The 10/66 Dementia Research Group Population-Based Cohort Study
10/66 aims to provide a detailed evidence-base to inform the development and implementation of policies for improving the health and social welfare of older people in low and middle income countries, particularly the 14 million people with dementia, their relatives and carers.
The 10/66 population-based study aims to:
• Create a publicly accessible data archive;
• Use these data for comparative descriptive analyses of dementia prevalence, and its associated impact;
• Model dementia prevalence, examining the effects of age, education, literacy, socioeconomic status, urban vs rural setting, historical levels of infant mortality, economic development and industrialization;
• Estimate the annual incidence rate of dementia and its subtypes, by age group, education and centre, and to investigate risk factors for incident dementia and Alzheimer’s disease;
• Confirm the predictive validity of the survey dementia diagnoses and Mild Cognitive Impairment (MCI) through follow-up of all dementia and MCI cases.
- Start Year
- 2003
Visit 10/66
| Investigators | Contacts |
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Design
- Study design
- Cohort
- Follow Up
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The first wave of surveys started in 2003. A first follow-up was carried out between 2007 and 2010 and a third wave of assessment using an extended form of the basic 10/66 survey will start in 2016.
All the countries with the exception of urban India had a full follow-up. In India, a follow-up was only carried out for the mortality outcome.
- Supplementary Information
- Prince, M., Ferri, C. P., Acosta, D., Albanese, E., Arizaga, R., Dewey, M., . . . Uwakwe, R. (2007). The protocols for the 10/66 dementia research group population-based research programme. BMC Public Health, 7, 165. PUBMED 17659078
Marker Paper
A. Matthew Prina*, Daisy Acosta, Isaac Acostas, Mariella Guerra, YueqinHuang, AT Jotheeswaran, Ivonne Z. Jimenez-Velazquez, ZhaoruiLiu, Juan J LlibreRodriguez, Aquiles Salas, Ana Luisa Sosa, Joseph D Williams, Martin Prince. (2016) CohortProfile: the 10/66 study. International Journal of Epidemiology. In press
PUBMED 27154633
Recruitment
- Recruitment Target
-
- Individuals
Number of Participants
- Number of Participants
- 15,901
- Number of Participants with Biological Samples
- 9,178
- Supplementary Information
- By site, the numbers and proportions providing samples were: Cuba (2 355, 80.4% of those participating in the survey), Dominican Republic (1 483, 73.8%), Puerto Rico (1 584, 78.8%), Venezuela (1 284, 65.3%), urban Peru (755, 54.7%), urban Mexico (822, 82.0%), and rural Mexico (895, 89.5%)
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Timeline
Populations
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- Cuba
- Territory
- One catchment area comprising sites in Havana and Matanzas
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- General Population
-
- Selected sample
- Supplementary Information
-
Mapping of the catchment areas was carried out within specified boundaries, and households were allocated household identification numbers. Enumeration was carried out by door-knocking all households in the catchment area to identify potentially eligible participants (those aged 65 years or over on a census date) who were allocated participant identification numbers.
Number of Participants
- Number of Participants
- 2,813
- Number of Participants with Biological Samples
- 2,355
- Supplementary Information about selection criteria
- Baseline: 2813 participants
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
10/66 - Cuba - Baseline
|
Interview were generally carried out in participants’ own homes. The information collected during the interview included measures of cognitive function, mental disorders, physical ... |
2003-11 | 2005-07 |
| 1 |
10/66 - Cuba - Follow-up 1
|
The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia. The information collected during the interview included ... |
2008-04 | 2010-05 |
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- India
- Territory
- Chennai
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- General Population
-
- Selected sample
- Supplementary Information
-
Mapping of the catchment areas was carried out within specified boundaries, and households were allocated household identification numbers. Enumeration was carried out by door-knocking all households in the catchment area to identify potentially eligible participants (those aged 65 years or over on a census date) who were allocated participant identification numbers.
Number of Participants
- Number of Participants
- 2,004
- Number of Participants with Biological Samples
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
10/66 - India - Baseline
|
Interview were generally carried out in participants’ own homes. The information collected during the interview included measures of cognitive function, mental disorders, physical ... |
2004-03 | 2006-02 |
| 1 |
10/66 - India - Follow-up 1
|
Follow up was only carried out for the mortality outcome. For those who died between baseline and follow-up, a verbal autopsy interview with a co-resident, relative or other person ... |
2008-07 | 2008-09 |
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- China
- Territory
- Xicheng, Beijing province
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- General Population
-
- Selected sample
- Supplementary Information
-
Mapping of the catchment areas was carried out within specified boundaries, and households were allocated household identification numbers. Enumeration was carried out by door-knocking all households in the catchment area to identify potentially eligible participants (those aged 65 years or over on a census date) who were allocated participant identification numbers.
