Maelstrom Research Staging

Hisayama Study

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Datasets -

Variables -

Start Year: 1961

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Investigators	Contacts
Prof. Yutaka Kiyohara Kyushu University Yutaka Kiyohara Title Prof. Name Yutaka Kiyohara Email Kiyohara@envmed.med.kyushu-u.ac.jp Phone 092-642-6104 Institution Kyushu University Department Faculty of Medical Sciences Address Fukuoka Japan Dr. Toshiharu Ninomiya Kyushu University Toshiharu Ninomiya Title Dr. Name Toshiharu Ninomiya Email nino@intmed2.med.kyushu-u.ac.jp Phone 092-642-6151 Institution Kyushu University Department Faculty of Medical Sciences Address Fukuoka Japan Dr. Jun Hata Kyushu University Jun Hata Title Dr. Name Jun Hata Email junhata@envmed.med.kyushu-u.ac.jp Phone 092-642-6107 Institution Kyushu University Department Faculty of Medical Sciences Address Fukuoka Japan Dr. Tomoyuki Ohara Kyushu University Tomoyuki Ohara Title Dr. Name Tomoyuki Ohara Phone 092-642-5627 Institution Kyushu University Department Faculty of Medical Sciences Address Fukuoka Japan	Dr. Toshiharu Ninomiya Kyushu University Toshiharu Ninomiya Title Dr. Name Toshiharu Ninomiya Email nino@intmed2.med.kyushu-u.ac.jp Phone 092-642-6151 Institution Kyushu University Department Faculty of Medical Sciences Address Fukuoka Japan

Investigators

Contacts

Prof. Yutaka Kiyohara
Kyushu University

Yutaka Kiyohara

Title

Prof.

Name

Yutaka Kiyohara

Email

Kiyohara@envmed.med.kyushu-u.ac.jp

Phone

092-642-6104

Institution

Kyushu University

Department

Faculty of Medical Sciences

Address

Fukuoka Japan
Dr. Toshiharu Ninomiya
Kyushu University

Toshiharu Ninomiya

Title

Dr.

Name

Toshiharu Ninomiya

Email

nino@intmed2.med.kyushu-u.ac.jp

Phone

092-642-6151

Institution

Kyushu University

Department

Faculty of Medical Sciences

Address

Fukuoka Japan
Dr. Jun Hata
Kyushu University

Jun Hata

Title

Dr.

Name

Jun Hata

Email

junhata@envmed.med.kyushu-u.ac.jp

Phone

092-642-6107

Institution

Kyushu University

Department

Faculty of Medical Sciences

Address

Fukuoka Japan
Dr. Tomoyuki Ohara
Kyushu University

Tomoyuki Ohara

Title

Dr.

Name

Tomoyuki Ohara

Phone

092-642-5627

Institution

Kyushu University

Department

Faculty of Medical Sciences

Address

Fukuoka Japan

Dr. Toshiharu Ninomiya
Kyushu University

Toshiharu Ninomiya

Title

Dr.

Name

Toshiharu Ninomiya

Email

nino@intmed2.med.kyushu-u.ac.jp

Phone

092-642-6151

Institution

Kyushu University

Department

Faculty of Medical Sciences

Address

Fukuoka Japan

Design

Study design

Cohort

Follow Up

The participants were followed up by repeated comprehensive health examinations every 2-3 years until 1974 and then every 5 years after that, in addition to usual annual health check-ups.

Comprehensive surveys of cognitive impairment in the elderly living in Hisayama town were also conducted every 6-7 years since 1985 (1985, 1992, 1998, 2005, and 2012).

Marker Paper

Ninomiya, T. Japanese Legacy Cohort Studies: The Hisayama Study. Journal of Epidemiology, 2018; 28(11): 444-451.

