Determining Infection Severity of CoV-2 in Elderly Residents
Networks
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Datasets
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Variables
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The overall objective of this study is to use interferon-based immunological markers to optimize risk stratification for SARS-CoV-2 infected elderly residents of long-term care facilities. Secondary objectives are to focus on identifying clinical, biochemical and psychosocial determinants of COVID-19 severity and their association with interferon markers.
The goals of the DISCoVER biobank are to:
* Collect blood samples to look at molecules in the immune system to determine if they are important for preventing COVID-19;
* On the same blood samples, look for molecules related to the heart and blood for preventing COVID-19;
* Determine if psychosocial factors are important to prevent COVID-19;
* Bank the blood samples and associated data (in the DISCoVER biobank) for the purpose of contributing to health research studies on COVID-19 and related diseases.
- Start Year
- 2020
- End Year
- 2022
| Investigators | Contacts |
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Design
- Study design
- Cohort
- Follow Up
- After it's determined whether participants are COVID positive or negative at day 0, they are followed-up at day 7, at months 1, 3 and 6.
Recruitment
- Recruitment Target
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- Individuals
Number of Participants
- Number of Participants
- 850
- Number of Participants with Biological Samples
- 850
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Timeline
DISCoVER population
The population is composed of individuals who are 65 years and older, residing in long-term care facilities and who have been tested for COVID-19.
Selection Criteria
- Minimum age
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65
- Newborns
- Twins
- Countries
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- Canada
- Territory
- Ethnic Origin
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- Health Status
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- Other Criteria
- Exclusion: Cannot fill out the form in english nor french, or has been transferred in other hospital than the McGill University Health Centre, has not given consentment
Recruitment
- Sources of recruitment
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- Specific population
- Specific Population
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- Clinic patients
- Supplementary Information
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Participants were recruited from long-term facilities such as "Centre d'hébergement et de soins de longue durée (CHSLDs)", Intermediate Resources (IR), or seniors' residence. The care staff will carry out the required pre-consent process to their residents being identified as COVID positive, and also to those identified as COVID negative.
Number of Participants
- Number of Participants
- 850
- Number of Participants with Biological Samples
- 850
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
DISCoVER - Day 0
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Psychosocial interviews were conducted to collect in-depth perspective and lived experience (i.e. challenges and needs) during the COVID-19 pandemic. Quantitative psychosocial evaluations were ... | 2020-11 | |
| 1 |
DISCoVER - Day 7
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At day 7, blood samples were collected for plasma, DNA, RNA and cells studies analysis in the future. Clinical data (sociodemographic factors, symptoms related to COVID, medication) were ... | 2020-11 | |
| 2 |
DISCoVER - Month 1
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Psychosocial interviews were conducted to collect in-depth perspective and lived experience (i.e. challenges and needs) during the COVID-19 pandemic. Quantitative psychosocial evaluations were ... | 2020-12 | |
| 3 |
DISCoVER - Month 3
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Psychosocial interviews were conducted to collect in-depth perspective and lived experience (i.e. challenges and needs) during the COVID-19 pandemic. Quantitative psychosocial evaluations were ... | 2021-02 | |
| 4 |
DISCoVER - Month 6
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Psychosocial interviews were conducted to collect in-depth perspective and lived experience (i.e. challenges and needs) during the COVID-19 pandemic. Quantitative psychosocial evaluations were ... | 2021-05 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
- Cognitive functioning
- Personality
- Psychological distress and emotions
- Other psychological measures and assessments
- Perception of health
- Quality of life
- Life course development
- Functional limitations
- Other perception of health, quality of life and functional limitation-related information
- Tobacco
- Alcohol
- Drugs
- Nutrition
- Breastfeeding
- Physical activity
- Sleep
- Sexual behaviours and orientation
- Technological devices
- Misbehaviour and criminality
- Other and unspecified lifestyle information
Socio-demographic and economic characteristics
Age/birthdate
Sex/gender
Marital/partner status
Family and household structure
Education
Residence
Birthplace
Ethnicity, race and religion
Lifestyle and behaviours
Tobacco
Drugs
Sleep
Perception of health, quality of life, development and functional limitations
Perception of health
Quality of life
Functional limitations
Diseases
Certain infectious and parasitic diseases (A00-B99)
Neoplasms (C00-D48)
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
Endocrine, nutritional and metabolic diseases (E00-E90)
Mental and behavioural disorders (F00-F99)
Diseases of the nervous system (G00-G99)
Diseases of the eye and adnexa (H00-H59)
Diseases of the ear and mastoid process (H60-H95)
Diseases of the circulatory system (I00-I99)
Diseases of the respiratory system (J00-J99)
Diseases of the digestive system (K00-K93)
Diseases of the musculoskeletal system and connective tissue (M00-M99)
Diseases of the genitourinary system (N00-N99)
Injury, poisoning and certain other consequences of external causes (S00-T98)
Diseases without precise specification or falling into multiple categories
Symptoms and signs
Symptoms and signs involving the circulatory and respiratory systems (R00-R09)
Symptoms and signs involving the digestive system and abdomen (R10-R19)
Symptoms and signs involving the skin and subcutaneous tissue (R20-R23)
Symptoms and signs involving cognition, perception, emotional state and behaviour (R40-R46)
Symptoms and signs involving speech and voice (R47-R49)
General symptoms and signs (R50-R69)
Symptoms related to multiple categories
Medication and supplements
Medication and supplement intake
Non-pharmacological interventions
Laboratory diagnosis interventions
Other and unspecified non-pharmacological interventions
Health and community care services utilization
Hospitalizations
Community and social care
Other health and community care
Death
Vital status
Other end of life or death-related information
Physical measures and assessments
Anthropometry
Circulation and respiration
Brain and nerves
Other physical measures and assessments
Laboratory measures
Hematology
Biochemistry
Virology
Immunology
Cognition, personality and psychological measures and assessments
Cognitive functioning
Psychological distress and emotions
Other psychological measures and assessments
Social environment and relationships
Social network
Social participation
Social support
Administrative information
Identifiers
Date and time-related information
Questionnaire and interview-related information
Physical and cognitive measure and biosample-related information
Data and sample collection center-related information
Other administrative information
Cognitive functioning
Informant Questionnaire on Cognitive Decline in the Elderly
Memory and Aging Telephone Screen
Montreal Cognitive Assessment
Psychological distress and emotions
Geriatric Anxiety Inventory
Geriatric Depression Scale
Neuropsychiatric Inventory
Quality of life
Alzheimer’s Disease-Related Quality of Life - Social Interaction
Brief Pain Inventory
Functional Assessment of Chronic Illness Therapy-Fatigue Scale
Functional limitations
Clinical Frailty Scale
Strength, Assistance with walking, Rising from a chair, Climbing stairs, and Falls Questionnaire
Sleep
Pittsburgh Sleep Quality Index