Individual Study / LIR-SARS-CoV-2

Fine Analysis of Longitudinal Immune Responses to SARS-CoV-2 in Vaccination: Harnessing the Power of ‘Stop The Spread Ottawa’ to Understand Immune Protection in COVID-19
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Fine Analysis of Longitudinal Immune Responses to SARS-CoV-2 in Vaccination: Harnessing the Power of ‘Stop The Spread Ottawa’ to Understand Immune Protection in COVID-19

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Datasets -
Variables -
Start Year
2020
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Investigators Contacts
  • Dr. Jörg Hermann Fritz
    McGill University
  • Dr. Miroslava Cuperlovic-Culf
    University of Ottawa
  • Dr. Steffany Bennett
    University of Ottawa
  • Dr. Amy Hsu
    University of Ottawa
  • Dr. Angela M. Crawley
    University of Ottawa
  • Dr. Ciriaco A. Piccirillo
    Department of Microbiology and Immunology
  • Dr. Curtis Cooper
    Ottawa Hospital Research Institute
  • Dr. Marc-André Langlois
    University of Ottawa
  • Dr. Angela M. Crawley
    University of Ottawa

Design

Study design
Cohort
Follow Up
Participants who test positive for COVID-19 or are at high risk of exposure provide monthly blood and saliva samples over a 10-month period (between October 2021 - October 2022). A subgroup of participants (300) will continue to provide bimonthly blood samples for up to 24 months (ie. until approximately September 2024).

Recruitment

Recruitment Target
  • Individuals

Number of Participants

Number of Participants
1,000
Number of Participants with Biological Samples
1,000

Access

Availability of data and biosamples

Possible Access to Data
Possible Access to Biosamples
Other
Yes
No
Not applicable
Don't know

Timeline

Populations

Selection Criteria
Minimum age
18
Newborns
Twins
Countries
  • Canada
Territory
Ottawa
Ethnic Origin
Health Status
  • Individuals who have HIV, chronic viral hepatitis, and hematologic malignancy were included in the study.
Other Criteria
Individuals who are healthcare workers, long-term care facility staff, transportation workers, homeless shelter staff, dentists/allied dental care workers, elementary and secondary school teachers, elderly individuals living in high-density, long-term retirement homes, and daycare workers.
Supplementary Information about selection criteria

Recruitment

Sources of recruitment
  • General population
  • Participants from existing studies
Supplementary Information
Participants were recruited through the study website, by distributing the promotional materials to healthcare and dental staff, teachers, and transportation workers; and through collaboration with organizations representing key target populations.
Participants from Existing Studies
  • Stop-the-Spread Ottawa (SSO).

