Longitudinal study on prevalence, incidence and persistence of SARS-CoV-2 antibodies in health care workers using home blood collection kits and a fully automated ELISA and ECLIA antibody assay
Networks
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Datasets
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Variables
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The objectives of this study are:
1. To compare home blood collection kit using a micro-tube or a dried blood spot.
2. To provide rates of previous and new infections with COVID-19 and re-infection rates in health care workers (HCWs). This should help to understand if immunity is durable and provides future resistance to COVID-19 infection.
- Start Year
- 2020
- End Year
- 2022
| Investigators | Contacts |
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Design
- Study design
- Cohort
- Follow Up
- For the longitudinal participants, follow-up questionnaires were completed at 3, 6, 12 and 18 months following the initial assays; and 30 days after the completion of the vaccination. An identical process was followed for the serological testing 3, 6, 12 and 18 months following the initial assays; and 30 days after the completion of vaccination.
Recruitment
- Recruitment Target
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- Individuals
Number of Participants
- Number of Participants
- 1,720
- Number of Participants with Biological Samples
- 1,720
- Supplementary Information
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COVID-19 infected: 10 participants
COVID-19 negative and untested: 10 participants
Mount Sinai Hospital: 1200 Participants
Health Science North (Sudbury): 250 Participants
Sault Area Hospital (Sault Ste Marie): 250 Participants
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Timeline
Populations
The population is composed of COVID-19 positive and recovered patients from Mount Sinai Hospital with a previous COVID-19 positive test by naso-pharyngeal swab.
Selection Criteria
- Newborns
- Twins
- Countries
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- Canada
- Territory
- Toronto
- Ethnic Origin
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- Health Status
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- COVID-19 positive and recovered
Recruitment
- Sources of recruitment
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- Specific population
- Specific Population
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- Clinic patients
- Supplementary Information
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COVID-19 positive and recovered patients are recruited from Mount Sinai Hospital patient population. Patients are approached to participate, then they are provided with the consent form and information on how to contact the research coordinator for this study. The COVID-19 infected patients participate in this study after they have recovered from the infection and are no longer infected (not hospitalized patients).
Number of Participants
- Number of Participants
- 10
- Number of Participants with Biological Samples
- 10
Data Collection Event
Blood was collected by skin puncture in a micro-tube and on a dried blood spot.
If participants are unwilling or unable to provide a blood sample using capillary blood, blood was obtained using a venous phlebotomy.
- Start Date
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2020-09
- Data sources
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- Biosamples
- Data sources - Biosamples
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- Blood
The population is composed of health care workers at the Mount Sinai Hospital, COVID-19 untested or previously negative.
Selection Criteria
- Newborns
- Twins
- Countries
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- Canada
- Territory
- Toronto
- Ethnic Origin
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- Health Status
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- COVID-19 untested or previously negative
Recruitment
- Sources of recruitment
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- Specific population
- Specific Population
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- Members of an association
- Supplementary Information
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Participants will be recruited by word of mouth from within the health care workers at the Mount Sinai Hospital.
Number of Participants
- Number of Participants
- 10
- Number of Participants with Biological Samples
- 10
Data Collection Event
Blood was collected by skin puncture in a micro-tube and on a dried blood spot.
If participants are unwilling or unable to provide a blood sample using capillary blood, blood was obtained using a venous phlebotomy.
- Start Date
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2020-09
- Data sources
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- Biosamples
- Data sources - Biosamples
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- Blood
The population is composed of Mount Sinai Hospital (MSH), Sault Area Hospital and Health Sciences North (Sudbury) health care workers.
Selection Criteria
- Newborns
- Twins
- Countries
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- Canada
- Territory
- Ethnic Origin
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- Health Status
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- Other Criteria
- Exclusion: Present symptoms compatible with COVID-19 infections and for those with confirmed COVID-19 positive had a negative NP swab test for COVID-19 (recovered from COVID-19)
Recruitment
- Sources of recruitment
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- Specific population
- Specific Population
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- Members of an association
- Supplementary Information
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Information about this study was electronically distributed to the health care workers (HCWs) at the Mount Sinai Hospital, Sault Area Hospital and Health Sciences North (Sudbury). Volunteers will contact the research coordinator and will be eligible to participate in the study if they are able to provide the blood samples and if they are willing to complete the entire 18 months of the study.
Number of Participants
- Number of Participants
- 1,700
- Number of Participants with Biological Samples
- 1,700
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
LSPIPSA-HCW - Longitudinal - Blood collection
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Information was collected about type of work, age, sex, race/ethnicity, simple demographic and pre-existing medical issues on the risks of infection with COVID-19 and the severity of the infection ... | 2020-09 | |
| 1 |
LSPIPSA-HCW - Longitudinal - 3 months follow-up
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Information was collected about COVID-19 diagnosis and history of symptoms compatible with an infection with COVID-19. Serology testing was done. | 2020-12 | |
| 2 |
LSPIPSA-HCW - Longitudinal - 6 months follow-up
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Information was collected about COVID-19 diagnosis and history of symptoms compatible with an infection with COVID-19. Serology testing was done. | 2021-03 | |
| 3 |
LSPIPSA-HCW - Longitudinal - 12 months follow-up
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Information was collected about COVID-19 diagnosis and history of symptoms compatible with an infection with COVID-19. Serology testing was done. | 2021-09 | |
| 4 |
LSPIPSA-HCW - Longitudinal - 18 months follow-up
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Information was collected about COVID-19 diagnosis and history of symptoms compatible with an infection with COVID-19. Serology testing was done. | 2022-03 | 2022 |
| 5 |
LSPIPSA-HCW - Longitudinal - 1 month post-vaccination
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Information was collected about COVID-19 diagnosis and history of symptoms compatible with an infection with COVID-19. Serology testing was done. | 2021-02 | 2021 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
Socio-demographic and economic characteristics
Age/birthdate
Sex/gender
Residence
Ethnicity, race and religion
Labour force and retirement
Lifestyle and behaviours
Tobacco
Diseases
Certain infectious and parasitic diseases (A00-B99)
Neoplasms (C00-D48)
Diseases without precise specification or falling into multiple categories
Medication and supplements
Medication and supplement intake
Non-pharmacological interventions
Laboratory diagnosis interventions
Other and unspecified non-pharmacological interventions
Physical measures and assessments
Anthropometry
Laboratory measures
Virology
Preschool, school and work life
Work life
Social environment and relationships
Social participation
Administrative information
Identifiers
Date and time-related information