Mayo Clinic Study of Aging
The objectives of the Mayo Clinic Study of Aging were to determine in the population of Olmsted County:
- the prevalence of mild cognitive impairment;
- the incidence of mild cognitive impairment;
- the conversion rates from mild cognitive impairment to dementia or Alzheimer's disease;
- the risk factors for mild cognitive impairment;
- the risk factors for the progression from mild cognitive impairment to dementia or Alzheimer's disease;
- develop risk models to predict MCI or dementia (including Alzheimer's disease).
- Start Year
- 2004
- Supplementary Information
-
Number with follow-up visits is shown below:
Visits Frequency Percent
-------------------------------
1+ 4801 100.00
2+ 3609 75.17
3+ 2499 52.05
4+ 1754 36.53
5+ 1261 26.27
6+ 849 17.68
7+ 562 11.71
8 125 2.60
Visit MCSA
| Investigators | Contacts |
|---|---|
|
|
Design
- Study design
- Cohort
- Follow Up
-
First recruitment started in October 2004; the replenishment of the cohort make up for attrition due to death, refusal, or inability to contact began in 2008 and 2009. Recruitment is ongoing to maintain a sample size of approximately 3,000. The follow-up interval was approximately 15 months.
- Supplementary Information
Marker Paper
Roberts RO, Geda YE, Knopman DS, et al. The Mayo Clinic Study of Aging: design and sampling, participation, baseline measures and sample characteristics. Neuroepidemiology, 2008; 30(1): 58-69.
PUBMED 18259084
Recruitment
- Recruitment Target
-
- Individuals
Number of Participants
- Number of Participants
- No Limit
- Number of Participants with Biological Samples
- No Limit
- Supplementary Information
-
The goal is to maintain approximately 3,000 active participants.
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Timeline
Populations
Olmsted County residents aged 70 to 89 years on October 1st 2004, were randomly selected from an enumeration of the County population using an age and sex stratified sampling scheme. Participants return for follow-up evaluations every 12-15 months on average.
Selection Criteria
- Minimum age
-
70
- Maximum age
-
89
- Newborns
- Twins
- Countries
-
- United States of America
- Territory
-
Olmsted County
- Ethnic Origin
-
- Health Status
-
- Persons with a confirmed diagnosis of dementia were initially excluded, but since 2014 are now being recruited where possible
- Persons who are terminally ill and unable to provide information, or are in hospice are not included.
Recruitment
- Sources of recruitment
-
- General population
- Supplementary Information
-
Participants were randomly selected from the Olmsted County, MN population. Prior to recruitment, the entire Olmsted County population in the target age-range was enumerated using the Rochester Epidemiology Project medical records-linkage system, an extensive system based on surgical and medical diagnoses maintained by the Mayo Clinic. The population was first resampled in 2008 in order to replenish the cohort. Replenishment is ongoing to ensure an active cohort of about 3,000 participants.
Number of Participants
- Number of Participants
- No Limit
- Number of Participants with Biological Samples
- No Limit
- Supplementary Information about selection criteria
-
Over 4600 participants have been evaluated in person (face-to-face) evaluation since onset of the study.
Numbers of participants with one or more visits:
Baseline: 4801 participants
Follow-up 1: 3609 participants
Follow-up 2: 2499 participants
Follow-up 3: 1754 participants
Follow-up 4: 1261 participants
Follow-up 5: 849 participants
Follow-up 6: 562 participants
Follow-up 7: 125 participants
Over 2500 participants have undergone MRI, 1200 or more have at least one follow-up scan .
Over 1,400 have undergone MRI and PET scanning; 400 or more have at least one follow-up scan.
Lumber puncture to obtain cerebrospinal fluid has been performed in over 812 participants; 137 have at least one follow-up CSF samples.
