Longevity Genes Project
The main purpose of the Longevity Genes Project (LGP) is to identify and characterize factors, biological markers and mechanisms leading to exceptionally long life span in healthy Ashkenazi Jews.
The LPG study is divided into two phases: phase 1 intends to explain the longevity phenotype of this specific population (how Ashkenazi Jews escape or delay many age-related diseases such as cancer, cardiovascular diseases, dementia and infections); whereas phase 2 (LonGenity) serves as a prospective validation cohort to confirm the findings from LGP.
- Start Year
- 1998
Visit LGP
| Investigators | Contacts |
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Design
- Study design
- Case-control
- Follow Up
- Phase 1 participants were visited once by a member of the Einstein Institute for aging research and were not followed-up. Phase 2 participants were followed annually.
- Supplementary Information
Marker Paper
Barzilai N, Atzmon G, Schechter C, Schaefer EJ, Cupples AL, Lipton R, Cheng S, Shuldiner AR. 2014. Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA; 290(15):2030-40.
PUBMED 14559957
Recruitment
- Recruitment Target
-
- Families
Number of Participants
- Number of Participants
- 2,680
- Number of Participants with Biological Samples
- Supplementary Information
- Most super agers were recruited as family units.
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Timeline
Populations
Selection Criteria
- Newborns
- Twins
- Countries
-
- United States of America
- Ethnic Origin
-
- Ashkenazi Jews
- Health Status
-
- Other Criteria
- Participants were excluded if they had a diagnosis of dementia, severe visual or hearing impairments.
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
-
- Other specific population : Offspring of the super agers enrolled in the study.
- Supplementary Information
-
LGP offspring of super agers were recruited between 1998-2007.
Number of Participants
- Number of Participants
- 700
- Number of Participants with Biological Samples
Data Collection Event
Participants were visited at their home by a member of the Einstein Institute for Aging Research.
The visit included a self-reported medical history covering family history, health and lifestyle information, and a cognitive examination was performed.
A physical and physiological examination was done to measure height, weight, waist girth, blood pressure, heart's electrical action and walking ability.
A blood sample was taken.
- Start Date
-
1998
- End Date
-
2007
- Data sources
-
- Questionnaires
- Physical measures
- Biosamples
- Data sources - Biosamples
-
- Blood
Selection Criteria
- Newborns
- Twins
- Countries
-
- United States of America
- Territory
- New York
- Ethnic Origin
-
- Ashkenazi Jews
- Health Status
-
- Supplementary Information about selection criteria
- Participants were excluded if they had a diagnosis of dementia, severe visual or hearing impairments as well as having a sibling already enrolled in the study.
Recruitment
- Sources of recruitment
-
- Specific population
- Participants from existing studies
- Specific Population
-
- Other specific population : Spouses of the Super Agers offspring already enrolled in the study.
- Supplementary Information
-
The spouses were recruited via the super agers' offspring. The other participants were recruited from the Einstein Aging Study.
- Participants from Existing Studies
-
- Einstein Aging Study
Number of Participants
- Number of Participants
- 280
- Number of Participants with Biological Samples
Data Collection Event
Participants were visited at their home by a member of the Einstein Institute for Aging Research.
The visit included a self-reported medical history covering family history, health and lifestyle information, and a cognitive examination was performed.
A physical and physiological examination was done to measure height, weight, waist girth, blood pressure, heart's electrical action and walking ability.
A blood sample was taken.
- Start Date
-
1998
- End Date
-
2007
- Data sources
-
- Questionnaires
- Physical measures
- Biosamples
- Data sources - Biosamples
-
- Blood
Selection Criteria
- Minimum age
-
95
- Newborns
- Twins
- Countries
-
- United States of America
- Territory
- New York area
- Ethnic Origin
-
- Ashkenazi Jews
- Health Status
-
- Other Criteria
- To be eligible, participants were required to be living independently at age 95, as a reflection of good health, although at the time of recruitment they could be at any level of dependency.
Recruitment
- Sources of recruitment
-
- General population
- Participants from existing studies
- General Population
-
- Volunteer enrolment
- Supplementary Information
-
Subjects were recruited by word of mouth and through advertisements in Jewish aging centers and homes. They were recruited from 1998 and are still being recruited.
