Canadian COVID-19 Cohort Study: Study of the Epidemiology of COVID-19 in Canadian Healthcare Workers
Networks
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Datasets
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Variables
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The primary objectives of this study are to:
* Identify workplace (e.g., exposure to patients), community (e.g., rate of positive COVID tests), household (e.g., household crowding index), and personal (e.g., adherence to protective practices) risk factors for COVID-19 in HCWs;
* Assess whether one or more of three categories of putatively higher risk acute care hospital HCWs are indeed at higher risk of COVID-19 than other acute care hospital HCWs;
* Determine the incidence of symptomatic COVID-19 infection in HCWs;
* Estimate the incidence of asymptomatic COVID-19 infection in HCWs during the first pandemic season by measuring seroconversion to anti-SARS-CoV-2 antibodies; and
* Describe the intended and actual uptake of COVID-19 vaccines in HCWs.
Its secondary objectives are to:
* Determine the patterns of immune responses over time using dried blood spots (including post-vaccination); and
* Describe the psychological impact on HCWs during an outbreak of a novel respiratory virus.
Its exploratory objective is to:
1. Determine the incidence of reinfection,
2. Determine the effectiveness of the COVID-19 vaccine(s).
- Start Year
- 2020
- End Year
- 2022
Visit CCCS
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Design
- Study design
- Cohort
- Follow Up
- After enrollment, participants are followed-up for 12 months with weekly reports, testing/illness reports, and periodic blood samples collection. Blood samples are collected at enrolment, following vaccination against COVID, after a positive respiratory test (PCR), and every 6 months thereafter to assess antibody levels.
Recruitment
- Recruitment Target
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- Individuals
Number of Participants
- Number of Participants
- 2,460
- Number of Participants with Biological Samples
- 2,460
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Timeline
CCCS population
The population is composed of 18 to 75 years old health care workers from acute care, rehabilitation, and complex care hospitals in Canada.
Selection Criteria
- Minimum age
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18
- Maximum age
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75
- Newborns
- Twins
- Countries
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- Canada
- Territory
- Ethnic Origin
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- Health Status
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- Other Criteria
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Inclusion:
Occupation full- or part-time (>20 hours per week for health care workers, ≥ 8 hours per week for physician, nurse practitioner or midwife);
Have convenient access to and basic skills for use of computer or cell phone with internet capability;
Able to read and write English or French and available for follow-up during the study period.Exclusion: HCWs are not eligible if they plan to take leave from work for more than two consecutive weeks within the first 3 months of enrolment (e.g., vacation, maternity or medical leave, retirement).
Recruitment
- Sources of recruitment
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- Specific population
- Specific Population
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- Other specific population : Health care workers
- Supplementary Information
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- Recruitment procedures included:
- a) sending email “blasts” to hospital employees,
- b) providing short videoconference or phone presentations for team meetings/huddles,
- c) posting electronic advertisements on internal hospital communications,
- d) displaying physical posters in staff work areas,
- e) advertising on social media platforms (e.g., Twitter or Facebook), and
- f) distributing pamphlets to targeted internal mailboxes.
Number of Participants
- Number of Participants
- 2,460
- Number of Participants with Biological Samples
- 2,460
- Supplementary Information about selection criteria
Data Collection Events
| # | Name | Description | Start | End |
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| 0 |
CCCS - Baseline
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Information about personal, household, and workplace characteristics that may be associated with risk of respiratory infection was collected. A Kessler Psychological Distress Scale (K10) survey ... | 2020 | 2021 |
| 1 |
CCCS - Longitudinal Follow-up
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Information regarding symptoms of respiratory illnesses and reception of the influenza vaccine (in December) was collected from a weekly report. Additional information about symptoms of ... | 2021 | 2022 |
| 2 |
CCCS - 6-month Follow-up
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The Kessler Psychological Distress scale (K10) was administered. Blood samples were self-collected. | 2021 | 2022 |
| 3 |
CCCS - 12-month Follow-up
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The Impact of Events scale as well as the Kessler Psychological Distress scale (K10) were administered. Blood samples were self-collected. | 2022 | 2022 |
| 4 |
CCCS - Daily report
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Participants with an acute respiratory illness and/or who are tested for COVID-19 are asked to complete daily online illness reports starting when symptoms begin. The first report asked for ... | 2021 | 2022 |
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CCCS - COVID-19 Vaccination
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Information about vaccine manufacturer, vaccine lot number, and date of vaccination was collected every time participants are vaccinated. Blood samples were self-collected at day of first ... | 2021 | 2022 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
Socio-demographic and economic characteristics
Age/birthdate
Sex/gender
Family and household structure
Education
Residence
Ethnicity, race and religion
Lifestyle and behaviours
Tobacco
Leisure activities
Diseases
Certain infectious and parasitic diseases (A00-B99)
Neoplasms (C00-D48)
Endocrine, nutritional and metabolic diseases (E00-E90)
Diseases of the circulatory system (I00-I99)
Diseases of the respiratory system (J00-J99)
Diseases of the digestive system (K00-K93)
Diseases without precise specification or falling into multiple categories
Symptoms and signs
Symptoms and signs involving the circulatory and respiratory systems (R00-R09)
Symptoms and signs involving the digestive system and abdomen (R10-R19)
Symptoms and signs involving nervous and musculoskeletal systems (R25-R29)
Symptoms and signs involving cognition, perception, emotional state and behaviour (R40-R46)
General symptoms and signs (R50-R69)
Symptoms related to multiple categories
Medication and supplements
Medication and supplement intake
Non-pharmacological interventions
Laboratory diagnosis interventions
Other and unspecified non-pharmacological interventions
Laboratory measures
Virology
Physical environment
Housing characteristics
Administrative information
Identifiers
Date and time-related information
Physical and cognitive measure and biosample-related information
Other administrative information