Maelstrom Research Staging | NARCRMS

NARCRMS_Enrollment

Networks -

Variables -

Associated study NARCRMS Contingency Table

Population

NARCRMS population

The population consists of individuals aged 18 to 65 years old who have relapsing or progressive multiple sclerosis, with a clear date of onset within 15 years.

Selection Criteria

Minimum age

Maximum age

Newborns

Twins

Countries

United States of America
Canada

Ethnic Origin

Health Status

Inclusion: Participants must have relapsing or progressive multiple sclerosis with clear date of onset within 15 years and evidence of clinical isolated syndrome typical of demyelination.
Exclusion: Concomitant confounding disorders like neuromyelitis optica and idiopathic isolated transverse myelitis, and/or known autoimmune disorders that can cause neurological disorders.

Other Criteria

Inclusion: EDSS up to 6.5

Recruitment

Sources of recruitment

Specific population

Specific Population

Clinic patients

Supplementary Information

Participants are recruited from approximately 25 to 27 enrollment sites chosen to geographically represent all regions across the U.S. and Canada. Recruitment sites include clinical sites and medical practices currently enrolled in the Consortium of Multiple Sclerosis Centers, as well as affiliated centers of the National Multiple Sclerosis Society.

Number of Participants

Number of Participants: 712
Number of Participants with Biological Samples

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Data Collection Event

NARCRMS - Enrollment

Information is collected by physicians, patient-reported and from medical records.

At enrollment, a disability is assessed through the score of Expanded Disability Status Scale (EDSS). Participants complete Case Report Forms (CRFs) which include the health-related productivity and health resource utilization questionnaires. Most information collected from patients focuses on disease challenges and impacts on daily life. Information such as demographics, medical history, illicit drug and tobacco history, history of infectious diseases, medication history and immunization history is also collected from questionnaires and clinical records.

Physicians administered standard of care neurological examinations, cognitive assessments and MRI scans.

Blood and urine samples were collected.

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Collected Dataset / NARCRMS_Enrollment

NARCRMS_Enrollment

Population

NARCRMS population

Data Collection Event

NARCRMS - Enrollment

Files

Variables Classifications