- Participants from Existing Studies
-
- Some participants were from LonGenity study when they turned 95.
Number of Participants
- Number of Participants
- 600
- Number of Participants with Biological Samples
Data Collection Event
Participants were visited at their home by a member of the Einstein Institute for Aging Research.
The visit included a self-reported health history covering family history, health and lifestyle information, and a cognitive examination was performed.
Height and weight were measured.
A blood sample was taken.
- Start Date
-
1998
- End Date
-
2017
- Data sources
-
- Questionnaires
- Physical measures
- Biosamples
- Data sources - Biosamples
-
- Blood
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- United States of America
- Territory
- New York
- Ethnic Origin
-
- Ashkenazi Jews
- Health Status
-
- Supplementary Information about selection criteria
- Exclusion criterion included diagnosis of dementia, severe visual or hearing impairments as well as having a sibling already enrolled in the study.
Recruitment
- Sources of recruitment
-
- Specific population
- Participants from existing studies
- Specific Population
-
- Other specific population : Ashkenazi Jews (your family was originally from Eastern Europe: Germany, Russia, Poland, Hungary, Czechoslovakia, Rumania, etc.)
- Supplementary Information
-
Participants were recruited from 2008 and are still being recruited. They were recruited using public records such as voter registration lists, contacts at synagogues, community organizations, and advertisements in Jewish newspapers. Some offspring from LGP are included, although this is a minority of subjects.
- Participants from Existing Studies
-
- Longevity Genes Project
- Einstein Aging study
Number of Participants
- Number of Participants
- 530
- Number of Participants with Biological Samples
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
LGP - LonGenity offspring of super agers - Assessment 1
|
Participants were studied annually at Albert Einstein College of Medicine's campus. The visit included a self-reported medical history covering family history, health and lifestyle ... |
2008 | 2017 |
| 1 |
LGP - LonGenity offspring of super agers - Assessment 2
|
Participants were studied annually at Albert Einstein College of Medicine's campus. The visit included a self-reported medical history covering family history, health and lifestyle ... |
2009 | 2017 |
| 2 |
LGP - LonGenity offspring of super agers - Assessment 3
|
Participants were studied annually at Albert Einstein College of Medicine's campus. The visit included a self-reported medical history covering family history, health and lifestyle ... |
2010 | 2017 |
| 3 |
LGP - LonGenity offspring of super agers - Assessment 4
|
Participants were studied annually at Albert Einstein College of Medicine's campus. The visit included a self-reported medical history covering family history, health and lifestyle ... |
2011 | 2017 |
| 4 |
LGP - LonGenity offspring of super agers - Assessment 5
|
Participants were studied annually at Albert Einstein College of Medicine's campus. The visit included a self-reported medical history covering family history, health and lifestyle ... |
2012 | 2017 |
| 5 |
LGP - LonGenity offspring of super agers - Assessment 6
|
Participants were studied annually at Albert Einstein College of Medicine's campus. The visit included a self-reported medical history covering family history, health and lifestyle ... |
2013 | 2017 |
| 6 |
LGP - LonGenity offspring of super agers - Assessment 7
|
Participants were studied annually at Albert Einstein College of Medicine's campus. The visit included a self-reported medical history covering family history, health and lifestyle ... |
2014 | 2017 |
| 7 |
LGP - LonGenity offspring of super agers - Assessment 8
|
Participants were studied annually at Albert Einstein College of Medicine's campus. The visit included a self-reported medical history covering family history, health and lifestyle ... |
2015 | 2017 |
| 8 |
LGP - LonGenity offspring of super agers - Assessment 9
|
Participants were studied annually at Albert Einstein College of Medicine's campus. The visit included a self-reported medical history covering family history, health and lifestyle ... |
2016 | 2017 |
| 9 |
LGP - LonGenity offspring of super agers - Assessment 10
|
Participants were studied annually at Albert Einstein College of Medicine's campus. The visit included a self-reported medical history covering family history, health and lifestyle ... |
2017 | 2017 |
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- United States of America
- Territory
- New York
- Ethnic Origin
-
- Ashkenazi Jews
- Health Status
-
- Supplementary Information about selection criteria
- Exclusion criterion included diagnosis of dementia, severe visual or hearing impairments as well as having a sibling already enrolled in the study.
