Maelstrom Research Staging | DOORWAY

DOORWAY_followup

Networks -

Variables -

Associated study DOORWAY Contingency Table

Population

Children with acute asthma

Children aged 1 to 17 years visiting one of five pediatric emergency departments namely CHU Ste-Justine, Montreal Children's Hospital, CHU de Laval, Children's Hospital of Eastern Ontario, Children’s Hospital of London Health Sciences Centre with a moderate or severe asthma exacerbation (PRAM score ≥4).

Selection Criteria

Minimum age

Maximum age

Newborns

Twins

Countries

Canada

Territory

Montreal, Quebec, Ottawa and London

Ethnic Origin

Health Status

Moderate to severe asthma exacerbation

Other Criteria

Participants were eligible if they: (1) were aged 1–17 years; (2) had asthma, defined as: (i) prior diagnosis of asthma made by a physician; (ii) prior documented episode of acute cough, wheezing and/or dyspnoea with significant response to inhaled β2-agonists or to oral corticosteroids; (iii) in a child aged <2 years, three or more episodes of cough, wheezing and/or dyspnoea, including the index visit or (iv) previous lung function tests showing significant reversibility postbronchodilation (≥12% FEV1 or ≥25% Rrs at 4–8 Hz) or a positive provocation test (PC20 ≤8 mg/mL or provocation dose (to increase Rrs by 50% or more (PD50) ≤8 mg/mL), in keeping with the American Thoracic Society and European Respiratory Society criteria; (3) presented with an acute episode of cough, wheezing and/or dyspnoea; (4) had moderate-to-severe airway obstruction, defined as a PRAM score >3 at baseline; (5) had a good understanding of English or French and (6) were accompanied by parents or legal guardians.

Patients were excluded if they presented: (1) with another chronic respiratory condition (such as bronchopulmonary dysplasia or cystic fibrosis); (2) with a reasonable suspicion of bronchiolitis or foreign body aspiration; (3) a history of hypersensitivity to salbutamol, ipratropium bromide or oral prednisolone; (4) a relative or absolute contraindication to receiving oral corticosteroids such as recent exposure to varicella or live vaccine in a susceptible child or (5) with confirmed or suspected pregnancy status.

Recruitment

Sources of recruitment

Specific population

Specific Population

Other specific population :
Children visiting emergency department with an asthma exacerbation.

Participants from Existing Studies

Number of Participants

Number of Participants

975

Number of Participants with Biological Samples

968

Supplementary Information about selection criteria

From 975 enrolled patients:

Patients provided DNA samples: 906 samples

Patients provided Cotinine samples: 930 samples

Patients provided nasopharyngeal samples: 968 samples

Patients provided sputum samples: 11 samples

More info

Data Collection Event

10-day follow up period

10-day follow up period: Patient functional status measured daily on the ‘Asthma flare-up Diary for young children©’, use of rescue and controller medications documented on a diary, parental functional status measured at the end of the exacerbation on the ‘Effects of a child’s asthma flare-up on the parents©’ questionnaire, 10-day follow-up parental report summarizing return visits to ED and hospital admissions, adverse events, serious adverse events, and review of ED log and phone follow up by the research assistant.

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Collected Dataset / DOORWAY_followup

DOORWAY_followup

Population

Children with acute asthma

Data Collection Event

10-day follow up period

Files

Variables Classifications