PUBMED 30298863

Recruitment

Recruitment Target

Individuals

Number of Participants

Number of Participants: 9,833
Number of Participants with Biological Samples: 9,833

Access

General Information

Availability of data and biosamples

Possible Access to Data
Possible Access to Biosamples
Other

Yes

Not applicable

Don't know

Timeline

Populations

Selection Criteria

Minimum age

Newborns

Twins

Countries

Japan

Territory

Hisayama, a suburb of the Fukuoka metropolitan area in the southern part of Japan

Ethnic Origin

Health Status

Recruitment

Sources of recruitment

General population

General Population

Volunteer enrolment

Number of Participants

Number of Participants: 1,658
Number of Participants with Biological Samples: 1,658

Data Collection Events

#	Name	Description	Start	End
0	HS - Cohort 1 - Comprehensive health check-up 1 HS - Cohort 1 - Comprehensive health check-up 1 Start Date 1961 End Date 1961 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. Each participant also completed a self-administered questionnaire ...	1961	1961
1	HS - Cohort 1 - early health check-ups HS - Cohort 1 - early health check-ups Start Date 1961 End Date 2014 Data sources Questionnaires Physical measures Administrative databases Other : Medical records, autopsy Files No files could be found.	Health check-ups were repeated annually. Vital and health status were checked annually by mail or telephone for any participants who did not undergo regular examination or who moved out of ...	1961	2014
2	HS - Cohort 1 - Comprehensive health check-up 2 HS - Cohort 1 - Comprehensive health check-up 2 Start Date 1963 End Date 1963 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	1963	1963
3	HS - Cohort 1 - Comprehensive health check-up 3 HS - Cohort 1 - Comprehensive health check-up 3 Start Date 1965 End Date 1965 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	1965	1965
4	HS - Cohort 1 - Comprehensive health check-up 4 HS - Cohort 1 - Comprehensive health check-up 4 Start Date 1967 End Date 1967 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	1967	1967
5	HS - Cohort 1 - Comprehensive health check-up 5 HS - Cohort 1 - Comprehensive health check-up 5 Start Date 1970 End Date 1970 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	1970	1970
6	HS - Cohort 1 - Comprehensive health check-up 6 HS - Cohort 1 - Comprehensive health check-up 6 Start Date 1973 End Date 1974 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	1973	1974
7	HS - Cohort 1 - Comprehensive health check-up 7 HS - Cohort 1 - Comprehensive health check-up 7 Start Date 1978 End Date 1978 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	1978	1978
8	HS - Cohort 1 - Comprehensive health check-up 8 HS - Cohort 1 - Comprehensive health check-up 8 Start Date 1983 End Date 1983 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	1983	1983
9	HS - Cohort 1 - Comprehensive surveys of cognitive impairment 1 HS - Cohort 1 - Comprehensive surveys of cognitive impairment 1 Start Date 1985 End Date 1985 Data sources Questionnaires Cognitive measures Files No files could be found.	Comprehensive surveys of cognitive function and impairment in the elderly population, including neuropsychological tests.	1985	1985
10	HS - Cohort 1 - Comprehensive health check-up 9 HS - Cohort 1 - Comprehensive health check-up 9 Start Date 1988 End Date 1988 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	1988	1988
11	HS - Cohort 1 - Comprehensive surveys of cognitive impairment 2 HS - Cohort 1 - Comprehensive surveys of cognitive impairment 2 Start Date 1992 End Date 1992 Data sources Questionnaires Cognitive measures Files No files could be found.	Comprehensive surveys of cognitive function and impairment in the elderly population, including neuropsychological tests.	1992	1992
12	HS - Cohort 1 - Comprehensive health check-up 10 HS - Cohort 1 - Comprehensive health check-up 10 Start Date 1993 End Date 1993 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	1993	1993
13	HS - Cohort 1 - Comprehensive health check-up 11 HS - Cohort 1 - Comprehensive health check-up 11 Start Date 1998 End Date 1998 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	1998	1998
14	HS - Cohort 1 - Comprehensive surveys of cognitive impairment 3 HS - Cohort 1 - Comprehensive surveys of cognitive impairment 3 Start Date 1998 End Date 1998 Data sources Questionnaires Cognitive measures Files No files could be found.	Comprehensive surveys of cognitive function and impairment in the elderly population, including neuropsychological tests.	1998	1998
15	HS - Cohort 1 - Comprehensive health check-up 12 HS - Cohort 1 - Comprehensive health check-up 12 Start Date 2002 End Date 2003 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	2002	2003
16	HS - Cohort 1 - Comprehensive surveys of cognitive impairment 4 HS - Cohort 1 - Comprehensive surveys of cognitive impairment 4 Start Date 2005 End Date 2005 Data sources Questionnaires Cognitive measures Files No files could be found.	Comprehensive surveys of cognitive function and impairment in the elderly population, including neuropsychological tests.	2005	2005
17	HS - Cohort 1 - Comprehensive health check-up 13 HS - Cohort 1 - Comprehensive health check-up 13 Start Date 2007 End Date 2008 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	2007	2008
18	HS - Cohort 1 - Comprehensive surveys of cognitive impairment 5 HS - Cohort 1 - Comprehensive surveys of cognitive impairment 5 Start Date 2012 End Date 2012 Data sources Questionnaires Cognitive measures Files No files could be found.	Comprehensive surveys of cognitive function and impairment in the elderly population, including neuropsychological tests.	2012	2012
19	HS - Cohort 1 - Comprehensive health check-up 14 HS - Cohort 1 - Comprehensive health check-up 14 Start Date 2012 End Date 2013 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	2012	2013