Recruitment
- Sources of recruitment
-
- Specific population
- Participants from existing studies
- Specific Population
-
- Other specific population : Other specific population Ashkenazi Jews (your family was originally from Eastern Europe: Germany, Russia, Poland, Hungary, Czechoslovakia, Rumania, etc.)
- Supplementary Information
-
Participants were recruited from 2008 and are still being recruited. They were recruited using public records such as voter registration lists, contacts at synagogues, community organizations, and advertisements in Jewish newspapers.Some offspring from LGP are included, although this is a minority of subjects.
- Participants from Existing Studies
-
- Einstein Aging Study
Number of Participants
- Number of Participants
- 570
- Number of Participants with Biological Samples
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
LGP - LonGenity offspring of those with typical survival - Assessment 1
|
Participants were studied annually at Albert Einstein College of Medicine's campus. The visit included a self-reported medical history covering family history, health and lifestyle ... |
2008 | 2017 |
| 1 |
LGP - LonGenity offspring of those with typical survival - Assessment 2
|
Participants were studied annually at Albert Einstein College of Medicine's campus. The visit included a self-reported medical history covering family history, health and lifestyle ... |
2009 | 2017 |
| 2 |
LGP - LonGenity offspring of those with typical survival - Assessment 3
|
Participants were studied annually at Albert Einstein College of Medicine's campus. The visit included a self-reported medical history covering family history, health and lifestyle ... |
2010 | 2017 |
| 3 |
LGP - LonGenity offspring of those with typical survival - Assessment 4
|
Participants were studied annually at Albert Einstein College of Medicine's campus. The visit included a self-reported medical history covering family history, health and lifestyle ... |
2011 | 2017 |
| 4 |
LGP - LonGenity offspring of those with typical survival - Assessment 5
|
Participants were studied annually at Albert Einstein College of Medicine's campus. The visit included a self-reported medical history covering family history, health and lifestyle ... |
2012 | 2017 |
| 5 |
LGP - LonGenity offspring of those with typical survival - Assessment 6
|
Participants were studied annually at Albert Einstein College of Medicine's campus. The visit included a self-reported medical history covering family history, health and lifestyle ... |
2013 | 2017 |
| 6 |
LGP - LonGenity offspring of those with typical survival - Assessment 7
|
Participants were studied annually at Albert Einstein College of Medicine's campus. The visit included a self-reported medical history covering family history, health and lifestyle ... |
2014 | 2017 |
| 7 |
LGP - LonGenity offspring of those with typical survival - Assessment 8
|
Participants were studied annually at Albert Einstein College of Medicine's campus. The visit included a self-reported medical history covering family history, health and lifestyle ... |
2015 | 2017 |
| 8 |
LGP - LonGenity offspring of those with typical survival - Assessment 9
|
Participants were studied annually at Albert Einstein College of Medicine's campus. The visit included a self-reported medical history covering family history, health and lifestyle ... |
2016 | 2017 |
| 9 |
LGP - LonGenity offspring of those with typical survival - Assessment 10
|
Participants were studied annually at Albert Einstein College of Medicine's campus. The visit included a self-reported medical history covering family history, health and lifestyle ... |
2017 | 2017 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
- Cognitive functioning
- Personality
- Psychological distress and emotions
- Other psychological measures and assessments
- Perception of health
- Quality of life
- Life course development
- Functional limitations
- Other perception of health, quality of life and functional limitation-related information
Socio-demographic and economic characteristics
Lifestyle and behaviours
Birth, pregnancy and reproductive health history
Perception of health, quality of life, development and functional limitations
Diseases
Symptoms and signs
Medication and supplements
Non-pharmacological interventions
Health and community care services utilization
Death
Physical measures and assessments
Laboratory measures
Cognition, personality and psychological measures and assessments
Administrative information
Cognitive functioning
Psychological distress and emotions
Quality of life