Hellenic Longitudinal Investigation of Aging and Diet
The main objectives of the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD) are to investigate in the Greek population, associations between the Mediterranean-type diet and cognitive dysfunction/age-related neuropsychiatric diseases, and to estimate the prevalence and incidence of Alzheimer’s disease, other dementias, mild cognitive impairment, and other neuropsychiatric conditions of aging.
The study also ascertains several demographic, medical, social, environmental, clinical, nutritional, and neuropsychological determinants and lifestyle activities.
- Start Year
- 2011
Visit HELIAD
| Investigators | Contacts |
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Design
- Study design
- Cohort
- Follow Up
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Follow-ups with face-to-face interviews at 3 year intervals.
- Supplementary Information
Marker Paper
Dardiotis et al. The Hellenic Longitudinal Investigation of Aging and Diet (HELIAD): Rationale, study design, and cohort description. Neuroepidemiology, 2014;43:9-14.
PUBMED 24993387
Recruitment
- Recruitment Target
-
- Individuals
Number of Participants
- Number of Participants
- 1,943
- Number of Participants with Biological Samples
- 1,386
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Timeline
HELIAD - Population
Selection Criteria
- Minimum age
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65
- Newborns
- Twins
- Countries
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- Greece
- Territory
- Larissa and Marousi
- Ethnic Origin
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- Health Status
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- Supplementary Information about selection criteria
- The study is conducted in Larissa , Thessaly, since 2009, and in Marousi, Athens, since 2013.
Recruitment
- Sources of recruitment
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- General population
- General Population
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- Selected sample
Number of Participants
- Number of Participants
- 1,943
- Number of Participants with Biological Samples
- 1,386
Data Collection Event
Certified neurologists, trained neuropsychologists and dieticians administered structured questionnaires in face-to-face interviews and conducted neuropsychological assessments of participants.
Questionnaires collected socio-demographic information including a detailed medical and family history. The study participants were interviewed regarding their involvement in common leisure time activities including social, mental, and physical ones. Change in performance of daily activities and self-care habits that require physical capacity and cognitive functioning were recorded. The participants were also queried in detail about their basic physical abilities and about quantitative and qualitative features of sleep during the last month. Dietary intake was evaluated through a semi-qualitative Food Frequency Questionnaire (FFQ) developed and validated for the Greek population.
The participants were screened for neuro-psychiatric conditions including depression, anxiety, and psychotic symptoms. In addition, neurologists carried out a complete and structured neurological evaluation and trained psychometricians administered a complete battery of neuropsychological test assessing all major cognitive domains.
Physical strength of the upper extremities was estimated using a handgrip electronic dynamometer.
Nonfasting blood samples were collected.
- Start Date
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2011
- End Date
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2016
- Data sources
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- Questionnaires
- Cognitive measures
- Physical measures
- Biosamples
- Data sources - Biosamples
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- Blood
- Other : DNA
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
- Cognitive functioning
- Personality
- Psychological distress and emotions
- Other psychological measures and assessments
- Perception of health
- Quality of life
- Life course development
- Functional limitations
- Other perception of health, quality of life and functional limitation-related information
- Tobacco
- Alcohol
- Drugs
- Nutrition
- Breastfeeding
- Physical activity
- Sleep
- Sexual behaviours and orientation
- Technological devices
- Misbehaviour and criminality
- Other and unspecified lifestyle information
Socio-demographic and economic characteristics
Lifestyle and behaviours
Birth, pregnancy and reproductive health history
Perception of health, quality of life, development and functional limitations
Diseases
Symptoms and signs
Medication and supplements
Non-pharmacological interventions
Health and community care services utilization
Death
Physical measures and assessments
Laboratory measures
Cognition, personality and psychological measures and assessments
Social environment and relationships
Physical environment
Administrative information
Cognitive functioning
Psychological distress and emotions
Functional limitations
Nutrition
Physical activity
Sleep