Number of Participants
- Number of Participants
- 1,160
- Number of Participants with Biological Samples
- Supplementary Information about selection criteria
-
Baseline: 1160 participants
Follow-up 1: 1160 participants
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
10/66 - Urban China - Baseline
|
Interview were generally carried out in participants’ own homes. The information collected during the interview included measures of cognitive function, mental disorders, physical ... |
2004-04 | 2004-12 |
| 1 |
10/66 - Urban China - Follow-up 1
|
The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia. The information collected during the interview included ... |
2009-05 | 2009-12 |
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- China
- Territory
- Daxing, Beijing province
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- General Population
-
- Selected sample
- Supplementary Information
-
Mapping of the catchment areas was carried out within specified boundaries, and households were allocated household identification numbers. Enumeration was carried out by door-knocking all households in the catchment area to identify potentially eligible participants (those aged 65 years or over on a census date) who were allocated participant identification numbers.
Number of Participants
- Number of Participants
- 1,002
- Number of Participants with Biological Samples
- Supplementary Information about selection criteria
-
Baseline: 1002 participants
Follow-up 1: 1002 participants
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
10/66 - Rural China - Baseline
|
Interview were generally carried out in participants’ own homes. The information collected during the interview included measures of cognitive function, mental disorders, physical ... |
2004-04 | 2005-02 |
| 1 |
10/66 - Rural China - Follow-up 1
|
The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia. The information collected during the interview included ... |
2009-07 | 2009-11 |
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- Dominican Republic
- Territory
- Santo Domingo
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- General Population
-
- Selected sample
- Supplementary Information
-
Mapping of the catchment areas was carried out within specified boundaries, and households were allocated household identification numbers. Enumeration was carried out by door-knocking all households in the catchment area to identify potentially eligible participants (those aged 65 years or over on a census date) who were allocated participant identification numbers.
Number of Participants
- Number of Participants
- 2,011
- Number of Participants with Biological Samples
- 1,483
- Supplementary Information about selection criteria
-
Baseline: 2011 participants
Follow-up 1: 1706 participants
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
10/66 - Dominican Republic - Baseline
|
Interview were generally carried out in participants’ own homes. The information collected during the interview included measures of cognitive function, mental disorders, physical ... |
2004-09 | 2005-09 |
| 1 |
10/66 - Dominican Republic - Follow-up 1
|
The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia. The information collected during the interview included ... |
2009-06 | 2010-11 |
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- Venezuela
- Territory
- Caracas
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- General Population
-
- Selected sample
- Supplementary Information
-
Mapping of the catchment areas was carried out within specified boundaries, and households were allocated household identification numbers. Enumeration was carried out by door-knocking all households in the catchment area to identify potentially eligible participants (those aged 65 years or over on a census date) who were allocated participant identification numbers.
Number of Participants
- Number of Participants
- 1,965
- Number of Participants with Biological Samples
- 1,284
- Supplementary Information about selection criteria
-
Baseline: 1965 participants
Follow-up 1: 507 participants
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
10/66 - Venezuela - Baseline
|
Interview were generally carried out in participants’ own homes. The information collected during the interview included measures of cognitive function, mental disorders, physical ... |
2005-02 | 2006-07 |
| 1 |
10/66 - Venezuela - Follow-up 1
|
The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia. The information collected during the interview included ... |
2009-08 | 2010-08 |
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- Peru
- Territory
- Lima
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- General Population
-
- Selected sample
- Supplementary Information
-
Mapping of the catchment areas was carried out within specified boundaries, and households were allocated household identification numbers. Enumeration was carried out by door-knocking all households in the catchment area to identify potentially eligible participants (those aged 65 years or over on a census date) who were allocated participant identification numbers.
Number of Participants
- Number of Participants
- 1,381
- Number of Participants with Biological Samples
- 755
- Supplementary Information about selection criteria
-
Baseline: 1381 participants
Follow-up 1: 1697 participants
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
10/66 - Urban Peru - Baseline
|
Interview were generally carried out in participants’ own homes. The information collected during the interview included measures of cognitive function, mental disorders, physical ... |
2005-03 | 2006-08 |
| 1 |
10/66 - Urban Peru - Follow-up 1
|
The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia. The information collected during the interview included ... |
2009-09 | 2010-07 |
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- Peru
- Territory
- Canete Province
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- General Population
-
- Selected sample
- Supplementary Information
-
Mapping of the catchment areas was carried out within specified boundaries, and households were allocated household identification numbers. Enumeration was carried out by door-knocking all households in the catchment area to identify potentially eligible participants (those aged 65 years or over on a census date) who were allocated participant identification numbers.