Selection Criteria

Minimum age

Newborns

Twins

Countries

Japan

Territory

Hisayama, a suburb of the Fukuoka metropolitan area in the southern part of Japan.

Ethnic Origin

Health Status

Recruitment

Sources of recruitment

General population

General Population

Volunteer enrolment

Number of Participants

Number of Participants: 2,135
Number of Participants with Biological Samples: 2,135

Data Collection Events

#	Name	Description	Start	End
0	HS - Cohort 2 - Comprehensive health check-up 6 HS - Cohort 2 - Comprehensive health check-up 6 Start Date 1973 End Date 1974 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	1973	1974
1	HS - Cohort 2 - Yearly health check-ups HS - Cohort 2 - Yearly health check-ups Start Date 1973 End Date 2014 Data sources Questionnaires Physical measures Administrative databases Other : Medical records, autopsy Files No files could be found.	Health check-ups were repeated annually. Vital and health status were checked annually by mail or telephone for any participants who did not undergo regular examination or who moved out of ...	1973	2014
2	HS - Cohort 2 - Comprehensive health check-up 7 HS - Cohort 2 - Comprehensive health check-up 7 Start Date 1978 End Date 1978 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	1978	1978
3	HS - Cohort 2 - Comprehensive health check-up 8 HS - Cohort 2 - Comprehensive health check-up 8 Start Date 1983 End Date 1983 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	1983	1983
4	HS - Cohort 2 - Comprehensive surveys of cognitive impairment 1 HS - Cohort 2 - Comprehensive surveys of cognitive impairment 1 Start Date 1985 End Date 1985 Data sources Questionnaires Cognitive measures Files No files could be found.	Comprehensive surveys of cognitive function and impairment in the elderly population, including neuropsychological tests.	1985	1985
5	HS - Cohort 2 - Comprehensive health check-up 9 HS - Cohort 2 - Comprehensive health check-up 9 Start Date 1988 End Date 1988 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	1988	1988
6	HS - Cohort 2 - Comprehensive surveys of cognitive impairment 2 HS - Cohort 2 - Comprehensive surveys of cognitive impairment 2 Start Date 1992 End Date 1992 Data sources Questionnaires Cognitive measures Files No files could be found.	Comprehensive surveys of cognitive function and impairment in the elderly population, including neuropsychological tests.	1992	1992
7	HS - Cohort 2 - Comprehensive health check-up 10 HS - Cohort 2 - Comprehensive health check-up 10 Start Date 1993 End Date 1993 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	1993	1993
8	HS - Cohort 2 - Comprehensive surveys of cognitive impairment 3 HS - Cohort 2 - Comprehensive surveys of cognitive impairment 3 Start Date 1998 End Date 1998 Data sources Questionnaires Cognitive measures Files No files could be found.	Comprehensive surveys of cognitive function and impairment in the elderly population, including neuropsychological tests.	1998	1998
9	HS - Cohort 2 - Comprehensive health check-up 11 HS - Cohort 2 - Comprehensive health check-up 11 Start Date 1998 End Date 1998 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	1998	1998
10	HS - Cohort 2 - Comprehensive health check-up 12 HS - Cohort 2 - Comprehensive health check-up 12 Start Date 2002 End Date 2003 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	2002	2003
11	HS - Cohort 2 - Comprehensive surveys of cognitive impairment 4 HS - Cohort 2 - Comprehensive surveys of cognitive impairment 4 Start Date 2005 End Date 2005 Data sources Questionnaires Cognitive measures Files No files could be found.	Comprehensive surveys of cognitive function and impairment in the elderly population, including neuropsychological tests.	2005	2005
12	HS - Cohort 2 - Comprehensive health check-up 13 HS - Cohort 2 - Comprehensive health check-up 13 Start Date 2007 End Date 2008 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	2007	2008
13	HS - Cohort 2 - Comprehensive surveys of cognitive impairment 5 HS - Cohort 2 - Comprehensive surveys of cognitive impairment 5 Start Date 2012 End Date 2012 Data sources Questionnaires Cognitive measures Files No files could be found.	Comprehensive surveys of cognitive function and impairment in the elderly population, including neuropsychological tests.	2012	2012
14	HS - Cohort 2 - Comprehensive health check-up 14 HS - Cohort 2 - Comprehensive health check-up 14 Start Date 2012 End Date 2013 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	2012	2013

