Access to Data | Variable Cost |
| Possible Access to Biosamples | Variable Cost |
Fees are dependent on the amount of work required to prepare the data or samples, depending on which elements are being requested.
Cost reduction for co-analyses
| Possible Access to Data | |
| Possible Access to Biosamples |
Supplementary Information
Timeline
Populations
Selection Criteria
- Sex
-
Women
- Pregnant Women
-
- First trimester
- Second trimester
- Newborns
- Twins
- Countries
-
- Canada
- Territory
- Ottawa and Kingston
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- Specific population
- Participants from existing studies
- General Population
-
- Volunteer enrolment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Participants were recruited from the Ottawa Hospital and Kingston General Hospital during prenatal care or ultrasound visits. Posters and brochures in both official languages were also distributed to the offices of obstetricians and family physicians within the study catchment area.
- Participants from Existing Studies
-
- Folic Acid in Second Trimester study
- Thrombophilia and Intrauterine Growth REStriction Study
- Folic Acid Supplementation in Early Second Trimester and Risk of Pre-Eclampsia study
Number of Participants
- Number of Participants
- 8,085
- Number of Participants with Biological Samples
- 7,241
- Supplementary Information about selection criteria
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
OaK Birth Cohort - Mothers - Phase I
|
Data on biological and environmental variables potentially influencing adverse pregnancy outcomes were collected. Data concerning the mother's medical and obstetrical histories, health ... |
2002-10 | 2009-04 |
| 1 |
OaK Birth Cohort - Mothers - Phase II
|
Pregnancy outcomes and delivery data were abstracted from hospital charts upon delivery. A blood sample was taken. |
2003-02 | 2009-11 |
Selection Criteria
- Newborns
- Twins
- Countries
-
- Canada
- Territory
- Ottawa and Kingston
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
-
- Other specific population : Children of women already included in the study.
Number of Participants
- Number of Participants
- 2,175
- Number of Participants with Biological Samples
- 2,175
Data Collection Event
Infant data, such as sex, weight, and other variables indicative of neonatal health were collected at birth.
A cord blood sample was taken.
- Start Date
-
2003-02
- End Date
-
2009-11
- Data sources
-
- Biosamples
- Other : Medical records
- Data sources - Biosamples
-
- Cord blood
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
Socio-demographic and economic characteristics
Lifestyle and behaviours
Birth, pregnancy and reproductive health history
Diseases
Medication and supplements
Non-pharmacological interventions
Health and community care services utilization
Physical measures and assessments
Laboratory measures
Administrative information