Maelstrom Research Staging

OBAS_I

Networks -

Variables -

Associated study OBAS Contingency Table

Population

OBAS - Study I

OBAS I

Selection Criteria

Minimum age

Newborns

Twins

Countries

United States of America

Territory

Portland, OR metro area.

Ethnic Origin

The participants are primarily Caucasian. One participant is Asian and another one is Native American.

Health Status

Free of most co-morbid illnesses

Other Criteria

Inclusion Criteria:

Principal language, English
Functionally independent
Has not sought evaluation for cognitive impairment
Willing and able to return for follow-up
Does not refuse to undergo post mortem examination
Score of < =12 on Instrumental Activities of Daily Living Scale (OARS)
Score of > =24 on Mini Mental State Exam
Score of <=10 on Cornell Depression Scale
Score of <= 11 on Geriatric Depression Scale
Score of 0 on Clinical Dementia Rating Scale
Gives informed consent
No exclusion criteria listed in below.

Exclusion criteria:

Medical Conditions

Diabetes mellitus
Hypertension (supine BP > 160/95)
Angina pectoris or myocardial infarction
Cardiac arrhythmia
Coronary bypass/carotid endarterectomy
Stroke or TIA
Parkinson disease
Chronic pulmonary disease
Chronic renal disease
Chronic immunosuppression
Vitamin deficiencies
Seizure disorder
Active cancer (< 5 years without recurrence)
Hypothyroidism)

Psychiatric Disorders

Chronic schizophrenia
Major affective disorders
Chronic anxiety or phobias

Vision and Hearing

Vision uncorrectable to 20/100 O.U.(near card)
Hearing loss (interferes with speech perception)

Other Conditions

Alcohol abuse / drug abuse
Significant head injury (>30 min unconscious)
Unexplained prolonged loss of consciousness
Use of medicines impairing cognitive function
Internal metal such as pacemakers, will be excluded from MR imaging

Recruitment

Sources of recruitment

General population

General Population

Volunteer enrolment

Participants from Existing Studies

Number of Participants

Number of Participants: 216
Number of Participants with Biological Samples: 209

More info

Data Collection Event

OBAS - Study I - Evaluation OBAS I

Rolling enrollment beginning March1989. Only 5 enrolled since 2003. Follow up is ongoing for those still alive and active in the study. Full protocol administered in person annually. Shorter subset of the main protocol administered at 6 months intervals between annual exams (administered in person until 2006, then changed telephone follow-up).

More info

Collected Dataset / OBAS_I

OBAS_I

Population

OBAS - Study I

Data Collection Event

OBAS - Study I - Evaluation OBAS I

Files

Variables Classifications