Sydney Memory and Aging Study
The objectives of the Sydney MAS study are:
- To examine the clinical characteristiques and prevalence of mild cognitive impairment and related syndromes in non-demented older Australians;
- To determine the rate of change in cognitive function over time;
- To examine predictors of cognitive decline from sociodemographic, clinical, neuropsychological, neuroimaging, biochemical, genetics and proteomics perspectives;
- To assess behavioral and psychological symptoms in mild cognitive impairment.
- Start Year
- 2005
Visit SydneyMAS
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Design
- Study design
- Cohort
- Follow Up
- The baseline assessment was repeated at two-yearly intervals, with repeat blood sampling and MRI scans occurring in waves 1, 2 and 4 (+ wave 7 for blood sample). In the intervening years, participants were contacted by telephone for a brief assessment.
- Supplementary Information
Marker Paper
Sachdev PS, et al. The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological non-demented cohort of Australians aged 70-90 years. Int Psychogeriatr, 2010; 22(8): 1248-64.
PUBMED 20637138
Recruitment
- Recruitment Target
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- Individuals
Number of Participants
- Number of Participants
- 1,037
- Number of Participants with Biological Samples
- 943
- Supplementary Information
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
MRI data (raw images and extracted features); blood-derived measures (e.g. genetics measures, proteomics).
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Timeline
SydneyMAS population
The population is composed of individual aged 70 to 90 years and living in the community of Kingsford-Smith and Wentworth, New South Wales.
Selection Criteria
- Minimum age
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70
- Maximum age
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90
- Newborns
- Twins
- Countries
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- Australia
- Territory
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Kingsford-Smith and Wentworth, New South Wales.
- Ethnic Origin
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- Health Status
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- Other Criteria
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Participants had to speak and write English sufficiently well to complete a psychometric assessment and were able to consent to participate.
The participants were excluded if they had a previous diagnosis of dementia, psychotic symptoms or a diagnosis of schizophrenia or bipolar disorder, multiple sclerosis, motor neuron disease, developmental disability, progressive malignancy, or if they had medical or psychological conditions that may have prevented them from completing assessments.Participants were excluded if they had a MMSE score of less than 24 at study entry or if they received a diagnosis of dementia after comprehensive assessment.
Recruitment
- Sources of recruitment
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- General population
- General Population
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- Selected sample
- Supplementary Information
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Participants were recruited randomly through the electoral roll from two federal government areas.
Number of Participants
- Number of Participants
- 1,037
- Number of Participants with Biological Samples
- 943
- Supplementary Information about selection criteria
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Wave 1: Baseline assessment (1037 participants), blood tests (943 participants) and MRI (544 participants)
1-year phone interview: 970 participants
Wave 2: 2-year assessment (889 participants), blood tests (722 participants) and MRI (425 participants)
3-year phone interview: 839 participants
Wave 3: 4-year assessment (792 participants)
5-year phone interview: 751 participants
Wave 4: 6-year assessment (708 participants), blood tests (533 participants) and MRI (265 participants)
7-year phone interview: 644 participants
Wave 5: 8-year assessment (574 participants, under review)
9-year phone interview: 517 participants (under review)
Wave 6: 465 participants (under review)
11-year phone interview: 254 participants (ongoing)
Wave 7: 57 participants (ongoing)
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
SydneyMAS - Wave 1
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Participants were assessed at either a study center or in their own homes if they were unable to visit the center. The face-to-face assessment comprised a medical history interview and a ... | 2005-09 | 2007-12 |
| 1 |
SydneyMAS - 1-year phone interview
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The telephone interview included an update of the social and demographic data of the participant and informant and the telephone interview for cognitive status. |
2006-10 | 2008-12 |
| 2 |
SydneyMAS - Wave 2
|
Participants were assessed at either a study center or in their own homes if they were unable to visit the center. The face-to-face assessment comprised a medical history interview and a ... | 2007-10 | 2009-12 |
| 3 |
SydneyMAS - 3-year phone interview
|
The telephone interview included an update of the social and demographic data of the participant and informant and the telephone interview for cognitive status. |
2008-10 | 2010-12 |
| 4 |
SydneyMAS - Wave 3
|
Participants were assessed at either a study center or in their own homes if they were unable to visit the center. The face-to-face assessment comprised a medical history interview and a ... | 2009-10 | 2011-12 |
| 5 |
SydneyMAS - 5-year phone interview
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The telephone interview included an update of the social and demographic data of the participant and informant and the telephone interview for cognitive status. |
2010-10 | 2012-12 |
| 6 |
SydneyMAS - Wave 4
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Participants were assessed at either a study center or in their own homes if they were unable to visit the center. The face-to-face assessment comprised a medical history interview and a ... | 2011-10 | 2014-03 |
| 7 |
SydneyMAS - 7-year phone interview
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The telephone interview included an update of the social and demographic data of the participant and informant and the telephone interview for cognitive status. |
2012-10 | 2014-12 |
| 8 |
SydneyMAS - Wave 5
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Participants were assessed over the phone only. The medical history interview included questions about depression and anxiety, subjective cognitive decline, self-ratings of activities of daily ... | 2013-10 | 2016-03 |
| 9 |
SydneyMAS - 9-year phone interview
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The telephone interview included an update of the social and demographic data of the participant and informant and the telephone interview for cognitive status. |
2014-11 | 2017-03 |
| 10 |
SydneyMAS - Wave 6
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Participants were assessed at either a study center or in their own homes if they were unable to visit the center. The face-to-face assessment comprised a medical history interview and a ... | 2016-03 | 2018-09 |
| 11 |
SydneyMAS - 11-year phone interview
|
The telephone interview included an update of the social and demographic data of the participant and informant and the telephone interview for cognitive status. |
2017-03 | |
| 12 |
SydneyMAS - Wave 7
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Participants were assessed in their own homes. The face-to-face assessment comprised a medical history interview and a neuropsychological and medical examination. The comprehensive ... | 2018-09 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
- Cognitive functioning
- Personality
- Psychological distress and emotions
- Other psychological measures and assessments
- Life events
- Beliefs and values
- Perception of health
- Quality of life
- Life course development
- Functional limitations
- Other perception of health, quality of life and functional limitation-related information
Socio-demographic and economic characteristics
Lifestyle and behaviours
Birth, pregnancy and reproductive health history
Perception of health, quality of life, development and functional limitations
Diseases
Symptoms and signs
Medication and supplements
Non-pharmacological interventions
Health and community care services utilization
Death
Physical measures and assessments
Laboratory measures
Cognition, personality and psychological measures and assessments
Life events, life plans, beliefs and values
Preschool, school and work life
Social environment and relationships
Physical environment
Administrative information
Cognitive functioning
Personality
Psychological distress and emotions
Life events
Quality of life
Functional limitations