Genetics of Glucose regulation in Gestation and Growth
- Start Year
- 2010
| Investigators | Contacts |
|---|---|
|
|
Design
- Study design
- Cohort
- Follow Up
- Data and samples were collected at two time points during pregnancy and at delivery. The first research visit was between 5 and 16 weeks of gestation and the second visit was planned between 24 and 30 weeks. The follow-up of mothers and children 3-5 years postpartum is in process.
- Supplementary Information
Marker Paper
Guillemette L, Allard C, Lacroix M, Patenaude J, Battista MC, Doyon M, Moreau J, Ménard J, Bouchard L, Ardilouze JL, Perron P, Hivert MF. Genetics of Glucose regulation in Gestation and Growth (Gen3G): a prospective prebirth cohort of mother-child pairs in Sherbrooke, Canada. BMJ Open. 2016 Feb 3;6(2):e010031.
PUBMED 26842272
Recruitment
- Recruitment Target
-
- Families
Number of Participants
- Number of Participants
- 1,888
- Number of Participants with Biological Samples
- 1,300
- Supplementary Information
-
Mothers: 1,034 participants
Children: 854 participants
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Availability of access information
By contacting the study representative
Sector of research
| Possible Access to Data | Possible Access to Biosamples | |
|---|---|---|
| Investigators from the public sector | ||
| Investigators from the private sector | ||
| Investigators from not-for-profit organization |
Transfer
| Possible Access to Data | Possible Access to Biosamples | |
|---|---|---|
| Can leave the study facility | ||
| Can leave the country |
no personal identification, protected transfer of data, protocol IRB approved by receiving institution, financial support as required, DTA/MTA is also required before any transfer
Cost
| Possible Access to Data | Variable Cost |
| Possible Access to Biosamples | Variable Cost |
cost depends on extent of work to prepare dataset, and/or samples handling
Cost reduction for co-analyses
| Possible Access to Data | |
| Possible Access to Biosamples |
Timeline
Populations
Selection Criteria
- Sex
-
Women
- Minimum age
-
18
- Pregnant Women
-
- First trimester
- Newborns
- Twins
- Countries
-
- Canada
- Territory
- Eastern Townships region
- Ethnic Origin
-
- Health Status
-
- Other Criteria
- Women were excluded if they: had known pre-pregnancy diabetes, took medication that influenced glucose tolerance, had glycated haemoglobin (HbA1c) ≥6.5% or 1 h glucose ≥10.3 mmol/L post-50 g GCT, as this was classified as overt diabetes based on 2008 CDA criteria.
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
-
- Clinic patients
- Supplementary Information
-
All women were invited to participate if they received prenatal care directly at or in a health center affiliated with the CHUS and planned delivery at the CHUS.
Number of Participants
- Number of Participants
- 1,034
- Number of Participants with Biological Samples
- 696
- Supplementary Information about selection criteria
-
First trimester: 1034 participants
Second trimester: 898 participants
Delivery: 854 participants
3 years follow-up: 448 mother-child dyads
5 years follow-up: 521 mother-child dyads
12 years follow: 430 mother-child dyads and still ongoing
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
Gen3G - Mothers - First trimester
|
The first research visit (V1) was between 5 and 16 weeks of gestation, coinciding with women’s first trimester prenatal clinical blood sampling as requested by their primary care physician. ... |
2010-01 | 2013-06 |
| 1 |
Gen3G - Mothers - Second trimester
|
The second visit (V2) was planned between 24 and 30 weeks, concomitantly with clinically indicated GDM screening test. During this visit, the medical history was updated, anthropometric ... |
2010-05 | 2013-10 |
| 2 |
Gen3G - Mothers - Delivery
|
Research in obstetric services offered trained research staff on call 24 h per day, 7 days per week and were directly contacted by clinical nurses from the obstetric department each time a ... |
2010-08 | 2014-01 |
| 3 |
Gen3G - Mothers 3 years post delivery
|
During this visit, we met mother-child dyad. We collected updates medical history, and collected socio-demographic data, lifestyle habits and anthropometric measurements (weight, waist ... | 2013-08 | 2017-03 |
| 4 |
Gen3G - Mothers 5 years post delivery
|
During this visit, we met mother-child dyad. We collected socio-demographic data, medical histories updated, lifestyle habits, anthropometric measurements (weight, waist circumference). If ... | 2015-06 | 2019-03 |
| 5 |
Gen3G - Mothers 12 years post delivery
|
The 12 years after delivery included up to 2 visits, where we met mother-child dyads. During the first visit, we collected socio-demographic data, medical histories updated, lifestyle habits, ... | 2021-08 | 2025-12 |
Selection Criteria
- Newborns
- Twins
- Countries
-
- Canada
- Territory
- Eastern Townships region
- Ethnic Origin
-
- Health Status
-
- Other Criteria
- Supplementary Information about selection criteria
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
-
- Other specific population : Children of the women in Gen3G study
Number of Participants
- Number of Participants
- 854
- Number of Participants with Biological Samples
- 604
- Supplementary Information about selection criteria
- N=662 cord blood samples N= 694 placenta samples
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
Gen3G - Children - Delivery
|
Research in obstetric services offered trained research staff on call 24 h per day, 7 days per week and were directly contacted by clinical nurses from the obstetric department each time a ... |
2010-08 | 2014-01 |
| 1 |
Gen3G - Children – 3 years post delivery
|
During this visit, we met mother-child dyad. We updated medical history and collected lifestyle habits, anthropometric measurements (height, weight, waist and hip circumferences, skinfolds), and ... | 2013-08 | 2017-03 |
| 2 |
Gen3G - Children – 5 years post delivery
|
During this visit, we met mother-child dyad. We updated medical history and collected lifestyle habits, anthropometric measurements (height, weight, waist and hip circumferences, skinfolds), and ... | 2015-06 | 2019-03 |
| 3 |
Gen3G - Children – 12 years post delivery
|
The 12 years after delivery included up to 2 visits, where we met mother-child dyads. During the first visit, we updated medical history and collected lifestyle habits, anthropometric ... | 2021-08 | 2025-12 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
- Cognitive functioning
- Personality
- Psychological distress and emotions
- Other psychological measures and assessments
- Tobacco
- Alcohol
- Drugs
- Nutrition
- Breastfeeding
- Physical activity
- Sleep
- Sexual behaviours and orientation
- Technological devices
- Misbehaviour and criminality
- Other and unspecified lifestyle information
Socio-demographic and economic characteristics
Lifestyle and behaviours
Birth, pregnancy and reproductive health history
Perception of health, quality of life, development and functional limitations
Diseases
Symptoms and signs
Medication and supplements
Non-pharmacological interventions
Health and community care services utilization
Death
Physical measures and assessments
Laboratory measures
Cognition, personality and psychological measures and assessments
Preschool, school and work life
Social environment and relationships
Physical environment
Administrative information
Cognitive functioning
Personality
Psychological distress and emotions
Nutrition