GESTation and Environment
The initial objective of this study was to investigate the association between maternal blood PBDE concentrations measured in early pregnancy and serum thyroid hormone levels assessed at less than 20 weeks of pregnancy, at delivery, and in cord blood.
More specifically the study aimed to:
- examine the relationship between PBDE concentrations and thyroid hormones and their metabolites in maternal and cord blood;
- determine the dose-response relationship between Mn, Cd, Pb, PCB, PBDE and Hg concentrations at birth, and psychomotor scores of children taking into account potential confounding factors including postnatal exposures;
- determine whether prenatal exposure to PBDE flame retardants is associated with MRI abnormalities in brain function and connectivity and with ADHD behaviors and diagnosis;
- determine whether prenatal exposure to halogenated non-PBDE flame retardants is associated with MRI abnormalities in brain function and connectivity and with ADHD behaviors and diagnosis; and
- explore whether the levels of PBDEs and their substitutes, measured in both blood and stools during childhood, are associated with MRI brain measures, neurobehaviors and ADHD diagnosis, directly or via alterations of the gut microbiome.
- Start Year
- 2007
- Supplementary Information
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Serme-Gbedo YK, Abdelouahab N, Pasquier JC, Cohen AA, Takser L. Maternal levels of endocrine disruptors, polybrominated diphenyl ethers, in early pregnancy are not associated with lower birth weight in the Canadian birth cohort GESTE. Environ Health. 2016 Apr 12;15:49.
PMID: 27068391
Visit GESTE
| Investigators | Contacts |
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Design
- Study design
- Cohort
- Follow Up
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Women were enrolled at less than 20 weeks of pregnancy, at their first prenatal care visit, with follow-up at delivery. Other women were recruited at delivery. All children were then followed at 2 years, 6-7 years and at 8-12 years.
- Supplementary Information
Marker Paper
Abdelouahab N, Langlois MF, Lavoie L, Corbin F, Pasquier JC, Takser L. 2013. Maternal and cord-blood thyroid hormone levels and exposure to polybrominated diphenyl ethers and polychlorinated biphenyls during early pregnancy. AJE (2013) 178(5):701-713.
PUBMED 23924579
Recruitment
- Recruitment Target
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- Families
Number of Participants
- Number of Participants
- 1,561
- Number of Participants with Biological Samples
- 1,561
- Supplementary Information
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Mothers: 800 participants
Children: 761 participants
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Timeline
Populations
Selection Criteria
- Sex
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Women
- Minimum age
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18
- Pregnant Women
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- First trimester
- Second trimester
- Newborns
- Twins
- Countries
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- Canada
- Territory
- Sherbrooke
- Ethnic Origin
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- Health Status
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- No known thyroid disease
- Other Criteria
- Gestational age less than 20 weeks or at delivery.
- Supplementary Information about selection criteria
- After verification of medical files, a post hoc exclusion criterion was added: use of medication known to affect thyroid hormone levels.
Recruitment
- Sources of recruitment
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- Specific population
- Specific Population
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- Clinic patients
- Supplementary Information
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Participants were recruited at their first care visit. A second sample of women was recruited at delivery.
Number of Participants
- Number of Participants
- 800
- Number of Participants with Biological Samples
- 800
- Supplementary Information about selection criteria
-
20 weeks gestation: 400 participants
Delivery: 761 participants
6-7 years: 367 participants
8-12 years: 161 participants (ongoing)
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
GESTE - Mothers - < 20 weeks gestation
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Sociodemographic information was collected using an interview-administered questionnaire, including information on age, education, income, alcohol consumption, smoking, drug use, occupational ... |
2007-09 | 2008-12 |
| 1 |
GESTE - Mothers - Delivery
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A questionnaire collected information about medical and obstetrical history and smoking and drinking during pregnancy. Height and weight were measured by a nurse and used to calculate ... |
2008-02 | 2009-07 |
| 2 |
GESTE - Mothers - Follow-up at 6-7 years
|
At the 6-7 years follow-up, sociodemographic information was collected using an interview-administered questionnaire, including information on age, education, income, alcohol consumption, ... |
2014-07 | 2016-11 |
| 3 |
GESTE - Mothers - Follow-up at 8-12 years
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At the 8-10 years follow-up, sociodemographic information was collected using an interview-administered questionnaire, including information on age, education, income, alcohol consumption, ... |
2017-09 | 2023-03 |
Selection Criteria
- Newborns
- Twins
- Countries
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- Canada
- Territory
- Sherbrooke
- Ethnic Origin
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- Health Status
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Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
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- Other specific population : Children of the women in the GESTE study.
Number of Participants
- Number of Participants
- 761
- Number of Participants with Biological Samples
- 761
- Supplementary Information about selection criteria
-
Delivery: 761 participants
2 years: 291 participants
6-7 years: 367 participants
8-12 years: 161 participants (ongoing)
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
GESTE - Children - Delivery
|
At delivery, lenght and weight were measured by a nurse. Apgar score and other complications were also collected. Umbilical-cord blood was collected for analysis of PBDEs, PCBs, lipids ... |
2008-02 | 2009-07 |
| 1 |
GESTE - Children - Follow-up at 2 years old
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At the 2 years follow-up, information about sociodemographics, nutrition (including breastfeeding and formula use), and anthropometric measurements was collected by questionnaire. Information ... |
2010-02 | 2011-07 |
| 2 |
GESTE - Children - Follow-up at 6-7 years old
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At the 6-7 years follow-up, cognitive function was assessed using the Wechsler Intelligence Scale for Children (WISC-IV), the Developmental NEuroPSYchological Assessment (NEPSY-II), the Test of ... |
2014-07 | 2016-11 |
| 3 |
GESTE - Children - Follow-up at 8-12 years old
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At the 8-10 years follow-up, information was collected using an interview-administered questionnaire to the parents including information on nutrition using a Food Frequency Questionnaire ... |
2017-09 | 2023-03 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
- Cognitive functioning
- Personality
- Psychological distress and emotions
- Other psychological measures and assessments
- Perception of health
- Quality of life
- Life course development
- Functional limitations
- Other perception of health, quality of life and functional limitation-related information
- Tobacco
- Alcohol
- Drugs
- Nutrition
- Breastfeeding
- Physical activity
- Sleep
- Sexual behaviours and orientation
- Technological devices
- Misbehaviour and criminality
- Other and unspecified lifestyle information
Socio-demographic and economic characteristics
Lifestyle and behaviours
Birth, pregnancy and reproductive health history
Perception of health, quality of life, development and functional limitations
Diseases
Symptoms and signs
Medication and supplements
Health and community care services utilization
Physical measures and assessments
Laboratory measures
Cognition, personality and psychological measures and assessments
Life events, life plans, beliefs and values
Preschool, school and work life
Physical environment
Administrative information
Cognitive functioning
Personality
Psychological distress and emotions
Life course development
Nutrition