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Canadian Multicentre Osteoporosis Study
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Canadian Multicentre Osteoporosis Study

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Start Year
1995
End Year
2018
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Investigators Contacts
  • Dr. David Goltzman
    McGill University
  • Dr. Nancy Kreiger
    University of Toronto
  • Claudie Berger
    McGill University

Design

Study design
Cohort
Follow Up

Participants were followed annually by postal questionnaire to obtain medication and fracture history. Details regarding reported fractures were obtained through a telephone interview. The data collection at Year 3 (participants aged 40-60 years), Year 5 (all participants), Year 10 (all participants) and Year 16 (women aged 60-75 years) follow-ups included an extensive interviewer-administered questionnaire and a clinical assessment (bone mineral density, X-rays, ultrasounds, height and weight measurements). Participants not selected to do a full interview at Year 3 and 16 follow-ups, received a short postal follow-up questionnaire on fractures. 

Supplementary Information

The Canadian Multicentre Osteoporosis Study (CaMos) is an ongoing population-based longitudinal study of community-dwelling adults (ages 25 years and older) recruited from 1995 to 1997. Between 2004 and 2006, a cohort of young women and men 16-24 years old was also recruited. Both cohorts have been drawn from a random population-based sample of non-institutionalized men and women living within 50 km of one of nine Canadian cities (St John’s, Halifax, Quebec City, Kingston, Toronto, Hamilton, Saskatoon, Calgary and Vancouver), referred to as centres, encompassing roughly 40% of the Canadian population. Households were randomly selected from residential phone numbers; participants were then selected from households by an age-stratified protocol. In the adult cohort (ages 25 years and older), this protocol weighted to older adults with two thirds women.

Marker Paper

Kreiger N, Tenenhouse A, Joseph L, Mackenzie T, Poliquin S, Brown JP, Prior JC, Rittmaster RS. (1999) The Canadian Multicentre Osteoporosis Study (CaMos): Background, rationale, methods. Can J Aging 18(3):376-87

Recruitment

Recruitment Target
  • Individuals

Number of Participants

Number of Participants
10,424
Number of Participants with Biological Samples
No Limit
Supplementary Information

6539 women and 2884 men aged 25 years and older; 527 young women and 474 young men aged 16-24 years.

Access

Availability of data and biosamples

Possible Access to Data
Possible Access to Biosamples
Other

All CaMos data are accessible to external researchers as long as they collaborate with one of the CaMos investigators.
Yes
No
Not applicable
Don't know

Timeline

Populations

Selection Criteria
Minimum age
25
Newborns
Twins
Countries
  • Canada
Territory

Living within 50 km of one of nine Canadian cities (St John’s, Halifax, Quebec City, Kingston, Toronto, Hamilton, Saskatoon, Calgary and Vancouver)

Ethnic Origin
Health Status
Other Criteria

Random selection of non-institutionalized adults

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample

Number of Participants

Number of Participants
9,423
Number of Participants with Biological Samples
No Limit
Supplementary Information about selection criteria

6539 women and 2884 men

Data Collection Events
# Name Description Start End
0 CaMos - Adult Cohort - Baseline

Baseline recruitment. Full interview with bone mineral density, X-ray, ultrasound, height, weight, blood and urine (Quebec only).

 1995-07 1997-09
1 CaMos - Adult Cohort - Year 1 Follow-up

Mailed questionnaire asking about fractures, hospital admissions, surgeries and medications (osteoporosis related).

 1996-08 1998-12
2 CaMos - Adult Cohort - Year 2 Follow-up

Mailed questionnaire asking about fractures, hospital admissions, surgeries and medications (osteoporosis related).

 1997-07 2000-02
3 CaMos - Adult Cohort - Year 3 Follow-up

Full interview with bone mineral density, height and weight for participants aged 40-60 years old.

 1998-07 2001-01
4 CaMos - Adult Cohort - Year 4 Follow-up

Mailed questionnaire asking about fractures, hospital admissions, surgeries and medications (osteoporosis related).

 1999-01 2001-12
5 CaMos - Adult Cohort - Year 5 Follow-up

Full interview with bone mineral density, X-ray, ultrasound, height, weight, blood & urine (Quebec, Calgary and Hamilton)

 2001-12 2004-01
6 CaMos - Adult Cohort - Year 6 Follow-up

Mailed questionnaire asking about fractures, hospital admissions, surgeries and medications (osteoporosis related).

 2002-08 2004-12
7 CaMos - Adult Cohort - Year 7 Follow-up

Mailed questionnaire asking about fractures, hospital admissions, surgeries and medications (osteoporosis related).

 2003-11 2006-02
8 CaMos - Adult Cohort - Year 8 Follow-up

Mailed questionnaire asking about fractures, hospital admissions, surgeries and medications (osteoporosis related).

 2004-10 2007-01
9 CaMos - Adult Cohort - Year 9 Follow-up

Mailed questionnaire asking about fractures, hospital admissions, surgeries and medications (osteoporosis related).

 2006-09 2009-01
10 CaMos - Adult Cohort - Year 10 Follow-up

Full interview with bone mineral density, X-ray, ultrasound, height, weight, blood & urine, DNA (all centers)

 2007-07 2010-01
11 CaMos - Adult Cohort - Year 11 Follow-up

Mailed questionnaire asking about fractures, hospital admissions, surgeries and medications (osteoporosis related).

 2008-09 2011-04
12 CaMos - Adult Cohort - Year 12 Follow-up

Mailed questionnaire asking about fractures, hospital admissions, surgeries and medications (osteoporosis related).

