Cellular Immunity and Seroprevalence of Antibodies against SARS-CoV-2: Characterisation of Three Populations of Food Workers
Networks
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Datasets
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Variables
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The main objective of this project is to determine the immune response against SARS-CoV-2 in 3 worker populations using a group of hardware workers as a comparator.
Specifically, this study will serve to:
* Determine the seroprevalence of antibodies to SARS-CoV-2 by different techniques;
* Measure the incidence of SARS-CoV-2 infection at 12 and 24 weeks;
* Compare the different serological techniques used in this study;
* Measure the innate response at time 0 and 24 weeks;
* Measure the acquired cellular response at time 0 and 24 weeks;
* Define the demographic characteristics of these populations;
* Describe the protective measures used at work;
* Determine the risk factors associated with severe COVID case in this population;
* Establish correlations between risk factors and SARS-CoV-2 infection;
* Establish correlations between the different arms of the immune system;
* Validate two new serological tests; and
* Explore the immune response to the vaccine in vaccinated participants.
- Start Year
- 2021
- End Year
- 2022
| Investigators | Contacts |
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Design
- Study design
- Cohort
- Follow Up
- After enrollment (time 0), participants are followed-up at 12 and 24 weeks. A supplementary visit took place for participants who tested positive for SARS-CoV-2 by PCR.
Recruitment
- Recruitment Target
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- Individuals
Number of Participants
- Number of Participants
- 600
- Number of Participants with Biological Samples
- 600
- Supplementary Information
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Grocery store workers: 150 participants
Food workers: 300 participants
Hardware store workers: 150 participants
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Timeline
Populations
The population is composed of 18 years old and older individuals who work at a grocery store in the regions of Capitale Nationale or Chaudière-Appalaches in Quebec, Canada, who have been present at work at least for 20 days since February 1st, 2020 and were in contact with the public in the course of work.
Selection Criteria
- Minimum age
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18
- Newborns
- Twins
- Countries
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- Canada
- Territory
- Capitale Nationale, Chaudière-Appalaches, Quebec
- Ethnic Origin
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- Health Status
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- Absence of active COVID; no anemia.
- Other Criteria
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Inclusion: Occupation as a retailer, in contact with the public in the course of work and present at work for at least 20 days starting from February 1st, 2020, and able to come to CHUL for the study.
Exclusion: Was in contact with a COVID-19 case in the last 14 days, was hospitalized for COVID-19, has donated blood in the last 4 weeks, or is pregnant.
Recruitment
- Sources of recruitment
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- Specific population
- Specific Population
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- Other specific population : Workers in a grocery store.
- Supplementary Information
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Participants were recruited by sending workers a letter or an email explaining the study via the distribution lists of the Confederation of National Trade Unions (CSN) and the Quebec Hardware and Building Supply Association (AQMAT) and inviting them to contact the study team if interested.
Number of Participants
- Number of Participants
- 150
- Number of Participants with Biological Samples
- 150
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
CISACOV - Grocery store workers - Enrollment
|
Information about sociodemographic, COVID-19 related tests, symptoms, risk factors and health measures, and work (location, position, type of protection at work) was collected. Height and ... | 2021-04 | 2021-09 |
| 1 |
CISACOV - Grocery store workers - Week 12
|
Information about COVID-19 symptoms and vaccination was collected. A blood sample was collected to study humoral immunity (serology) against SARS-CoV-2. | 2021-06 | 2021-12 |
| 2 |
CISACOV - Grocery store workers - Week 24
|
Information about COVID-19 symptoms and vaccination was collected. A blood sample was collected to study humoral immunity (serology), innate and cellular immunity against SARS-CoV-2. | 2021-09 | 2022-03 |
| 3 |
CISACOV - Grocery store workers - COVID positive
|
After a quarantine period, information about date of positive PCR, COVID symptoms, history of contact with a COVID case and evolution of the disease (hospitalized or not) was collected. A blood ... | 2021-03 | 2022-03 |
The population is composed of 18 years old and older individuals who work at a restaurant or bar in the regions of Capitale Nationale or Chaudière-Appalaches in Quebec, Canada, who have been present at work at least for 20 days since February 1st, 2020 and were in contact with the public in the course of work.
Selection Criteria
- Minimum age
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18
- Newborns
- Twins
- Countries
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- Canada
- Territory
- Capitale Nationale, Chaudière-Appalaches, Quebec
- Ethnic Origin
-
- Health Status
-
- Absence of active COVID; no anemia.
- Other Criteria
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Inclusion: Occupation as a retailer, in contact with the public in the course of work and present at work for at least 20 days starting from February 1st, 2020, and able to come to CHUL for the study.
Exclusion: Was in contact with a COVID-19 case in the last 14 days, was hospitalized for COVID-19, has donated blood in the last 4 weeks, or is pregnant.
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
-
- Other specific population : Workers in a restaurant or bar.
- Supplementary Information
-
Participants were recruited by sending workers a letter or an email explaining the study via the distribution lists of the Confederation of National Trade Unions (CSN) and the Quebec Hardware and Building Supply Association (AQMAT) and inviting them to contact the study team if interested.
