The Canadian Lung Outcomes in Users of Vaping Devices Study
Networks
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Datasets
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Variables
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The Canadian Lung Outcomes in Users of Vaping Devices (CLOUD) study purpose is to advance knowledge of the effects of vaping on the lung health and overall well-being of adults and adolescents across Canada.
The specific aims are:
Aim 1. Determine the lung health impact of Electronic Nicotine Delivery Systems (ENDS) use in Canadian adolescents:
* To characterize the structural and functional disruptions associated with ENDS use, through oscillometry, multiple breath washout, MR imaging, and cardiopulmonary exercise testing will be used.
* Quantify the association between ENDS use and poor respiratory outcomes, including symptoms, respiratory-related events, and school absences.
* Characterize epigenetic and transcriptomic disruptions associated with ENDS use in induced sputum.*
Aim 2. Determine the lung health impact of ENDS use in Canadian adults:
* To characterize structural and functional disruptions associated with ENDS use through oscillometry, CT and MR imaging, and cardiopulmonary exercise testing.
* To quantify the association between ENDS use and poor respiratory outcomes, including symptoms, respiratory-related events, and work absences.
* To characterize epigenetic and transcriptomic disruptions associated with ENDS use in the small airway epithelium and immune cells.
- Start Year
- 2025
Visit CLOUD
| Investigators | Contacts |
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Design
- Study design
- Cohort
- Follow Up
- After baseline, participants are followed every 3 months and at 18 and 36 months.
Marker Paper
Burns P, Eddy RL, Li X, et al. The Canadian Lung Outcomes in Users of Vaping Devices (CLOUD) Study: protocol for a prospective, observational cohort study. BMJ Open, 2025; 15(3): e100568. https://doi.org/10.1136/bmjopen-2025-100568.
PUBMED 40050062
Recruitment
- Recruitment Target
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- Individuals
Number of Participants
- Number of Participants
- 500
- Number of Participants with Biological Samples
- 500
- Supplementary Information
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Planned reccuited participants: 500 participants.
Adults : 400 participants
Adolescents: 100 participants
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Availability of access information
By contacting the study representative
Sector of research
| Possible Access to Data | Possible Access to Biosamples | |
|---|---|---|
| Investigators from the public sector | ||
| Investigators from the private sector | ||
| Investigators from not-for-profit organization |
Transfer
| Possible Access to Data | Possible Access to Biosamples | |
|---|---|---|
| Can leave the study facility | ||
| Can leave the country |
All data and biospecimens leaving the study will be de-identified.
Cost
| Possible Access to Data | Variable Cost |
| Possible Access to Biosamples | Variable Cost |
Cost reduction for co-analyses
| Possible Access to Data | |
| Possible Access to Biosamples |
Timeline
Populations
The population is composed of adults who are able to participate in Vancouver (British Columbia), Edmonton (Alberta), Hamilton (Ontario), Ottawa (Ontario), or Sherbrooke (Quebec).
Selection Criteria
- Minimum age
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19
- Newborns
- Twins
- Countries
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- Canada
- Territory
- Vancouver, Edmonton, Hamilton, Ottawa, Sherbrooke
- Ethnic Origin
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- Health Status
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- Other Criteria
- Non-smoking and non-ENDS using participants will be recruited to match the age and sex distribution of the ENDS and cigarette smoking groups.
Recruitment
- Sources of recruitment
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- General population
- General Population
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- Volunteer enrolment
- Supplementary Information
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Participants are recruited through social media, educational initiatives in schools, awareness programs, the study website, and online health research platforms like REACH BC.
Number of Participants
- Number of Participants
- 400
- Number of Participants with Biological Samples
- 400
- Supplementary Information about selection criteria
- **This population includes:** * 100 ENDS-only users * 100 combustible cigarette-only users * 100 dual e-cigarette and combustible cigarette users * 100 non-smoking and non-e-cigarette users
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
CLOUD - Adults - Visit 1
|
Demographic, exposure, and medical history, along with vaping habits (device type, frequency, e-liquid composition, and flavorings), are recorded. Vaping dependence is assessed using the modified ... | 2025-05 | 2027-05 |
| 1 |
CLOUD - Adults - Online survey 1
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2025-08 | 2025-08 |
| 2 |
CLOUD - Adults - Online survey 2
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2025-11 | 2025-11 |
| 3 |
CLOUD - Adults - Online survey 3
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2026-02 | 2026-02 |
| 4 |
CLOUD - Adults - Online survey 4
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2026-05 | 2026-05 |
| 5 |
CLOUD - Adults - Online survey 5
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2026-08 | 2026-08 |
| 6 |
CLOUD - Adults - Visit 2
|
Demographic, exposure, and medical history, along with vaping habits (device type, frequency, e-liquid composition, and flavorings), are recorded. Vaping dependence is assessed using the modified ... | 2026-11 | 2028-11 |
| 7 |
CLOUD - Adults - Online survey 6
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2026-11 | 2026-11 |
| 8 |
CLOUD - Adults - Online survey 7
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2027-02 | 2027-02 |
| 9 |
CLOUD - Adults - Online survey 8
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2027-05 | 2027-05 |
| 10 |
CLOUD - Adults - Online survey 9
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2027-08 | 2027-08 |
| 11 |
CLOUD - Adults - Online survey 10
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2027-11 | 2027-11 |
| 12 |
CLOUD - Adults - Online survey 11
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2028-02 | 2028-02 |
| 13 |
CLOUD - Adults - Visit 3
|
Demographic, exposure, and medical history, along with vaping habits (device type, frequency, e-liquid composition, and flavorings), are recorded. Vaping dependence is assessed using the modified ... | 2028-05 | 2029-12 |
| 14 |
CLOUD - Adults - Online survey 12
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2028-05 | 2028-05 |
| 15 |
CLOUD - Adults - Online survey 13
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2028-08 | 2028-08 |
| 16 |
CLOUD - Adults - Online survey 14
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2028-11 | 2028-11 |
| 17 |
CLOUD - Adults - Online survey 15
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2029-02 | 2029-02 |
| 18 |
CLOUD - Adults - Online survey 16
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2029-05 | 2029-05 |
| 19 |
CLOUD - Adults - Online survey 17
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2029-08 | 2029-08 |
| 20 |
CLOUD - Adults - Online survey 18
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2029-11 | 2029-11 |
The population is composed of adolescents who are able to participate in Vancouver (British Columbia), Edmonton (Alberta), Toronto (Ontario), or Sherbrooke (Quebec).
