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Epidemiology of Dementia in Central Africa
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Epidemiology of Dementia in Central Africa

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Datasets -
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Start Year
2011
End Year
2015
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Investigators Contacts
  • Pr. Pierre-Marie Preux
    Université de Limoges
  • Dr. Maelenn Guerchet
    Universite de Limoges
  • Dr. Maelenn Guerchet
    Universite de Limoges

Design

Study design
Cohort
Follow Up
Participants from the Central African Republic and the Congo were first assessed in the cross-sectional two-phase surveys making up EPIDEMCA. Participants in Congo were followed-up annually between 2012 and 2015 (EPIDEMCA-FU).

Marker Paper

Guerchet M., Mbelesso P., Ndamba-Bandzouzi B., Pilleron, S., Desormais, I., Lacroix, P., Aboyans, V., Jésus, P., Desport, J-C, Tchalla, A.E., Marin, B., Lambert, J-C, Clément, J-P, Dartigues, J-F, Preux, P-M and for the EPIDEMCA group. Epidemiology of dementia in Central Africa (EPIDEMCA): protocol for a multicentre population-based study in rural and urban areas of the Central African Republic and the Republic of Congo. Springerplus. 2014;3:338

PUBMED 25045613

Recruitment

Recruitment Target
  • Individuals

Number of Participants

Number of Participants
2,002
Number of Participants with Biological Samples
1,662
Supplementary Information
EPIDEMCA follow-up: 1029 participants

Access

Availability of data and biosamples

Possible Access to Data
Possible Access to Biosamples
Other
Yes
No
Not applicable
Don't know

Timeline

Populations

Selection Criteria
Minimum age
65
Newborns
Twins
Countries
  • Central African Republic
Territory
Nola (Sangha-Mbaéré region)
Ethnic Origin
Health Status
  • Exclusion criteria: The presence of severe disease with short-term high risk of death.
Supplementary Information about selection criteria

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample
Supplementary Information
Samples were obtained through a door-to-door knocking carried out in each district constituting the rural catchment area (Nola and villages in a 10km radius).

Number of Participants

Number of Participants
473
Number of Participants with Biological Samples
388
Supplementary Information about selection criteria
P1: 473 Participants
P2: 117 Participants
Data Collection Events
# Name Description Start End
0 EPIDEMCA - Nola - P1

The first phase was conducted in the participant or their relative’s homes.

Information about marital status, living circumstances, current and past occupation, education, literacy, and ...

 2011-11 2011-12
1 EPIDEMCA - Nola - P2

This second phase was conducted between 3 and 14 weeks after P1, at the closest hospital or community health centre, by neurologists and for participants who obtained a poor performance to the ...

 2012-02 2012-03
Selection Criteria
Minimum age
65
Newborns
Twins
Countries
  • Central African Republic
Territory
Bangui
Ethnic Origin
Health Status
  • Exclusion criteria: The presence of severe disease with short-term high risk of death.
Supplementary Information about selection criteria

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample
Supplementary Information
A random sampling proportional to the size of each main subdivision of the city was realized in order to be representative of Bangui’s diverse population.

Number of Participants

Number of Participants
500
Number of Participants with Biological Samples
439
Supplementary Information about selection criteria
P1: 500 Participants
P2: 115 Participants
Data Collection Events
# Name Description Start End
0 EPIDEMCA - Bangui - P1

The first phase was conducted in the participant or their relative’s homes.

Information was collected about marital status, living circumstances, current and past occupation, education, ...

 2012-01 2012-02
1 EPIDEMCA - Bangui - P2

This second phase was conducted between 3 and 14 weeks after P1, at the closest hospital or community health centre, by neurologists and for participants who obtained a poor performance to the ...

 2012-02 2012-03
Selection Criteria
Minimum age
65
Newborns
Twins
Countries
  • Congo
Territory
Gamboma (Plateaux region)
Ethnic Origin
Health Status
  • Exclusion criteria: The presence of severe disease with short-term high risk of death.
Supplementary Information about selection criteria

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample
Supplementary Information
Samples were obtained through a door-to-door knocking carried out in each district constituting the rural catchment area (Gamboma’s main districts).

Number of Participants

Number of Participants
529
Number of Participants with Biological Samples
427
Supplementary Information about selection criteria
P1: 529 Participants
P2: 193 Participants
F1: 325 Participants
F2: 200 Participants
Data Collection Events
# Name Description Start End
0 EPIDEMCA - Gamboma - P1

The first phase was conducted in the participant or their relative’s homes.

Information concerning marital status, living circumstances, current and past occupation, education, ...

 2012-08 2012-09
1 EPIDEMCA - Gamboma - P2

This second phase was conducted between 3 and 14 weeks after P1, at the closest hospital or community health centre, by neurologists and for participants who obtained a poor performance to the ...

 2012-11 2012-12
2 EPIDEMCA - Gamboma - F1

At each follow-up, an oral interview using a standardized questionnaire was conducted in participant’s homes. Vital status was recorded, in case of death the date was recorded and a verbal ...

 2013-07 2013-08
3 EPIDEMCA - Gamboma - F2

At each follow-up, an oral interview using a standardized questionnaire was conducted in participant’s homes. Vital status was recorded, in case of death the date was recorded and a verbal ...

