Oxidative stress, fetal growth and programming of the metabolic syndrome and cardiovascular disorders
- Start Year
- 2006
- End Year
- 2008
Visit MIROS C
| Investigators | Contacts |
|---|---|
|
|
Design
- Study design
- Cohort
- Follow Up
- After the baseline visit during their second trimester of pregnancy, participants were followed-up during their third trimester of pregnancy, at birth, 3 months postpartum and 12 months postpartum.
- Supplementary Information
-
Mothers: 248 participants
Children: 248 participants
Marker Paper
Luo Zhong-Cheng, Bilodeau Jean-François, Nuyt Anne-Monique, Fraser William D., Julien Pierre, Audibert François, Xiao Lin, Garofalo Carole, Levy Emile. Perinatal Oxidative Stress May Affect Fetal Ghrelin Levels in Humans.Scientific Reports 2015; 5: 17881.
PUBMED 26643495
Recruitment
- Recruitment Target
-
- Families
Number of Participants
- Number of Participants
- 614
- Number of Participants with Biological Samples
- 562
- Supplementary Information
-
Mothers: 307 participants
Children: 307 participants
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Availability of access information
By contacting the study representative
Sector of research
| Possible Access to Data | Possible Access to Biosamples | |
|---|---|---|
| Investigators from the public sector | ||
| Investigators from the private sector | ||
| Investigators from not-for-profit organization |
Transfer
| Possible Access to Data | Possible Access to Biosamples | |
|---|---|---|
| Can leave the study facility | ||
| Can leave the country |
anonymization
Cost
| Possible Access to Data | Not yet defined |
| Possible Access to Biosamples | N/A |
Usually, open to collaboration
Cost reduction for co-analyses
| Possible Access to Data | |
| Possible Access to Biosamples |
Supplementary Information
Timeline
Populations
Selection Criteria
- Sex
-
Women
- Minimum age
-
18
- Maximum age
-
45
- Pregnant Women
-
- Second trimester
- Newborns
- Twins
- Countries
-
- Canada
- Territory
- Montreal, Quebec
- Ethnic Origin
-
- Health Status
-
- Supplementary Information about selection criteria
-
- Exclusion criteria:
- Women <18 years or >45 years of age;
- Women who are illegal drugs users;
- Women with multiple pregnancies (twin or more fetuses);
- Fetuses or infants with known congenital anomalies or chromosomal abnormalities (e.g. Down syndrome);
- Mothers or infants with endocrine disorders: growth hormone deficiency, hyperthyroidism, hypothyroidism, or other known endocrine disorders;
- Mothers or infants with severe illnesses or life threatening conditions: renal failure, active or chronic liver diseases, epilepsy, collagen diseases, serious pulmonary disease, serious hematologic disorders, cancers, heart disease, or other life threatening conditions;
- Fetal or infants deaths (only expected 0 or 1 case within the recruited sample).
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Women were recruited in three hospitals in Montreal: Saint-Justine Hospital, General Jewish Hospital and Saint Mary's Hospital.
Number of Participants
- Number of Participants
- 307
- Number of Participants with Biological Samples
- 307
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
MIROS C - Mothers - Second trimester
|
Data on demographic characteristics, family structure, socio-economic structure, nutrition and medication, parental health and physical environment were collected through ... |
2006-08 | 2008-12 |
| 1 |
MIROS C - Mothers - Third trimester
|
Data on demographic characteristics, family structure, socio-economic structure, nutrition and medication, parental health and physical environment were collected through ... |
2006-09 | 2009-01 |
| 2 |
MIROS C - Mothers - Birth
|
Data on demographic characteristics, family structure, socio-economic structure, nutrition and medication, parental health and physical environment were collected through ... |
2006-12 | 2009-04 |
| 3 |
MIROS C - Mothers - 3 months postpartum
|
Data on demographic characteristics, family structure, socio-economic structure, parental behavior and lifestyle, nutrition and medication, parenting style, parental health and physical ... |
2007-03 | 2009-07 |
| 4 |
MIROS C - Mothers - 12 months postpartum
|
Data on demographic characteristics, family structure, socio-economic structure, parental behavior and lifestyle, nutrition and medication, parenting style, parental health and physical ... |
2007-12 | 2010-04 |
Selection Criteria
- Newborns
- Twins
- Countries
-
- Canada
- Territory
- Montreal, Quebec
- Ethnic Origin
-
- Health Status
-
- Supplementary Information about selection criteria
-
- Exclusion criteria:
- Fetuses or infants with known congenital anomalies or chromosomal abnormalities (e.g. Down syndrome);
- Mothers or infants with endocrine disorders: growth hormone deficiency, hyperthyroidism, hypothyroidism, or other known endocrine disorders;
- Mothers or infants with severe illnesses or life threatening conditions: renal failure, active or chronic liver diseases, epilepsy, collagen diseases, serious pulmonary disease, serious hematologic disorders, cancers, heart disease, or other life threatening conditions;
- Infants with several asphyxia (cord arterial blood PH <7.05) or 5-minutes Apgar score <4 (such exposure may affect oxidative stress markers in cord blood samples);
- Fetal or infants deaths (only expected 0 or 1 case whitin the recruited sample).
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
-
- Other specific population : Children of the women already recruited in the study
Number of Participants
- Number of Participants
- 307
- Number of Participants with Biological Samples
- 255
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
MIROS C - Children - Birth
|
Data on birth outcomes (preterm birth, fetal growth, birth weight, gestational age, severe neonatal morbidity) were collected from medical records. | 2006-12 | 2009-04 |
| 1 |
MIROS C - Children - 3 months postpartum
|
Data on nourishment and medical history were collected through questionnaires. Weight, height, arm circumference, blood pressure, pulse, respiratory capacity and temperature were also ... |
2007-03 | 2009-07 |
| 2 |
MIROS C - Children - 12 months postpartum
|
Data on nourishment and medical history were collected through questionnaires. Weight, height, arm circumference, blood pressure, pulse, respiratory capacity and temperature were also ... |
2007-12 | 2010-04 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
Socio-demographic and economic characteristics
Lifestyle and behaviours
Birth, pregnancy and reproductive health history
Diseases
Symptoms and signs
Medication and supplements
Health and community care services utilization
Physical measures and assessments
Laboratory measures
Cognition, personality and psychological measures and assessments
Physical environment
Administrative information