Selection Criteria
- Minimum age
-
12
- Maximum age
-
18
- Newborns
- Twins
- Countries
-
- Canada
- Territory
- Vancouver, Edmonton, Toronto, Sherbrooke
- Ethnic Origin
-
- Health Status
-
- Other Criteria
- Non-smoking and non-ENDS using participants will be recruited to match the age and sex distribution of the ENDS and cigarette smoking groups.
Recruitment
- Sources of recruitment
-
- General population
- General Population
-
- Volunteer enrolment
- Supplementary Information
-
Participants are recruited through social media, educational initiatives in schools, awareness programs, the study website, and online health research platforms like REACH BC.
Number of Participants
- Number of Participants
- 100
- Number of Participants with Biological Samples
- 100
- Supplementary Information about selection criteria
- **This population includes** * 50 ENDS users * 50 non-e-cigarette users
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
CLOUD - Adolescents - Visit 1
|
Demographic, exposure, and medical history, along with vaping habits (device type, frequency, e-liquid composition, and flavorings), are recorded. Vaping dependence is assessed using the modified ... | 2025-05 | 2027-05 |
| 1 |
CLOUD - Adolescents - Online Survey 1
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2025-08 | 2025-08 |
| 2 |
CLOUD - Adolescents - Online Survey 2
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2025-11 | 2025-11 |
| 3 |
CLOUD - Adolescents - Online Survey 3
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2026-02 | 2026-02 |
| 4 |
CLOUD - Adolescents - Online Survey 4
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2026-05 | 2026-05 |
| 5 |
CLOUD - Adolescents - Online Survey 5
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2026-08 | 2026-08 |
| 6 |
CLOUD - Adolescents - Visit 2
|
Information on the use of electronic nicotine delivery systems (ENDS), e-cigarettes, and traditional cigarettes, changes in product usage, and any respiratory symptoms is collected. Pulmonary ... |
2026-11 | 2028-11 |
| 7 |
CLOUD - Adolescents - Online Survey 6
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2026-11 | 2026-11 |
| 8 |
CLOUD - Adolescents - Online Survey 7
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2027-02 | 2027-02 |
| 9 |
CLOUD - Adolescents - Online Survey 8
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2027-05 | 2027-05 |
| 10 |
CLOUD - Adolescents - Online Survey 9
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2027-08 | 2027-08 |
| 11 |
CLOUD - Adolescents - Online Survey 10
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2027-11 | 2027-11 |
| 12 |
CLOUD - Adolescents - Online Survey 11
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2028-02 | 2028-02 |
| 13 |
CLOUD - Adolescents - Visit 3
|
Demographic, exposure, and medical history, along with vaping habits (device type, frequency, e-liquid composition, and flavorings), are recorded. Vaping dependence is assessed using the modified ... | 2028-05 | 2029-12 |
| 14 |
CLOUD - Adolescents - Online Survey 12
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2028-05 | 2028-05 |
| 15 |
CLOUD - Adolescents - Online Survey 13
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2028-08 | 2028-08 |
| 16 |
CLOUD - Adolescents - Online Survey 14
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2028-11 | 2028-11 |
| 17 |
CLOUD - Adolescents - Online Survey 15
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2029-02 | 2029-02 |
| 18 |
CLOUD - Adolescents - Online Survey 16
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2029-05 | 2029-05 |
| 19 |
CLOUD - Adolescents - Online Survey 17
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2029-08 | 2029-08 |
| 20 |
CLOUD - Adolescents - Online Survey 18
|
Exacerbation-like respiratory events, defined as changes in at least one major respiratory symptom and the use of antibiotics and/or systemic corticosteroids or health services (physician visit, ... | 2029-11 | 2029-11 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
Socio-demographic and economic characteristics
Lifestyle and behaviours
Diseases
Symptoms and signs
Medication and supplements
Non-pharmacological interventions
Health and community care services utilization
Physical measures and assessments
Laboratory measures
Preschool, school and work life
Physical environment