Collected Dataset / h70_h70cohort6_Followup_1

The population consisted of a representative sample of 70-year-old men and women born in 1944 and living in Göteborg in 2014.

Participants are 75 years old at this time point. Information on urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history, and onset and course of dementia information is collected from close informant. Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities, and life events. Medication, self-rated health, and quality of life (ICECAP-O Quality of Life Scale) related information are collected. The psychiatric examinations were performed by psychiatrists and included ratings of psychiatric symptoms and signs with the Comprehensive Psychopathological Rating Scale, Mini-D, Montreal Cognitive Assessment, Alzheimer's Disease Assessment Scale, Clinical Dementia Rating instrument, Gottfries-Bråne-Steen Scale), perceptual speed test (PSIF), Mini Mental State Examination, other signs common in dementia, personality inventories (Cesarec Marke Personality Schedule, Eysenck Personality Questionnaire) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior. Somatic examinations include assessment of medical conditions (e.g., hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer), the Cumulative Illness Rating Scale for Geriatrics, anthropometric measurements, blood pressure, ECG, brain scans (CT and MRI), lung function, measures of atherosclerosis, body composition (DEXA), Romberg balance test, grip strengths and walking capacity. Blood samples are taken and include e.g., hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum, and plasma are frozen for future analyses. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and, post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV, or DSM-5. Somatic disorders are classified according to established criteria using information from examinations, close informants, and hospital register data.