Number of Participants
- Number of Participants
- 300
- Number of Participants with Biological Samples
- 300
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
CISACOV - Food workers - Enrollment
|
Information about sociodemographic, COVID-19 related tests, symptoms, risk factors and health measures, and work (location, position, type of protection at work) was collected. Height and ... | 2021-04 | 2021-09 |
| 1 |
CISACOV - Food workers - Week 12
|
Information about COVID-19 symptoms and vaccination was collected. A blood sample was collected to study humoral immunity (serology) against SARS-CoV-2. | 2021-06 | 2021-12 |
| 2 |
CISACOV - Food workers - Week 24
|
Information about COVID-19 symptoms and vaccination was collected. A blood sample was collected to study humoral immunity (serology), innate and cellular immunity against SARS-CoV-2. | 2021-09 | 2022-03 |
| 3 |
CISACOV - Food workers - COVID positive
|
After a quarantine period, information about date of positive PCR, COVID symptoms, history of contact with a COVID case and evolution of the disease (hospitalized or not) was collected. A blood ... | 2021-03 | 2022-03 |
The population is composed of 18 years old and older individuals who work at a hardware store in the regions of Capitale Nationale or Chaudière-Appalaches in Quebec, Canada, who have been present at work at least for 20 days since February 1st, 2020 and were in contact with the public in the course of work.
Selection Criteria
- Minimum age
-
18
- Newborns
- Twins
- Countries
-
- Canada
- Territory
- Capitale Nationale, Chaudière-Appalaches, Quebec
- Ethnic Origin
-
- Health Status
-
- Absence of active COVID; no anemia.
- Other Criteria
-
Inclusion: Occupation as a retailer, in contact with the public in the course of work and present at work for at least 20 days starting from February 1st, 2020, and able to come to CHUL for the study.
Exclusion: Was in contact with a COVID-19 case in the last 14 days, was hospitalized for COVID-19, has donated blood in the last 4 weeks, or is pregnant.
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
-
- Other specific population : Workers in a hardware store.
- Supplementary Information
-
Participants were recruited by sending workers a letter or an email explaining the study via the distribution lists of the Confederation of National Trade Unions (CSN) and the Quebec Hardware and Building Supply Association (AQMAT) and inviting them to contact the study team if interested.
Number of Participants
- Number of Participants
- 150
- Number of Participants with Biological Samples
- 150
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
CISACOV - Hardware store workers - Enrollment
|
Information about sociodemographic, COVID-19 related tests, symptoms, risk factors and health measures, and work (location, position, type of protection at work) was collected. Height and ... | 2021-04 | 2021-09 |
| 1 |
CISACOV - Hardware store workers - Week 12
|
Information about COVID-19 symptoms and vaccination was collected. A blood sample was collected to study humoral immunity (serology) against SARS-CoV-2. | 2021-06 | 2021-12 |
| 2 |
CISACOV - Hardware store workers - Week 24
|
Information about COVID-19 symptoms and vaccination was collected. A blood sample was collected to study humoral immunity (serology) against SARS-CoV-2. | 2021-09 | 2022-03 |
| 3 |
CISACOV - Hardware store workers - COVID positive
|
After a quarantine period, information about date of positive PCR, COVID symptoms, history of contact with a COVID case and evolution of the disease (hospitalized or not) was collected. A blood ... | 2021-03 | 2022-03 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
Socio-demographic and economic characteristics
Age/birthdate
Sex/gender
Family and household structure
Education
Residence
Ethnicity, race and religion
Labour force and retirement
Lifestyle and behaviours
Tobacco
Transportation
Personal hygiene
Leisure activities
Perception of health, quality of life, development and functional limitations
Perception of health
Diseases
Certain infectious and parasitic diseases (A00-B99)
Neoplasms (C00-D48)
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
Endocrine, nutritional and metabolic diseases (E00-E90)
Diseases of the nervous system (G00-G99)
Diseases of the circulatory system (I00-I99)
Diseases of the respiratory system (J00-J99)
Diseases of the digestive system (K00-K93)
Diseases of the genitourinary system (N00-N99)
Diseases without precise specification or falling into multiple categories
Symptoms and signs
Symptoms and signs involving the circulatory and respiratory systems (R00-R09)
Symptoms and signs involving the digestive system and abdomen (R10-R19)
Symptoms and signs involving nervous and musculoskeletal systems (R25-R29)
Symptoms and signs involving cognition, perception, emotional state and behaviour (R40-R46)
General symptoms and signs (R50-R69)
Symptoms related to multiple categories
Medication and supplements
Medication and supplement intake
Posology and protocol of administration
Non-pharmacological interventions
Laboratory diagnosis interventions
Other and unspecified non-pharmacological interventions
Health and community care services utilization
Visits to health professionals
Hospitalizations
Physical measures and assessments
Anthropometry
Laboratory measures
Virology
Immunology
Preschool, school and work life
Work life
Social environment and relationships
Social participation
Physical environment
Housing characteristics
Workplace characteristics
Administrative information
Date and time-related information
Questionnaire and interview-related information