Selection Criteria

Minimum age

Newborns

Twins

Countries

Japan

Territory

Hisayama, a suburb of the Fukuoka metropolitan area in the southern part of Japan.

Ethnic Origin

Health Status

Recruitment

Sources of recruitment

General population

General Population

Volunteer enrolment

Number of Participants

Number of Participants: 2,742
Number of Participants with Biological Samples: 2,742

Data Collection Events

#	Name	Description	Start	End
0	HS - Cohort 3 - Comprehensive health check-up 9 HS - Cohort 3 - Comprehensive health check-up 9 Start Date 1988 End Date 1988 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	1988	1988
1	HS - Cohort 3 - Yearly health check-ups HS - Cohort 3 - Yearly health check-ups Start Date 1988 End Date 2014 Data sources Questionnaires Physical measures Administrative databases Other : Medical records, autopsy Files No files could be found.	Health check-ups were repeated annually. Vital and health status were checked annually by mail or telephone for any participants who did not undergo regular examination or who moved out of ...	1988	2014
2	HS - Cohort 3 - Comprehensive surveys of cognitive impairment 2 HS - Cohort 3 - Comprehensive surveys of cognitive impairment 2 Start Date 1992 End Date 1992 Data sources Questionnaires Cognitive measures Files No files could be found.	Comprehensive surveys of cognitive function and impairment in the elderly population, including neuropsychological tests.	1992	1992
3	HS - Cohort 3 - Comprehensive health check-up 10 HS - Cohort 3 - Comprehensive health check-up 10 Start Date 1993 End Date 1993 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	1993	1993
4	HS - Cohort 3 - Comprehensive health check-up 11 HS - Cohort 3 - Comprehensive health check-up 11 Start Date 1998 End Date 1998 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	1998	1998
5	HS - Cohort 3 - Comprehensive surveys of cognitive impairment 3 HS - Cohort 3 - Comprehensive surveys of cognitive impairment 3 Start Date 1998 End Date 1998 Data sources Questionnaires Cognitive measures Files No files could be found.	Comprehensive surveys of cognitive function and impairment in the elderly population, including neuropsychological tests.	1998	1998
6	HS - Cohort 3 - Comprehensive health check-up 12 HS - Cohort 3 - Comprehensive health check-up 12 Start Date 2002 End Date 2003 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	2002	2003
7	HS - Cohort 3 - Comprehensive surveys of cognitive impairment 4 HS - Cohort 3 - Comprehensive surveys of cognitive impairment 4 Start Date 2005 End Date 2005 Data sources Questionnaires Cognitive measures Files No files could be found.	Comprehensive surveys of cognitive function and impairment in the elderly population, including neuropsychological tests.	2005	2005
8	HS - Cohort 3 - Comprehensive health check-up 13 HS - Cohort 3 - Comprehensive health check-up 13 Start Date 2007 End Date 2008 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	2007	2008
9	HS - Cohort 3 - Comprehensive surveys of cognitive impairment 5 HS - Cohort 3 - Comprehensive surveys of cognitive impairment 5 Start Date 2012 End Date 2012 Data sources Questionnaires Cognitive measures Files No files could be found.	Comprehensive surveys of cognitive function and impairment in the elderly population, including neuropsychological tests.	2012	2012
10	HS - Cohort 3 - Comprehensive health check-up 14 HS - Cohort 3 - Comprehensive health check-up 14 Start Date 2012 End Date 2013 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	2012	2013

