Canadian Alliance for Healthy Hearts and Minds Cohort Study
Networks
-
Datasets
-
Variables
-
The objectives of the study are:
* To understand the role of socio-environmental and contextual factors (such as societal structure, activity, nutrition, social and tobacco environments, and access to health services) on cardiovascular (CV) risk factors, subclinical disease, and clinical CV events at the individual and population levels. This will include investigating the impact of contextual factors on geographic variation in CV disease (i.e. rural vs. urban, and east to west gradient), and their relative impact compared to individual level factors.
* To characterize the unique patterns of contextual factors as well as acculturation, cultural continuity, and migration experience as related to individual CV risk factors, health service utilization, and clinical outcomes among high risk ethnic groups including South Asians, Chinese, African origin from across Canada.
* To identify markers for early sub-clinical dysfunction in the brain, vessels, heart and abdomen using magnetic resonance imaging, and to investigate the associations with contextual and individual determinants of these markers, as well as to assess the predictive value of novel markers of sub-clinical dysfunction on the development of clinical CV events.
- Start Year
- 2013
- End Year
- 2021
- Funding
Visit CAHHM
| Investigators | Contacts |
|---|---|
|
|
Design
- Study design
- Cohort
- Follow Up
- All participants are assessed at enrollment.
- Supplementary Information
Marker Paper
Anand SS, Tu JV, Awadalla P et. al. Rationale, design, and methods for Canadian alliance for healthy hearts and minds cohort study – a Pan Canadian cohort study. BMC Public Health, 2016; 16:650.
PUBMED 27464510
Recruitment
- Recruitment Target
-
- Individuals
Number of Participants
- Number of Participants
- 8,258
- Number of Participants with Biological Samples
- 5,392
- Supplementary Information
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Timeline
CAHHM population
The population is composed of men and women aged 35-69 years, recruited from all participating cohorts of the Canadian Partnership for Tomorrow Project (CanPath), the Prospective Urban Rural Evaluation (PURE)-Canada cohort, and the Montreal Heart Institute (MHI) Biobank.
Selection Criteria
- Minimum age
-
35
- Maximum age
-
69
- Newborns
- Twins
- Countries
-
- Canada
- Territory
- Metropolitan Montreal and Quebec City, Greater Toronto Area, London, Hamilton, Ottawa, Metro Vancouver, Halifax and surrounding area, Calgary, Edmonton
- Ethnic Origin
-
- Health Status
-
- Other Criteria
- Exclusion criteria: * Participant is claustrophobic and/or is known to suffer from moderate to severe anxiety during MRI scans or similar procedures. * Participant is obese and/or exceeds equipment weight limit and/or circumference of the MRI portal at time of screening. * Participant has a metallic implant or another foreign body which is not compatible with Magnetic Resonance Imaging (MRI) (eg pacemakers, defibrillator, vascular clips, drug pumps, implant(s), or any other foreign bodies, extensive tattoo covering a large part of their chest or head). * Female participants that are or may be pregnant (confirmed or uncertain). * Received an MRI contrast agent within 72 h prior to the MRI scan. * Participants who live on Canadian aboriginal reserves.
Recruitment
- Sources of recruitment
-
- General population
- Participants from existing studies
- General Population
-
- Selected sample
- Participants from Existing Studies
-
- Canadian Partnership for Tomorrow Project
Prospective Urban Rural Evaluation (PURE)-Canada cohort
Montreal Heart Institute (MHI) Biobank
- Canadian Partnership for Tomorrow Project
Number of Participants
- Number of Participants
- 8,258
- Number of Participants with Biological Samples
- 4,333
Data Collection Event
Detailed information on individuals’ cancer and cardiovascular risk factors, health behaviors’ including dietary assessment, physical fitness and smoking, and social factors, was obtained using questionnaires. Information about community factors (Individual Perception), immigration, acculturation, CVD related health services was collected. The CPTP Core Baseline Health and Lifestyle Questionnaire was also used to collect information.
Measures of cognitive function using the Digit Symbol Substitution (DSS) test and the Montréal Cognitive Assessment (MoCA) were performed.
Physical measures including: height, weight, percent body fat using the Tanita BIA machine, waist circumference, hip circumference, resting heart rate, and blood pressure were assessed.
A standardized, comprehensive and cost-efficient multi-parametric MRI scan was attempted on all subjects. This includes the brain (ischemic white matter disease, covert strokes, cerebral atrophy and cerebral connectivity), the heart (morphology, volumes and mass, global and regional wall motion, pericardial fat, covert myocardial infarction, non-ischemic fibrosis, infiltration, perfusion and oxygenation), blood vessels (plaque volume) and the abdomen (visceral adipose tissue and liver fat).
Urine and blood samples were collected.
Participants’ cardiovascular and general health history, and vital status before enrollment was extracted from health care administrative databases through linkage of data.
- Start Date
-
2013-12
- End Date
-
2018-03
- Data sources
-
- Questionnaires
- Cognitive measures
- Physical measures
- Biosamples
- Administrative databases
- Data sources - Biosamples
-
- Blood
- Urine
- Data sources - Administrative databases
-
- Health databases
- Vital statistics databases
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
- Cognitive functioning
- Personality
- Psychological distress and emotions
- Other psychological measures and assessments
- Tobacco
- Alcohol
- Drugs
- Nutrition
- Breastfeeding
- Physical activity
- Sleep
- Sexual behaviours and orientation
- Technological devices
- Misbehaviour and criminality
- Other and unspecified lifestyle information
Socio-demographic and economic characteristics
Age/birthdate
Sex/gender
Marital/partner status
Residence
Birthplace
Citizenship and immigrant status
Ethnicity, race and religion
Language
Labour force and retirement
Income, possessions, and benefits
Lifestyle and behaviours
Tobacco
Alcohol
Nutrition
Physical activity
Transportation
Technological devices
Other and unspecified lifestyle information
Perception of health, quality of life, development and functional limitations
Perception of health
Quality of life
Other perception of health, quality of life and functional limitation-related information
Diseases
Certain infectious and parasitic diseases (A00-B99)
Endocrine, nutritional and metabolic diseases (E00-E90)
Diseases of the circulatory system (I00-I99)
Medication and supplements
Medication and supplement intake
Posology and protocol of administration
Non-pharmacological interventions
Surgical interventions
Radiological interventions
Educational and health promotion interventions
Laboratory diagnosis interventions
Other and unspecified non-pharmacological interventions
Health and community care services utilization
Visits to health professionals
Physical measures and assessments
Anthropometry
Circulation and respiration
Brain and nerves
Skin and subcutaneous tissue
Other physical measures and assessments
Laboratory measures
Hematology
Biochemistry
Cognition, personality and psychological measures and assessments
Cognitive functioning
Psychological distress and emotions
Other psychological measures and assessments
Life events, life plans, beliefs and values
Beliefs and values
Preschool, school and work life
Work life
Social environment and relationships
Social network
Social participation
Social support
Other social environment characteristics
Physical environment
Built environment/neighbourhood characteristics
Workplace characteristics
Administrative information
Identifiers
Date and time-related information
Questionnaire and interview-related information
Physical and cognitive measure and biosample-related information
Cognitive functioning
Montreal Cognitive Assessment
Nutrition
Food Frequency Questionnaire (different forms)