Canadian COVID-19 Emergency Department Rapid Response Network: Real-World Vaccine Effectiveness and Duration of Protection in Special Populations
Networks
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Datasets
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Variables
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The objective of this registry is to leverage established infrastructure to create a national vaccine evaluation platform in partnership with provincial Public Health Partners.
The specific objectives are to evaluate:
1. The effectiveness of COVID-19 vaccines for preventing severe COVID-19 in priority groups, including in racialized and Indigenous communities, individuals of lower socioeconomic status (SES), those with active comorbidity (e.g., active cancer), at the extremes of ages, in pregnant and breastfeeding women, and in otherwise marginalized groups (e.g., homeless);
2. The effectiveness of COVID-19 vaccines in preventing severe disease, hospitalization and mortality, as delivered in the real-world, including single doses of vaccines authorized as two-dose series, delayed boosters, and receipt of vaccines from different manufacturers; and
3. The duration of vaccine protection from symptomatic COVID-19 in the general population and in specific groups (e.g., elderly with immune senescence), by vaccine type, for single doses of vaccines authorized as two-dose series, and in individuals receiving a delayed booster.
- Start Year
- 2021
- End Year
- 2022
Visit CCEDRRN-VE
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Design
- Study design
- Registry
- Follow Up
- Participants are followed up at 60 days, and at 6 and 12 months after visit to the emergency department.
Marker Paper
Hohl CM, Rosychuk RJ, McRae AD et al. Canadian COVID-19 Emergency Department Rapid Response Network investigators and for the Network of Canadian Emergency Researchers and the Canadian Critical Care Trials Group. Development of the Canadian COVID-19 Emergency Department Rapid Response Network population-based registry: a methodology study. CMAJ Open.E261-E270.
PUBMED 33731427
Recruitment
- Recruitment Target
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- Individuals
Number of Participants
- Number of Participants
- 80,000
- Number of Participants with Biological Samples
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Timeline
Populations
The population is composed of patients who receive care for symptomatic and severe COVID-19, and were inadequately evaluated in or excluded from phase 3 vaccine effectiveness (VE) trials in any of the 50 participating emergency departments (EDs) across 8 provinces ( Alberta, British Columbia, Manitoba, New Brunswick, Nova Scotia, Ontario, Quebec, Saskatchewan).
Selection Criteria
- Newborns
- Twins
- Countries
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- Canada
- Territory
- Ethnic Origin
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- Health Status
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- COVID-19 positive patients with active co-morbidities, with cancer including those receiving treatments for their malignancies, or with autoimmunity including those receiving treatments that may alter their immune response
- Other Criteria
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Inclusion:
Racialized communities
Indigenous communities
Individuals of lower socioeconomic status, homeless
Individuals with primary or secondary immune defects
Individuals with substance use disorder
Individuals at the extremes of ages
Recruitment
- Sources of recruitment
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- Specific population
- Specific Population
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- Other specific population : Patients who visited participating emergency departments
- Supplementary Information
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Participants were contacted for participation if they visited any of the 50 participating emergency departments and were tested for COVID -19.
Number of Participants
- Number of Participants
- 80,000
- Number of Participants with Biological Samples
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 1 |
CCEDRRN-VE - COVID-19 positive - 60 days
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Information was collected about vaccination status through a telephone call. Patient records and abstract data about demographics, history, risk factors, co-morbid conditions, medication use, ... | 2021-07 | 2021-07 |
| 2 |
CCEDRRN-VE - COVID-19 positive - 6 months
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Information was collected about vaccination status through a telephone call. Patient records and abstract data about demographics, history, risk factors, co-morbid conditions, medication use, ... | 2021-11 | 2021-11 |
| 3 |
CCEDRRN-VE - COVID-19 positive - 12 months
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Information was collected about vaccination status through a telephone call. Patient records and abstract data about demographics, history, risk factors, co-morbid conditions, medication use, ... | 2022-05 | 2022-05 |
The population is composed of patients who tested negative for COVID-19 in any of the 50 participating emergency departments (EDs) across 8 provinces ( Alberta, British Columbia, Manitoba, New Brunswick, Nova Scotia, Ontario, Quebec, Saskatchewan).