Number of Participants

Number of Participants
300
Number of Participants with Biological Samples
300
Supplementary Information about selection criteria
Initially there were 500 individulas in the Surveillance Cohort. Some vaccinated participants in the Surveillance Cohort were also asked to transfer to the Convalescent Cohort. Approximately 200 participants without history of SARS-CoV-2 infection have transferred.
Data Collection Events
# Name Description Start End
0 LIR-SARS-Cov-2 - Surveillance Cohort - Baseline Information on demographics (e.g., age, ethnic group, gender), health history (e.g., vaccinations, medications), severity of COVID-19 signs and symptoms, risks of the SARS-CoV-2 exposure, ... 2020 2021-11
1 LIR-SARS-Cov-2 - Surveillance Cohort - 1st month collection Dried blood spot and saliva samples are collected. 2021-12
2 LIR-SARS-Cov-2 - Surveillance Cohort - 2nd month collection Dried blood spot and saliva samples are collected. 2022-01
3 LIR-SARS-Cov-2 - Surveillance Cohort - 3rd month collection Information on demographics (e.g., age, ethnic group, gender), health history (e.g., vaccinations, medications), severity of COVID-19 signs and symptoms, risks of the SARS-CoV-2 exposure, ... 2022-02
4 LIR-SARS-Cov-2 - Surveillance Cohort - 4th month collection Dried blood spot and saliva samples are collected. 2022-03
5 LIR-SARS-Cov-2 - Surveillance Cohort - 5th month collection Dried blood spot and saliva samples are collected. 2022-04
6 LIR-SARS-Cov-2 - Surveillance Cohort - 6th month collection Dried blood spot and saliva samples are collected. 2022-05
7 LIR-SARS-Cov-2 - Surveillance Cohort - 7th month collection Dried blood spot and saliva samples are collected. 2022-06
8 LIR-SARS-Cov-2 - Surveillance Cohort - 8th month collection Dried blood spot and saliva samples are collected. 2022-07
9 LIR-SARS-Cov-2 - Surveillance Cohort - 9th month collection Dried blood spot and saliva samples are collected. 2022-08
10 LIR-SARS-Cov-2 - Surveillance Cohort - 10th month collection Information on demographics (e.g., age, ethnic group, gender), health history (e.g., vaccinations, medications), severity of COVID-19 signs and symptoms, risks of the SARS-CoV-2 exposure, ... 2022-09
11 LIR-SARS-Cov-2 - Surveillance Cohort - Extension - 12th month collection Blood samples are collected. 2022-11
12 LIR-SARS-Cov-2 - Surveillance Cohort - Extension - 14th month collection Blood samples are collected. 2023-01
13 LIR-SARS-Cov-2 - Surveillance Cohort - Extension - 16th month collection Information on demographics (e.g., age, ethnic group, gender), health history (e.g., vaccinations, medications), severity of COVID-19 signs and symptoms, risks of the SARS-CoV-2 exposure, ... 2023-03
14 LIR-SARS-Cov-2 - Surveillance Cohort - Extension - 18th month collection Blood samples are collected. 2023-05
15 LIR-SARS-Cov-2 - Surveillance Cohort - Extension - 20th month collection Blood and saliva samples are collected. 2023-07
16 LIR-SARS-Cov-2 - Surveillance Cohort - Extension - 22nd month collection Information on demographics (e.g., age, ethnic group, gender), health history (e.g., vaccinations, medications), severity of COVID-19 signs and symptoms, risks of the SARS-CoV-2 exposure, ... 2023-09
17 LIR-SARS-Cov-2 - Surveillance Cohort - Extension - 24nd month collection Blood and saliva samples are collected. 2023-11
18 LIR-SARS-Cov-2 - Surveillance Cohort - Extension - 26th month collection Blood samples are collected. 2024-01
19 LIR-SARS-Cov-2 - Surveillance Cohort - Extension - 28th month collection Information on demographics (e.g., age, ethnic group, gender), health history (e.g., vaccinations, medications), severity of COVID-19 signs and symptoms, risks of the SARS-CoV-2 exposure, ... 2024-03
20 LIR-SARS-Cov-2 - Surveillance Cohort - Extension - 30th month collection Blood samples are collected. 2024-05
21 LIR-SARS-Cov-2 - Surveillance Cohort - Extension - 32nd month collection Blood and saliva samples are collected. 2024-07
22 LIR-SARS-Cov-2 - Surveillance Cohort - Extension - 34th month collection Information on demographics (e.g., age, ethnic group, gender), health history (e.g., vaccinations, medications), severity of COVID-19 signs and symptoms, risks of the SARS-CoV-2 exposure, ... 2024-09
Selection Criteria
Newborns
Twins
Countries
  • Canada
Territory
Ottawa-region
Ethnic Origin
Health Status
  • Individuals known to have current or past COVID-19 infection confirmed by positive SARS-CoV-2 quantitative reverse transcription polymerase chain reaction (RT-PCR) or serology test.