 2014-07 2014-08
Selection Criteria
Minimum age
65
Newborns
Twins
Countries
  • Congo
Territory
Brazzaville
Ethnic Origin
Health Status
  • Exclusion criteria: The presence of severe disease with short-term high risk of death.
Supplementary Information about selection criteria

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample
Supplementary Information
A random sampling proportional to the size of each main subdivision of the city was realized in order to be representative of Brazzaville’s diverse population.

Number of Participants

Number of Participants
500
Number of Participants with Biological Samples
408
Supplementary Information about selection criteria
P1: 500 Participants
P2: 131 Participants
F1: 335 Participants
F2: 276 Participants
F3: 250 Participants
Data Collection Events
# Name Description Start End
0 EPIDEMCA - Brazzaville - P1

The first phase was conducted in the participant or their relative’s homes.

Information about marital status, living circumstances, current and past occupation, education, literacy, and ...

 2012-09 2012-10
1 EPIDEMCA - Brazzaville - P2

This second phase was conducted between 3 and 14 weeks after P1, at the closest hospital or community health centre, by neurologists and for participants who obtained a poor performance to the ...

 2012-11 2012-12
2 EPIDEMCA - Brazzaville - F1

At each follow-up, an oral interview using a standardized questionnaire was conducted in participant’s homes. Vital status was recorded, in case of death the date was recorded and a verbal ...

 2013-08 2013-09
3 EPIDEMCA - Brazzaville - F2

At each follow-up, an oral interview using a standardized questionnaire was conducted in participant’s homes. Vital status was recorded, in case of death the date was recorded and a verbal ...

 2014-08 2014-09
4 EPIDEMCA - Brazzaville - F3

At each follow-up, an oral interview using a standardized questionnaire was conducted in participant’s homes. Vital status was recorded, in case of death the date was recorded and a verbal ...

 2015-08 2015-09

Classifications

Socio-demographic and economic characteristics
Lifestyle and behaviours
Birth, pregnancy and reproductive health history
Perception of health, quality of life, development and functional limitations
Diseases
Symptoms and signs
Medication and supplements
Non-pharmacological interventions
Health and community care services utilization
Death
Physical measures and assessments
Laboratory measures
Cognition, personality and psychological measures and assessments
Life events, life plans, beliefs and values
Preschool, school and work life
Social environment and relationships
Physical environment
Administrative information
Cognitive functioning
Personality
Psychological distress and emotions
Other psychological measures and assessments
Perception of health
Quality of life
Life course development
Functional limitations
Other perception of health, quality of life and functional limitation-related information

Socio-demographic and economic characteristics

Age/birthdate
Sex/gender
Marital/partner status
Family and household structure
Education
Residence
Ethnicity, race and religion
Language
Labour force and retirement
Income, possessions, and benefits

Lifestyle and behaviours

Tobacco
Alcohol
Nutrition
Physical activity
Leisure activities

Perception of health, quality of life, development and functional limitations

Perception of health
Quality of life
Functional limitations
Use of assistive devices

Diseases

Certain infectious and parasitic diseases (A00-B99)
Neoplasms (C00-D48)
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
Endocrine, nutritional and metabolic diseases (E00-E90)
Mental and behavioural disorders (F00-F99)
Diseases of the nervous system (G00-G99)
Diseases of the eye and adnexa (H00-H59)
Diseases of the ear and mastoid process (H60-H95)
Diseases of the circulatory system (I00-I99)
Diseases of the respiratory system (J00-J99)
Diseases of the digestive system (K00-K93)
Diseases of the genitourinary system (N00-N99)
Injury, poisoning and certain other consequences of external causes (S00-T98)
Diseases without precise specification or falling into multiple categories

Symptoms and signs

Symptoms and signs involving nervous and musculoskeletal systems (R25-R29)
Symptoms and signs involving the urinary system (R30-R39)
Symptoms and signs involving cognition, perception, emotional state and behaviour (R40-R46)
Symptoms and signs involving speech and voice (R47-R49)
General symptoms and signs (R50-R69)

Medication and supplements

Medication and supplement intake

Non-pharmacological interventions

Other and unspecified non-pharmacological interventions

Health and community care services utilization

Visits to health professionals
Hospitalizations

Death

Vital status

Physical measures and assessments

Physical characteristics
Anthropometry
Circulation and respiration
Muscles, skeleton and mobility
Sensory and pain
Skin and subcutaneous tissue

Laboratory measures

Biochemistry
Immunology
Genomics

Cognition, personality and psychological measures and assessments

Cognitive functioning
Personality
Psychological distress and emotions

Life events, life plans, beliefs and values

Life events

Social environment and relationships

Social network
Social participation
Parenting and familial environment

Administrative information

Identifiers
Date and time-related information
Questionnaire and interview-related information
Physical and cognitive measure and biosample-related information
Data and sample collection center-related information
Other administrative information

Cognitive functioning

Clinical Dementia Rating Scale
Community Screening Instrument for Dementia
Digit Cancellation Test
Free and Cued Selective Reminding Test
Geriatric Mental State Examination
Questionnaire de Plainte Cognitive
Verbal Fluency

Personality

Personality Diagnostic Questionnaire

Psychological distress and emotions

Center for Epidemiological Studies Depression Scale
Geriatric Depression Scale
Neuropsychiatric Inventory

Quality of life

National Eye Institute Visual Function Questionnaire

Functional limitations

Central Africa Daily Functioning Interference Scale
Study of Osteoporotic Fractures Index