Data Collection Events
| # | Name | Description | Start | End | ||
|---|---|---|---|---|---|---|
| 0 |
MCSA - 70-89 years old - Baseline
|
The in-person evaluation was performed at the Mayo Clinic Abigail Van Buren Alzheimer's Disease Research Clinic or at the
MCSA - 70-89 years old - Follow-up 1
|
The in-person evaluation was performed at the Mayo Clinic Abigail Van Buren Alzheimer's Disease Research Clinic or at the
MCSA - 70-89 years old - Follow-up 2
|
The population was resampled in 2008 and 2009 in order to replenish the cohort. The in-person evaluation was performed at the Mayo Clinic Abigail Van Buren Alzheimer's Disease ... |
2007-04 | 2010-01 |
| 3 |
MCSA - 70-89 years old - Follow-up 3
|
Replenishment of the population was ongoing to ensure an active cohort of about 3000 participants. The in-person evaluation was performed at the Mayo Clinic Abigail Van Buren ... |
2008-07 | 2011-04 | ||
| 4 |
MCSA - 70-89 years old - Follow-up 4
|
Replenishment of the population was ongoing to ensure an active cohort of about 3000 participants. The in-person evaluation was performed at the Mayo Clinic Abigail Van Buren ... |
2009-10 | 2012-07 | ||
| 5 |
MCSA - 70-89 years old - Follow-up 5
|
Replenishment of the population was ongoing to ensure an active cohort of about 3000 participants. The in-person evaluation was performed at the Mayo Clinic Abigail Van Buren ... |
2011-01 | 2013-10 | ||
| 6 |
MCSA - 70-89 years old - Follow-up 6
|
Replenishment of the population was ongoing to ensure an active cohort of about 3000 participants. The in-person evaluation was performed at the Mayo Clinic Abigail Van Buren ... |
2012-04 | 2015-01 | ||
| 7 |
MCSA - 70-89 years old - Follow-up 7
|
Replenishment of the population is ongoing to ensure an active cohort of about 3000 participants. The in-person evaluation was performed at the Mayo Clinic Abigail Van Buren ... |
2013-07 | 2016-04 |
Recruitment of a middle-aged cohort aged 50-69 years old began in 2012 and is ongoing.
Residents of Olmsted County aged 50 to 69 years in 2012, were randomly selected from an enumeration of the County population using an age and sex stratified sampling scheme. Participants return for follow-up evaluations every 12-15 months on average.
Selection Criteria
- Minimum age
-
50
- Maximum age
-
69
- Newborns
- Twins
- Countries
-
- United States of America
- Territory
-
Olmsted County
- Ethnic Origin
-
- Health Status
-
- Persons with a confirmed diagnosis of dementia were initially excluded, but since 2014 are now being recruited where possible
- Persons who are terminally ill and unable to provide information, or are in hospice are not included.
Recruitment
- Sources of recruitment
-
- General population
- Supplementary Information
-
Participants were randomly selected from the Olmsted County, MN population. Prior to recruitment, the entire Olmsted County population in the target age-range was enumerated using the Rochester Epidemiology Project medical records-linkage system, an extensive system based on surgical and medical diagnoses maintained by the Mayo Clinic. The population was first resampled in 2008 in order to replenish the cohort. Replenishment is ongoing to ensure an active cohort of about 3,000 participants. Recruitment of a middle-aged cohort aged 50-69 years old began in 2012 and is also ongoing.
Number of Participants
- Number of Participants
- Number of Participants with Biological Samples
Data Collection Event
The in-person evaluation was performed at the Mayo Clinic Abigail Van Buren Alzheimer's Disease Research Clinic or at the participant's residence using a standardized protocol.
Each participant received an evaluation by a study coordinator, who collected information regarding demographic characteristics, medical history, family history, and medications. Blood draw was performed on all participants. Blood pressure, height, weight and frailty were measured.
The study coordinator also interviewed a partner about the study participant and completed a modified Clinical Dementia Rating to assess the cognition and functional activities of the participant.
A physician performed a medical history review, mental status examination, and neurological examination.
A neuropsychological evaluation with 9 tests was performed, comprising 4 cognitive domains (executive function, language, memory and visuospatial).
Subjects who refused the in-person interview were invited to participate in a structured telephone interview by trained study assistants to collect information on education, occupation, marital status and residence, and to assess cognitive function.
- Start Date
-
2012
- End Date
-
2014
- Data sources
-
- Questionnaires
- Cognitive measures
- Physical measures
- Biosamples
- Data sources - Biosamples
-
- Blood
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
- Cognitive functioning
- Personality
- Psychological distress and emotions
- Other psychological measures and assessments
- Tobacco
- Alcohol
- Drugs
- Nutrition
- Breastfeeding
- Physical activity
- Sleep
- Sexual behaviours and orientation
- Technological devices
- Misbehaviour and criminality
- Other and unspecified lifestyle information
Socio-demographic and economic characteristics
Lifestyle and behaviours
Perception of health, quality of life, development and functional limitations
Diseases
Symptoms and signs
Medication and supplements
Non-pharmacological interventions
Health and community care services utilization
Death
Physical measures and assessments
Laboratory measures
Cognition, personality and psychological measures and assessments
Social environment and relationships
Physical environment
Administrative information
Cognitive functioning
Psychological distress and emotions
Alcohol
Nutrition
Sleep