Recruitment

Sources of recruitment
  • General population
General Population
  • Volunteer enrolment
Supplementary Information
Participants were recruited through study website and SARS-CoV-2 antibody results portal; by distributing promotional materials to healthcare and dental staff, teachers, and transportation workers; through collaboration with organizations representing key target populations; and use of EORLA (Eastern Ontario Regional Laboratory Association) reports and The Ottawa Hospital COVID-19 Registry to identify SARS-CoV-2 positive.

Number of Participants

Number of Participants
700
Number of Participants with Biological Samples
700
Data Collection Events
# Name Description Start End
0 LIR-SARS-Cov-2 - Convalescent Cohort - Baseline Information on demographics (e.g., age, ethnic group, gender), health history (e.g., vaccinations, medications), severity of COVID-19 signs and symptoms, risks of the SARS-CoV-2 exposure, ... 2020 2021-11
1 LIR-SARS-Cov-2 - Convalescent Cohort - 1st month collection Blood, dried blood spot and saliva samples are collected. 2021-12
2 LIR-SARS-Cov-2 - Convalescent Cohort - 2nd month collection Blood, dried blood spot and saliva samples are collected. 2022-01
3 LIR-SARS-Cov-2 - Convalescent Cohort - 3rd month collection Information on demographics (e.g., age, ethnic group, gender), health history (e.g., vaccinations, medications), severity of COVID-19 signs and symptoms, risks of the SARS-CoV-2 exposure, ... 2022-02
4 LIR-SARS-Cov-2 - Convalescent Cohort - 4th month collection Blood, dried blood spot and saliva samples are collected. 2022-03
5 LIR-SARS-Cov-2 - Convalescent Cohort - 5th month collection Blood, dried blood spot and saliva samples are collected. 2022-04
6 LIR-SARS-Cov-2 - Convalescent Cohort - 6th month collection Blood, dried blood spot and saliva samples are collected. 2022-05
7 LIR-SARS-Cov-2 - Convalescent Cohort - 7th month collection Blood, dried blood spot and saliva samples are collected. 2022-06
8 LIR-SARS-Cov-2 - Convalescent Cohort - 8th month collection Blood, dried blood spot and saliva samples are collected. 2022-07
9 LIR-SARS-Cov-2 - Convalescent Cohort - 9th month collection Blood, dried blood spot and saliva samples are collected. 2022-08
10 LIR-SARS-Cov-2 - Convalescent Cohort - 10th month collection Information on demographics (e.g., age, ethnic group, gender), health history (e.g., vaccinations, medications), severity of COVID-19 signs and symptoms, risks of the SARS-CoV-2 exposure, ... 2022-09
11 LIR-SARS-Cov-2 - Convalescent Cohort - Extension - 12th month collection Blood samples are collected. 2022-11
12 LIR-SARS-Cov-2 - Convalescent Cohort - Extension - 14th month collection Blood samples are collected. 2023-01
13 LIR-SARS-Cov-2 - Convalescent Cohort - Extension - 16th month collection Information on demographics (e.g., age, ethnic group, gender), health history (e.g., vaccinations, medications), severity of COVID-19 signs and symptoms, risks of the SARS-CoV-2 exposure, ... 2023-03
14 LIR-SARS-Cov-2 - Convalescent Cohort - Extension - 18th month collection Blood samples are collected. 2023-05
15 LIR-SARS-Cov-2 - Convalescent Cohort - Extension - 20th month collection Blood and saliva samples are collected. 2023-07
16 LIR-SARS-Cov-2 - Convalescent Cohort - Extension - 22th month collection Information on demographics (e.g., age, ethnic group, gender), health history (e.g., vaccinations, medications), severity of COVID-19 signs and symptoms, risks of the SARS-CoV-2 exposure, ... 2023-09
17 LIR-SARS-Cov-2 - Convalescent Cohort - Extension - 24th month collection Blood and saliva samples are collected. 2023-11
18 LIR-SARS-Cov-2 - Convalescent Cohort - Extension - 26th month collection Blood samples are collected. 2024-01
19 LIR-SARS-Cov-2 - Convalescent Cohort - Extension - 28th month collection Information on demographics (e.g., age, ethnic group, gender), health history (e.g., vaccinations, medications), severity of COVID-19 signs and symptoms, risks of the SARS-CoV-2 exposure, ... 2024-03
20 LIR-SARS-Cov-2 - Convalescent Cohort - Extension - 30th month collection Blood and saliva samples are collected. 2024-05
21 LIR-SARS-Cov-2 - Convalescent Cohort - Extension - 32nd month collection Blood and saliva samples are collected. 2024-07
22 LIR-SARS-Cov-2 - Convalescent Cohort - Extension - 34th month collection Information on demographics (e.g., age, ethnic group, gender), health history (e.g., vaccinations, medications), severity of COVID-19 signs and symptoms, risks of the SARS-CoV-2 exposure, ... 2024-09