 2009-08 2011-11
13 CaMos - Adult Cohort - Year 13 Follow-up

Mailed questionnaire asking about fractures, hospital admissions, surgeries and medications (osteoporosis related).

 2011-03 2012-09
14 CaMos - Adult Cohort - Year 14 Follow-up

Mailed questionnaire asking about fractures, hospital admissions, surgeries and medications (osteoporosis related).

 2012-01 2013-12
15 CaMos - Adult Cohort - Year 15 Follow-up

Mailed questionnaire asking about fractures, hospital admissions, surgeries and medications (osteoporosis related).

 2013-01 2013-12
16 CaMos - Adult Cohort - Year 16 Follow-up

Full interview (in women 60-75/85) with bone mineral density, X-ray, ultrasound, height, weight, blood & urine (all centers), peripheral quantitative computed tomography (pQCT) (in some ...

 2014-01 2014-12
17 CaMos - Adult Cohort - Year 17 Follow-up

Mailed questionnaire asking about fractures, hospital admissions, surgeries and medications (osteoporosis related).

 2015-01 2015-12
18 CaMos - Adult Cohort - Year 18 Follow-up

Mailed questionnaire asking about fractures, hospital admissions, surgeries and medications (osteoporosis related).

 2016-01 2016-12
19 CaMos - Adult Cohort - Year 19 Follow-up

Mailed questionnaire asking about fractures, hospital admissions, surgeries and medications (osteoporosis related).

 2017-01 2017-12
20 CaMos - Adult Cohort - Year 20 Follow-up

Mailed questionnaire asking about fractures, hospital admissions, surgeries and medications (osteoporosis related).

 2018-01 2018-12
Selection Criteria
Minimum age
16
Maximum age
24
Newborns
Twins
Countries
  • Canada
Territory

Living within 50 km of one of nine Canadian cities (St John’s, Halifax, Quebec City, Kingston, Toronto, Hamilton, Saskatoon, Calgary and Vancouver)

Ethnic Origin
Health Status
Other Criteria

Random selection through phone directory

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample

Number of Participants

Number of Participants
1,001
Number of Participants with Biological Samples
No Limit
Supplementary Information about selection criteria

527 women and 474 men

Data Collection Events
# Name Description Start End
0 CaMos - Youth Cohort - Baseline

Baseline recruitment. Full interview with bone mineral density, ultrasound, height, weight, blood & urine (Calgary only)

 2004-07 2006-06
1 CaMos - Youth Cohort - Year 1 Follow-up

Short follow-up on fractures and medications, blood & urine (Quebec only)

 2005-09 2008-02
2 CaMos - Youth Cohort - Year 2 Follow-up

Full interview with bone mineral density, ultrasound, height, weight, blood & urine (6 centers), DNA (all)

 2006-08 2008-12

Classifications

Socio-demographic and economic characteristics
Lifestyle and behaviours
Birth, pregnancy and reproductive health history
Perception of health, quality of life, development and functional limitations
Diseases
Symptoms and signs
Medication and supplements
Non-pharmacological interventions
Health and community care services utilization
Death
Physical measures and assessments
Laboratory measures
Cognition, personality and psychological measures and assessments
Life events, life plans, beliefs and values
Preschool, school and work life
Social environment and relationships
Physical environment
Administrative information
Cognitive functioning
Personality
Psychological distress and emotions
Other psychological measures and assessments
Perception of health
Quality of life
Life course development
Functional limitations
Other perception of health, quality of life and functional limitation-related information

Socio-demographic and economic characteristics

Age/birthdate
Sex/gender
Family and household structure
Education
Residence
Birthplace
Ethnicity, race and religion
Language
Labour force and retirement

Lifestyle and behaviours

Tobacco
Alcohol
Nutrition
Breastfeeding
Physical activity
Sleep

Birth, pregnancy and reproductive health history

Puberty, menstruation, menopause and andropause
Contraception
Pregnancy, delivery and birth
Fertility and sexual health

Perception of health, quality of life, development and functional limitations

Quality of life
Functional limitations

Diseases

Neoplasms (C00-D48)
Endocrine, nutritional and metabolic diseases (E00-E90)
Mental and behavioural disorders (F00-F99)
Diseases of the nervous system (G00-G99)
Diseases of the circulatory system (I00-I99)
Diseases of the respiratory system (J00-J99)
Diseases of the digestive system (K00-K93)
Diseases of the musculoskeletal system and connective tissue (M00-M99)
Diseases of the genitourinary system (N00-N99)
Injury, poisoning and certain other consequences of external causes (S00-T98)
External causes of morbidity and mortality (V01-Y98)
Diseases without precise specification or falling into multiple categories

Medication and supplements

Medication and supplement intake
Posology and protocol of administration

Non-pharmacological interventions

Surgical interventions
Radiological interventions
Physical therapy interventions
Other and unspecified non-pharmacological interventions

Health and community care services utilization

Visits to health professionals
Hospitalizations
Community and social care
Other health and community care

Death

Cause of death

Physical measures and assessments

Anthropometry
Muscles, skeleton and mobility

Laboratory measures

Hematology
Biochemistry

Cognition, personality and psychological measures and assessments

Cognitive functioning

Social environment and relationships

Social support

Physical environment

Radiation exposure
Chemical exposure

Administrative information

Identifiers
Date and time-related information
Questionnaire and interview-related information
Physical and cognitive measure and biosample-related information
Data and sample collection center-related information
Other administrative information

Cognitive functioning

Mini-Mental State Examination

Quality of life

Health Utilities Index
Short-Form 36 Health Survey