Number of Participants
- Number of Participants
- 552
- Number of Participants with Biological Samples
- Supplementary Information about selection criteria
-
Baseline: 552 participants
Follow-up 1: 552 participants
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
10/66 - Rural Peru - Baseline
|
Interview were generally carried out in participants’ own homes. The information collected during the interview included measures of cognitive function, mental disorders, physical ... |
2005-12 | 2006-04 |
| 1 |
10/66 - Rural Peru - Follow-up 1
|
The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia. The information collected during the interview included ... |
2009-09 | 2009-12 |
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- Mexico
- Territory
- Mexico city
- Ethnic Origin
-
- Health Status
-
Recruitment
- Supplementary Information
-
Mapping of the catchment areas was carried out within specified boundaries, and households were allocated household identification numbers. Enumeration was carried out by door-knocking all households in the catchment area to identify potentially eligible participants (those aged 65 years or over on a census date) who were allocated participant identification numbers.
Number of Participants
- Number of Participants
- 1,003
- Number of Participants with Biological Samples
- 822
- Supplementary Information about selection criteria
-
Baseline: 1003 participants
Follow-up 1: 911 participants
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
10/66 - Urban Mexico - Baseline
|
Interview were generally carried out in participants’ own homes. The information collected during the interview included measures of cognitive function, mental disorders, physical ... |
2005-12 | 2007-03 |
| 1 |
10/66 - Urban Mexico - Follow-up 1
|
The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia. The information collected during the interview included ... |
2009-01 | 2010-05 |
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- Mexico
- Territory
- Morelos State
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- General Population
-
- Selected sample
- Supplementary Information
-
Mapping of the catchment areas was carried out within specified boundaries, and households were allocated household identification numbers. Enumeration was carried out by door-knocking all households in the catchment area to identify potentially eligible participants (those aged 65 years or over on a census date) who were allocated participant identification numbers.
Number of Participants
- Number of Participants
- 1,000
- Number of Participants with Biological Samples
- 895
- Supplementary Information about selection criteria
-
Baseline: 1000 participants
Follow-up 1: 933 participants
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
10/66 - Rural Mexico - Baseline
|
Interview were generally carried out in participants’ own homes. The information collected during the interview included measures of cognitive function, mental disorders, physical ... |
2006-08 | 2007-02 |
| 1 |
10/66 - Rural Mexico - Follow-up 1
|
The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia. The information collected during the interview included ... |
2009-08 | 2010-04 |
Selection Criteria
- Minimum age
-
65
- Newborns
- Twins
- Countries
-
- Puerto Rico
- Territory
- Bayamon
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- General Population
-
- Selected sample
- Supplementary Information
-
Mapping of the catchment areas was carried out within specified boundaries, and households were allocated household identification numbers. Enumeration was carried out by door-knocking all households in the catchment area to identify potentially eligible participants (those aged 65 years or over on a census date) who were allocated participant identification numbers.
Number of Participants
- Number of Participants
- 2,009
- Number of Participants with Biological Samples
- 1,584
- Supplementary Information about selection criteria
-
Baseline: 2009 participants
Follow-up 1: 1567 participants
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
10/66 - Puerto Rico - Baseline
|
Interview were generally carried out in participants’ own homes. The information collected during the interview included measures of cognitive function, mental disorders, physical ... |
2007-08 | 2009-01 |
| 1 |
10/66 - Puerto Rico - Follow-up 1
|
The interviews for the incidence phase largely involved a repeat of the baseline, with the aim of identifying incident dementia. The information collected during the interview included ... |
2012-05 | 2013-10 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
- Cognitive functioning
- Personality
- Psychological distress and emotions
- Other psychological measures and assessments
- Perception of health
- Quality of life
- Life course development
- Functional limitations
- Other perception of health, quality of life and functional limitation-related information
Socio-demographic and economic characteristics
Lifestyle and behaviours
Birth, pregnancy and reproductive health history
Perception of health, quality of life, development and functional limitations
Diseases
Symptoms and signs
Medication and supplements
Non-pharmacological interventions
Health and community care services utilization
Death
Physical measures and assessments
Cognition, personality and psychological measures and assessments
Life events, life plans, beliefs and values
Preschool, school and work life
Social environment and relationships
Physical environment
Administrative information
Cognitive functioning
Psychological distress and emotions
Functional limitations