Classifications

Socio-demographic and economic characteristics
Lifestyle and behaviours
Birth, pregnancy and reproductive health history
Perception of health, quality of life, development and functional limitations
Diseases
Symptoms and signs
Medication and supplements
Non-pharmacological interventions
Health and community care services utilization
Death
Physical measures and assessments
Laboratory measures
Cognition, personality and psychological measures and assessments
Life events, life plans, beliefs and values
Preschool, school and work life
Social environment and relationships
Physical environment
Administrative information
Cognitive functioning
Personality
Psychological distress and emotions
Other psychological measures and assessments

Socio-demographic and economic characteristics

Age/birthdate
Sex/gender
Family and household structure
Education
Residence
Birthplace
Citizenship and immigrant status
Ethnicity, race and religion
Labour force and retirement
Income, possessions, and benefits

Lifestyle and behaviours

Tobacco
Alcohol
Transportation
Leisure activities

Birth, pregnancy and reproductive health history

Pregnancy, delivery and birth

Perception of health, quality of life, development and functional limitations

Perception of health
Quality of life

Diseases

Certain infectious and parasitic diseases (A00-B99)
Neoplasms (C00-D48)
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
Endocrine, nutritional and metabolic diseases (E00-E90)
Mental and behavioural disorders (F00-F99)
Diseases of the nervous system (G00-G99)
Diseases of the ear and mastoid process (H60-H95)
Diseases of the circulatory system (I00-I99)
Diseases of the respiratory system (J00-J99)
Diseases of the digestive system (K00-K93)
Diseases of the musculoskeletal system and connective tissue (M00-M99)
Diseases of the genitourinary system (N00-N99)
Injury, poisoning and certain other consequences of external causes (S00-T98)
External causes of morbidity and mortality (V01-Y98)
Diseases without precise specification or falling into multiple categories

Symptoms and signs

Symptoms and signs involving the circulatory and respiratory systems (R00-R09)
Symptoms and signs involving the digestive system and abdomen (R10-R19)
Symptoms and signs involving the skin and subcutaneous tissue (R20-R23)
Symptoms and signs involving nervous and musculoskeletal systems (R25-R29)
Symptoms and signs involving cognition, perception, emotional state and behaviour (R40-R46)
Symptoms and signs involving speech and voice (R47-R49)
General symptoms and signs (R50-R69)
Symptoms related to multiple categories

Medication and supplements

Medication and supplement intake
Posology and protocol of administration

Non-pharmacological interventions

Surgical interventions
Laboratory diagnosis interventions
Other and unspecified non-pharmacological interventions

Health and community care services utilization

Visits to health professionals
Hospitalizations

Physical measures and assessments

Anthropometry

Laboratory measures

Virology

Cognition, personality and psychological measures and assessments

Psychological distress and emotions

Preschool, school and work life

Work life

Social environment and relationships

Social network
Social participation

Physical environment

Biological exposure

Administrative information

Identifiers
Date and time-related information
Questionnaire and interview-related information
Physical and cognitive measure and biosample-related information
Other administrative information

Psychological distress and emotions

Impact of Events Scale-Revised
Kessler Psychological Distress Scale