Selection Criteria

Minimum age

Newborns

Twins

Countries

Japan

Territory

Hisayama, a suburb of the Fukuoka metropolitan area in the southern part of Japan.

Ethnic Origin

Health Status

Recruitment

Sources of recruitment

General population

General Population

Volunteer enrolment

Number of Participants

Number of Participants: 3,298
Number of Participants with Biological Samples: 3,298

Data Collection Events

#	Name	Description	Start	End
0	HS - Cohort 4 - Comprehensive health check-up 12 HS - Cohort 4 - Comprehensive health check-up 12 Start Date 2002 End Date 2003 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	2002	2003
1	HS - Cohort 4 - Yearly health check-ups HS - Cohort 4 - Yearly health check-ups Start Date 2002 End Date 2014 Data sources Questionnaires Physical measures Administrative databases Other : Medical records, autopsy Files No files could be found.	Health check-ups were repeated annually. Vital and health status were checked annually by mail or telephone for any participants who did not undergo regular examination or who moved out of ...	2002	2014
2	HS - Cohort 4 - Comprehensive surveys of cognitive impairment 4 HS - Cohort 4 - Comprehensive surveys of cognitive impairment 4 Start Date 2005 End Date 2005 Data sources Questionnaires Cognitive measures Files No files could be found.	Comprehensive surveys of cognitive function and impairment in the elderly population, including neuropsychological tests.	2005	2005
3	HS - Cohort 4 - Comprehensive health check-up 13 HS - Cohort 4 - Comprehensive health check-up 13 Start Date 2007 End Date 2008 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	2007	2008
4	HS - Cohort 4 - Comprehensive surveys of cognitive impairment 5 HS - Cohort 4 - Comprehensive surveys of cognitive impairment 5 Start Date 2012 End Date 2012 Data sources Questionnaires Cognitive measures Files No files could be found.	Comprehensive surveys of cognitive function and impairment in the elderly population, including neuropsychological tests.	2012	2012
5	HS - Cohort 4 - Comprehensive health check-up 14 HS - Cohort 4 - Comprehensive health check-up 14 Start Date 2012 End Date 2013 Data sources Questionnaires Physical measures Biosamples Data sources - Biosamples Blood Files No files could be found.	The participants received full check-ups on their health status and neurological condition. When new neurological symptoms were suspected, study team physicians evaluated the ...	2012	2013

Classifications

Socio-demographic and economic characteristics
Lifestyle and behaviours
Birth, pregnancy and reproductive health history
Perception of health, quality of life, development and functional limitations
Diseases
Symptoms and signs
Medication and supplements
Non-pharmacological interventions
Health and community care services utilization
Death
Physical measures and assessments
Laboratory measures
Cognition, personality and psychological measures and assessments
Life events, life plans, beliefs and values
Preschool, school and work life
Social environment and relationships
Physical environment
Administrative information

Socio-demographic and economic characteristics

Age/birthdate

Sex/gender

Education

Lifestyle and behaviours

Tobacco

Alcohol

Physical activity

Diseases

Endocrine, nutritional and metabolic diseases (E00-E90)

Mental and behavioural disorders (F00-F99)

Diseases of the nervous system (G00-G99)

Diseases of the circulatory system (I00-I99)

Diseases of the genitourinary system (N00-N99)

