Collected Dataset / WHIMS_Estrogen_followup

The participants randomized in the estrogen hormone therapy group (conjugated equine estrogens 0.625 mg/day) were hysterectomized women, enrolled in the HRT trial of the WHI, who were aged 65 to 79 years at the time of WHIMS enrollment in 1996-1998.

The WHIMS measurement protocol had 4 ordered phases. Completion of phases 2 and 3 were done within 3 months of phase 1.

Phase 1: The Modified Mini-Mental Exam (3MS) was administered. Particpants scoring 72 or less proceeded to phases 2 and 3; after 16 months new cut-points of </= 80 for those with </= 8 years of education and </= 88 for those with >/= 9 years of education were implemented to increase the sensitivity of screener.

Phase 2: Portions of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological test battery (verbal fluency, naming, constructional praxis and praxis recall, word-list memory, recall and recognition), the Trail Making Test (visual, conceptual and visuomotor functions tests), the Structured Psychiatric Interview (depression, anxiety, panic and alcohol abuse disorders), the Geriatric Depression Scale-Short Form (nonsomatic depressive symptoms), the Acquired Cognitive and Behavior Changes (ACBC) (impairments of memory, language, personality, behavior, orientation, activities of daily living, social functioning and judgment problem-solving) and Friend/Family Member Interview (same as ACBC but for third parties) were performed.

Phase 3: A physician conducted a face-to-face semistructured neurologic evaluation that included: a review of past medical history, a clinical evaluation, a Mini-Mental State Exam, an evaluation for the presence of clinically significant depression, anxiety, panic or alcohol abuse or dependence and a checklist of clinical signs and symptoms used to distinguish progressive dementia from vascular dementia.

Phase 4: Each woman judged to have probable dementia in phase 3 underwent a series of laboratory tests to classify the type of dementia, which included blood analyses and noncontrast CT scan.

In addition to the 4 phases, various data were collected: medical history was updated on the first, third and sixth years, psychological questionnaires were readministered on the first, third and sixth years, information on physical activity was updated on the first and third years, and information regarding adherence to study medication was collected at each visit.