Adult Changes in Thought Study
The Adult Changes in Thought (ACT) is a prospective cohort study that focuses on dementia and Alzheimer's disease. It aims to create a "living laboratory" to study aging and dementia in older adults.The ACT study collects a variety of detailed information on demographics, risk factors, lifestyle, genetics, comorbidities, and outcomes and shares these data with interested investigators throughout the world.
- Start Year
- 1994
Visit ACT
| Investigators | Contacts |
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Design
- Study design
- Cohort
- Follow Up
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The participants are followed up with interviews every two years until diagnosis of dementia and/or Alzheimer's disease.
- Supplementary Information
Marker Paper
Kukull WA, Higdon R, Bowen JD, et al. Dementia and Alzheimer Disease Incidence: A Prospective Cohort Study. Arch Neurol. 2002;59(11):1737-1746. doi:10.1001/archneur.59.11.1737.
PUBMED 12433261
Recruitment
- Recruitment Target
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- Individuals
Number of Participants
- Number of Participants
- 4,960 (No Limit)
- Number of Participants with Biological Samples
- 4,960 (No Limit)
- Supplementary Information
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The ACT study is made up of three cohorts:
From 1994-1996 we enrolled a cohort of 2,581 people aged 65 years and older without dementia.
From 2000-2002, we enrolled an expansion cohort of 811 people using the same inclusion criteria.
From 2004-present, we began continuous enrollment using the same inclusion criteria to replace attrition from dementia, dropout, and death. We have a consistent cohort of ~2000 at risk for dementia. The total current enrollment of all three groups is 4,960.
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
Timeline
ACT population
The study population consists of 2581 men and women aged 65 or greater, in the Seattle area.
Selection Criteria
- Minimum age
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65
- Newborns
- Twins
- Countries
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- United States of America
- Territory
- Seattle
- Ethnic Origin
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- Health Status
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- Other Criteria
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Participants with an existing diagnosis of dementia or those who were in a skilled nursing community were excluded.
Recruitment
- Sources of recruitment
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- Specific population
- Specific Population
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- Members of an association
- Supplementary Information
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Random sample of members of the Group Health Cooperative of Puget Sound
Number of Participants
- Number of Participants
- 2,581
- Number of Participants with Biological Samples
- 2,581
- Supplementary Information about selection criteria
-
Recruitment 1: 2581 participants
Recruitment 2: 811 participants
Recruitment 3: Seeks to maintain population of approximately 2000 participants (ongoing)
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
ACT - Recruitment 1
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Data concerning demographic, medical history, function status, and potential epidemiological risk factors were collected. A blood sample was also obtained from consenting participants to ... |
1994 | 1996 |
| 1 |
ACT - Follow-up
|
Every two years, cohort members were rescreened to identify new cases of dementia. Cognitive Abilities Screening Instrument scores lower than 86 at follow-up triggered a full dementia ... |
1996 | 2014 |
| 2 |
ACT - Recruitment 2
|
A replacement cohort of 811 participants were enrolled between 2000 and 2002. Data concerning demographic, medical history, function status, and potential epidemiological risk ... |
2000 | 2002 |
| 3 |
ACT - Recruitment 3
|
Continuous enrollment of a replacement cohort from 2004 onward seeking to maintain a population of approximately 2000 participants. Data concerning demographic, medical ... |
2004 | 2014 |
Classifications
- Socio-demographic and economic characteristics
- Lifestyle and behaviours
- Birth, pregnancy and reproductive health history
- Perception of health, quality of life, development and functional limitations
- Diseases
- Symptoms and signs
- Medication and supplements
- Non-pharmacological interventions
- Health and community care services utilization
- Death
- Physical measures and assessments
- Laboratory measures
- Cognition, personality and psychological measures and assessments
- Life events, life plans, beliefs and values
- Preschool, school and work life
- Social environment and relationships
- Physical environment
- Administrative information
- Cognitive functioning
- Personality
- Psychological distress and emotions
- Other psychological measures and assessments
- Perception of health
- Quality of life
- Life course development
- Functional limitations
- Other perception of health, quality of life and functional limitation-related information
Socio-demographic and economic characteristics
Lifestyle and behaviours
Birth, pregnancy and reproductive health history
Perception of health, quality of life, development and functional limitations
Diseases
Medication and supplements
Non-pharmacological interventions
Health and community care services utilization
Death
Physical measures and assessments
Laboratory measures
Cognition, personality and psychological measures and assessments
Administrative information
Cognitive functioning
Psychological distress and emotions
Functional limitations