Diseases without precise specification or falling into multiple categories

Medication and supplements

Medication and supplement intake

Death

Vital status

Other end of life or death-related information

Physical measures and assessments

Anthropometry

Circulation and respiration

Laboratory measures

Hematology

Biochemistry

Genomics

Individual Study / HS

Hisayama Study

Members

Design

Marker Paper

Recruitment

Number of Participants

Access

Timeline

Populations

Selection Criteria

Recruitment

Number of Participants

Files

Data Collection Events

Selection Criteria

Recruitment

Number of Participants

Files

Data Collection Events

Selection Criteria

Recruitment

Number of Participants

Files

Data Collection Events

Selection Criteria

Recruitment

Number of Participants

Files

Data Collection Events

Files

Classifications

Variables Classifications

Individual Study / HS

Hisayama Study

Members

Yutaka Kiyohara

Toshiharu Ninomiya

Jun Hata

Tomoyuki Ohara

Toshiharu Ninomiya

Design

Marker Paper

Recruitment

Number of Participants

Access

Timeline

Populations

Selection Criteria

Recruitment

Number of Participants

Files

Data Collection Events

HS - Cohort 1 - Comprehensive health check-up 1

HS - Cohort 1 - early health check-ups

HS - Cohort 1 - Comprehensive health check-up 2

HS - Cohort 1 - Comprehensive health check-up 3

HS - Cohort 1 - Comprehensive health check-up 4

HS - Cohort 1 - Comprehensive health check-up 5

HS - Cohort 1 - Comprehensive health check-up 6

HS - Cohort 1 - Comprehensive health check-up 7

HS - Cohort 1 - Comprehensive health check-up 8

HS - Cohort 1 - Comprehensive surveys of cognitive impairment 1

HS - Cohort 1 - Comprehensive health check-up 9

HS - Cohort 1 - Comprehensive surveys of cognitive impairment 2

HS - Cohort 1 - Comprehensive health check-up 10

HS - Cohort 1 - Comprehensive health check-up 11

HS - Cohort 1 - Comprehensive surveys of cognitive impairment 3

HS - Cohort 1 - Comprehensive health check-up 12

HS - Cohort 1 - Comprehensive surveys of cognitive impairment 4

HS - Cohort 1 - Comprehensive health check-up 13

HS - Cohort 1 - Comprehensive surveys of cognitive impairment 5

HS - Cohort 1 - Comprehensive health check-up 14

Selection Criteria

Recruitment

Number of Participants

Files

Data Collection Events

HS - Cohort 2 - Comprehensive health check-up 6

HS - Cohort 2 - Yearly health check-ups

HS - Cohort 2 - Comprehensive health check-up 7

HS - Cohort 2 - Comprehensive health check-up 8

HS - Cohort 2 - Comprehensive surveys of cognitive impairment 1

HS - Cohort 2 - Comprehensive health check-up 9

HS - Cohort 2 - Comprehensive surveys of cognitive impairment 2

HS - Cohort 2 - Comprehensive health check-up 10

HS - Cohort 2 - Comprehensive surveys of cognitive impairment 3

HS - Cohort 2 - Comprehensive health check-up 11

HS - Cohort 2 - Comprehensive health check-up 12

HS - Cohort 2 - Comprehensive surveys of cognitive impairment 4

HS - Cohort 2 - Comprehensive health check-up 13

HS - Cohort 2 - Comprehensive surveys of cognitive impairment 5

HS - Cohort 2 - Comprehensive health check-up 14

Selection Criteria

Recruitment

Number of Participants

Files

Data Collection Events

HS - Cohort 3 - Comprehensive health check-up 9

HS - Cohort 3 - Yearly health check-ups

HS - Cohort 3 - Comprehensive surveys of cognitive impairment 2

HS - Cohort 3 - Comprehensive health check-up 10

HS - Cohort 3 - Comprehensive health check-up 11

HS - Cohort 3 - Comprehensive surveys of cognitive impairment 3

HS - Cohort 3 - Comprehensive health check-up 12

HS - Cohort 3 - Comprehensive surveys of cognitive impairment 4

HS - Cohort 3 - Comprehensive health check-up 13

HS - Cohort 3 - Comprehensive surveys of cognitive impairment 5

HS - Cohort 3 - Comprehensive health check-up 14

Selection Criteria

Recruitment

Number of Participants

Files