Selection Criteria
- Newborns
- Twins
- Countries
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- Canada
- Territory
- Ethnic Origin
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- Health Status
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- Tested negative for COVID-19 with active co-morbidities, with cancer including those receiving treatments for their malignancies, or with autoimmunity including those receiving treatments that may alter their immune response
- Other Criteria
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Inclusion:
Racialized communities
Indigenous communities
Individuals of lower socioeconomic status, homeless
Individuals with primary or secondary immune defects
Individuals with substance use disorder
Individuals at the extremes of ages
Recruitment
- Sources of recruitment
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- Specific population
- Specific Population
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- Other specific population : Patients who visited a participating Emergency Department
- Supplementary Information
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Participants were contacted for participation if they visited any of the 50 participating emergency departments and were tested for COVID -19.
Number of Participants
- Number of Participants
- Number of Participants with Biological Samples
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 1 |
CCEDRRN-VE - COVID-19 negative - 60 days
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Information was collected about vaccination status through a telephone call. Patient records and abstract data about demographics, history, risk factors, co-morbid conditions, medication use, ... | 2021-07 | 2021-07 |
| 2 |
CCEDRRN-VE - COVID-19 negative - 6 months
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Information was collected about vaccination status through a telephone call. Patient records and abstract data about demographics, history, risk factors, co-morbid conditions, medication use, ... | 2021-11 | 2021-11 |
| 3 |
CCEDRRN-VE - COVID-19 negative - 12 months
|
Information was collected about vaccination status through a telephone call. Patient records and abstract data about demographics, history, risk factors, co-morbid conditions, medication use, ... | 2022-05 | 2022-05 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
Socio-demographic and economic characteristics
Age/birthdate
Sex/gender
Family and household structure
Education
Residence
Citizenship and immigrant status
Ethnicity, race and religion
Labour force and retirement
Income, possessions, and benefits
Lifestyle and behaviours
Tobacco
Alcohol
Drugs
Breastfeeding
Birth, pregnancy and reproductive health history
Pregnancy, delivery and birth
Perception of health, quality of life, development and functional limitations
Quality of life
Diseases
Certain infectious and parasitic diseases (A00-B99)
Neoplasms (C00-D48)
Endocrine, nutritional and metabolic diseases (E00-E90)
Mental and behavioural disorders (F00-F99)
Diseases of the nervous system (G00-G99)
Diseases of the eye and adnexa (H00-H59)
Diseases of the ear and mastoid process (H60-H95)
Diseases of the circulatory system (I00-I99)
Diseases of the respiratory system (J00-J99)
Diseases of the digestive system (K00-K93)
Diseases of the skin and subcutaneous tissue (L00-L99)
Diseases of the musculoskeletal system and connective tissue (M00-M99)
Diseases of the genitourinary system (N00-N99)
Injury, poisoning and certain other consequences of external causes (S00-T98)
External causes of morbidity and mortality (V01-Y98)
Diseases without precise specification or falling into multiple categories
Symptoms and signs
Symptoms and signs involving the circulatory and respiratory systems (R00-R09)
Symptoms and signs involving the digestive system and abdomen (R10-R19)
Symptoms and signs involving cognition, perception, emotional state and behaviour (R40-R46)
General symptoms and signs (R50-R69)
Symptoms related to multiple categories
Medication and supplements
Medication and supplement intake
Posology and protocol of administration
Non-pharmacological interventions
Radiological interventions
Laboratory diagnosis interventions
Other and unspecified non-pharmacological interventions
Health and community care services utilization
Visits to health professionals
Hospitalizations
Death
Vital status
Other end of life or death-related information
Physical measures and assessments
Circulation and respiration
Other physical measures and assessments
Laboratory measures
Virology
Social environment and relationships
Social support
Physical environment
Biological exposure
Administrative information
Identifiers
Date and time-related information
Questionnaire and interview-related information
Physical and cognitive measure and biosample-related information
Data and sample collection center-related information
Other administrative information