LifeLines Cohort Study & Biobank
Overall aim of the LifeLines study is to unravel the interaction between genetic and environmental factors in the development of multifactorial diseases, their concurrent development in individuals and their complications as a complex trait. The primary objectives are to establish which are the disease overriding risk factors which predict the development of a multifactorial disease during lifetime, and how are these universal risk factors modified, or what determines the effect of a universal risk factor in an individual. Specific research questions will focus on risk factors and modifiers (genetic, environmental and combined or complex factors) for single and multiple diseases. In addition to co-morbidity, LifeLines focuses on co-determinants. The primary endpoints include measures of ageing, metabolic and endocrine diseases, cardiology, renal diseases, pulmonary and musculoskeletal diseases, and psychopathology. Secondary objectives include the assessment of the prevalence and incidence of multifactorial diseases and their risk factors in individuals as well as in families. The burden of disease for the society will be quantified in terms of care needed, and total costs of care.
- Start Year
- 2007
- Supplementary Information
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Funding Agencies: Governement, 3 northern provinces of The Netherlands (80%), University Med Center Groningen/ University of Groningen (15%), The Netherlands Organization for Scientific Research (NWO) (5%), Dutch Diabetes Research Foundation and Dutch Kidney Foundation
Visit LifeLines
| Investigators | Contacts |
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Design
- Study design
- Cohort
- Follow Up
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The participants are followed for at least thirty years and are invited every five years for a medical examination. In the years in-between (every 1.5 years) the participants recieve follow-up questionnaires.
Marker Paper
Stolk RP, Rosmalen JG, Postma DS, de Boer RA, Navis G, Slaets JP, Ormel J, Wolffenbuttel BHR. Universal risk factors for multifactorial diseases: LifeLines: a three-generation population-based study. Eur J Epidemiol 2008; 23(1): 67-74.
PUBMED 18075776
Recruitment
- Recruitment Target
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- Individuals
- Families
Number of Participants
- Number of Participants
- 165,000
- Number of Participants with Biological Samples
- 165,000
- Supplementary Information
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45 000 probands who invite their family members (30000 partners, 55000 parents (including in laws) and 35000 children).
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Timeline
LifeLines Population
The study population consists of a representative sample of the population of the northern provinces of the Netherlands, covering three generations. The LifeLines project will include 165.000 participants: anticipated to consist of approximately45.000 probands, 30.000 partners, 55.000 parents-(in law) and 35.000 children. Based on the age of the participant, he or she is included in the children’s cohort (0-18 years), the adult cohort (18-65 years) or the elderly cohort (>65 years).
Selection Criteria
- Newborns
- Twins
- Countries
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- Netherlands
- Territory
- Groningen, Friesland and Drenthe
- Ethnic Origin
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- Health Status
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- Severe psychiatric or physical illness are excluded
Recruitment
- Sources of recruitment
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- General population
- General Population
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- Volunteer enrolment
- Participants from Existing Studies
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Number of Participants
- Number of Participants
- 165,000
- Number of Participants with Biological Samples
- 165,000
- Supplementary Information about selection criteria
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155000 participants as of 19 Sept 2013
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
Lifelines - Preparation phase/pilot
|
2004 | 2006 | |
| 1 |
Lifelines - Baseline visit
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Baseline visit of participants. Questionnaires: Demographics, Family composition, Work and educational level, Health, Birth and development, Lifestyle ... |
2007 | 2013 |
| 2 |
Lifelines - Follow-up questionnaire 1
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Follow-up of participant at approx 2 years after Baseline visit. Change of address / change in family members, Incidence of diseases / visits to health care ... |
2010 | 2014 |
| 3 |
Lifelines - Follow-up questionnaire 2
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Follow-up of participants at 3 years after Baseline visit. Change of address / change in family members, Incidence of diseases / visits to health care providers, Medication ... |
2012 | 2015 |
| 4 |
Lifelines - Follow-up visit 1
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Follow-up visit of participants at 5 years after Baseline visit. Questionnaires: Demographics, Family composition, Work and educational ... |
2014 | 2017 |
| 5 |
Lifelines - Follow-up questionnaire 3
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Follow-up of participants at approx. 5 years after Baseline visit. Change of address / change in family members, Incidence of diseases / visits to health care providers, Medication ... |
2014 | 2017 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
- Cognitive functioning
- Personality
- Psychological distress and emotions
- Other psychological measures and assessments
- Life events
- Beliefs and values
- Perception of health
- Quality of life
- Life course development
- Functional limitations
- Other perception of health, quality of life and functional limitation-related information
- Tobacco
- Alcohol
- Drugs
- Nutrition
- Breastfeeding
- Physical activity
- Sleep
- Sexual behaviours and orientation
- Technological devices
- Misbehaviour and criminality
- Other and unspecified lifestyle information
Socio-demographic and economic characteristics
Lifestyle and behaviours
Birth, pregnancy and reproductive health history
Perception of health, quality of life, development and functional limitations
Diseases
Symptoms and signs
Medication and supplements
Non-pharmacological interventions
Health and community care services utilization
Death
Physical measures and assessments
Laboratory measures
Cognition, personality and psychological measures and assessments
Life events, life plans, beliefs and values
Preschool, school and work life
Social environment and relationships
Physical environment
Administrative information
Cognitive functioning
Personality
Psychological distress and emotions
Life events
Quality of life
Functional limitations
Nutrition